Abstract:
:The connection between Helicobacter pylori (Hp) infection and eye diseases has been increasingly reported in the literature and in active research. The implication of this bacterium in chronic eye diseases, such as blepharitis, glaucoma, central serous chorioretinopathy and others, has been hypothesized. Although the mechanisms by which this association occurs are currently unknown, this review describes shared pathogenetic mechanisms in an attempt to identify a lowest common denominator between eye diseases and Hp infection. The aim of this review is to assess whether different studies could be compared and to establish whether or not Hp infection and Eye diseases share common pathogenetic aspects. In particular, it has been focused on oxidative damage as a possible link between these pathologies. Text word search in Medline from 1998 to July 2014. 152 studies were included in our review. Were taken into considerations only studies that related eye diseases more frequent and/or known. Likely oxidative stress plays a key role. All of the diseases studied seem to follow a common pattern that implicates a cellular response correlated with a sublethal dose of oxidative stress. These alterations seem to be shared by both Hp infections and ocular diseases and include the following: decline in mitochondrial function, increases in the rate of reactive oxygen species production, accumulation of mitochondrial DNA mutations, increases in the levels of oxidative damage to DNA, proteins and lipids, and decreases in the capacity to degrade oxidatively damaged proteins and other macromolecules. This cascade of events appears to repeat itself in different diseases, regardless of the identity of the affected tissue. The trabecular meshwork, conjunctiva, and retina can each show how oxidative stress may acts as a common disease effector as the Helicobacter infection spreads, supported by the increased oxidative damage and other inflammation.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Saccà SC,Vagge A,Pulliero A,Izzotti Adoi
10.1097/MD.0000000000000216subject
Has Abstractpub_date
2014-12-01 00:00:00pages
e216issue
28eissn
0025-7974issn
1536-5964pii
00005792-201412030-00010journal_volume
93pub_type
杂志文章,评审相关文献
MEDICINE文献大全abstract::Olfactory outcomes as well as oronasal postoperative complications of transsphenoidal pituitary surgery have not been well studied. The objective of this study was to investigate nasal symptoms including olfactory function as well as quality of life following transsphenoidal pituitary surgery. The study is designed as...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000465
更新日期:2015-01-01 00:00:00
abstract::Ultrasonographic microcalcification is highly related to papillary thyroid cancer (PTC) and pathologic psammoma body is a poor prognostic factor. However, it is little known about whether the microcalcifications seen on ultrasonography are consistent with the pathologic psammoma bodies. We evaluated the relationship b...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012675
更新日期:2018-10-01 00:00:00
abstract::Within the overall National Health Insurance (NHI) budget in Taiwan, there has been a remarkable increase in expenditure for cancer patients. This study was designed to explore whether hematological malignancy is associated with higher end-of-life (EOL) medical expenditure in their last 6 months of life.We used data f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001036
更新日期:2015-07-01 00:00:00
abstract::Although the association between malignancy and thromboembolic disease is well established, the relative risk of developing initial and recurrent deep vein thrombosis (DVT) or pulmonary embolism (PE) among patients with malignancy versus those without malignancy has not been clearly defined. The Medicare Provider Anal...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199909000-00001
更新日期:1999-09-01 00:00:00
abstract::This study aimed to evaluate the psychological distress and associated risk factors for distress among patients with gastric epithelial neoplasm undergoing endoscopic submucosal dissection (ESD).A total of 91 patients treated with ESD for gastric epithelial neoplasm between May 2015 and June 2016 were prospectively en...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013912
更新日期:2018-12-01 00:00:00
abstract:RATIONALE:Crohn disease includes 3 phenotypes, inflammatory, stricturing, and penetrating. In cases where corticosteroids and immunosuppressive agents are not suitable treatment options, enteral nutrition (EN) can be used to reduce disease severity and enhance barrier defense with fewer potential adverse effects. PATI...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016750
更新日期:2019-08-01 00:00:00
abstract:RATIONALE:Castleman disease (CD) is a rare lymphoproliferative disease with a poorly understood etiology. The occurrence of CD in the abdominal cavity is very rare, especially in the retroperitoneal peripancreatic region. PATIENT CONCERNS:A 33-year-old woman was referred to our department on March 1, 2018 for a detail...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019515
更新日期:2020-03-01 00:00:00
abstract:RATIONALE:Pancreaticopleural and pancreaticomediastinal fistulas are rare complications of pancreatitis. They are often misdiagnosed and there are no strict guidelines of treatment. In this study, we present a brief report of a combined pancreaticopleural and pancreaticomediastinal fistula extending to the cervical reg...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014233
更新日期:2019-02-01 00:00:00
abstract::Integrative oncology is being increasingly adopted in mainstream cancer care to strengthen anticancer effects and to control cancer-related symptoms.The objective of this study is to identify the characteristics of patients with lung cancer treated at an integrative cancer center in Korea and to determine the effects ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016048
更新日期:2019-06-01 00:00:00
abstract::Population aging has rapidly advanced throughout the world and the elderly accounting for out-of-hospital cardiac arrest (OHCA) has increased yearly.We identified all adults who experienced an out-of-hospital cardiac arrest in the All-Japan Utstein Registry of the Fire and Disaster Management Agency, a prospective, po...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002049
更新日期:2015-12-01 00:00:00
abstract::Acute myocardial infarction (AMI) is recognized as being a life-threatening event. Both microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH) have been recognized as poor prognostic factors in myocardial infarct (MI) since they adversely affect left ventricular remodeling. MVO refers to small vessels ch...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011617
更新日期:2018-07-01 00:00:00
abstract::In this study, balance performance, agility, eye-hand coordination, and sports performance were compared between amateur badminton players and active controls.Thirty young adult badminton players and 33 active controls participated in the study. Static single-leg standing balance (with eyes closed) was measured using ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014134
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Dry eye disease is a common eye disease mainly manifests with eye fatigue, foreign body sensation, dry and astringent eyes and other symptoms. Growing evidence shows that qiming granule may have beneficial effects on the clinical treatment of dry eye disease. However, no systematic review and meta-analysis c...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017121
更新日期:2019-09-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is known to be one of the leading causes of end-stage renal disease (ESRD). The aim of this study was to estimate the incidence rate of ESRD and the risk for progression to ESRD in SLE patients compared to the general population.A total of 21,253 SLE patients were extracted from the ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016420
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:Based on existing literature, the juxtaglomerular cell tumor (JGCT) is a rare renal tumor, typically present with hypertension and hypokalemia. Nonfunctioning JGCT, without hypertension or hypokalemia, is extremely rare. PATIENT CONCERNS:Herein, we report a case of nonfunctioning JGCT mimicking renal cell...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022057
更新日期:2020-09-04 00:00:00
abstract:RATIONALE:Solitary fibrous tumor is a rare mesenchymal tumor. This case report describes the diagnosis and treatment of this tumor. PATIENT CONCERNS:A 31-year-old patient presented with epileptic seizure and headache 1 day prior to the visit and showed transient right limb hemiplegia for 6 hours that was resolved afte...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023504
更新日期:2020-12-11 00:00:00
abstract:BACKGROUND:Chronic low back pain (CLBP) is a clinically common and recurrent disease. However, many trials have shown that auriculotherapy (AT) can effectively treat CLBP. There are currently no systematic reviews of this therapy. The plan aims to evaluate the effectiveness and safety of this treatment in patients with...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019722
更新日期:2020-04-01 00:00:00
abstract::Nephrogenic diabetes insipidus (NDI) is a condition resulting from the kidney's impaired response to circulating antidiuretic hormone (ADH), leading to polydipsia and polyuria. Urinary tract dilatation caused by NDI is a rare situation. Here, we report a case of congenital NDI presented with bilateral hydronephrosis.A...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003464
更新日期:2016-05-01 00:00:00
abstract::Augmentation of implants with polymethylmethacrylate (PMMA) bone cement in osteoporotic fractures is a promising approach to increase implant purchase. Side effects of PMMA for the metaphyseal bone, particularly for the adjacent subchondral bone plate and joint cartilage, have not yet been studied. The following exper...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000414
更新日期:2015-01-01 00:00:00
abstract::Informed consent has now become common in medical practice. However, a gap still exists between doctors and patients in the understanding of clinical conditions. We designed medical comics about "subarachnoid hemorrhage" and "intracerebral hemorrhage" to help doctors obtain informed consent intuitively, quickly, and c...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001077
更新日期:2015-07-01 00:00:00
abstract::The effect of the afternoon napping duration on the risk of depression has not been well established, particularly with regard to sex and age differences. The present study examines the association between afternoon napping duration and depression stratified by sex and age among Chinese adults aged 45 years or older.T...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022686
更新日期:2020-10-23 00:00:00
abstract::Allogeneic blood transfusions (ABTs) are common in patients with cancer. The present study investigated the safety of a restrictive ABT strategy in patients with extremity sarcomas.Patients who underwent operations for extremity bone sarcomas between May 2008 and November 2018 were retrospectively reviewed. Clinical o...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018482
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:To investigate the radiation dose and image quality for iterative reconstruction combined with the CARE kV technique in chest computed tomography (CT) scanning for physical examination. METHODS:A total of 130 patients who underwent chest CT scanning were randomly chosen and the quality reference value was s...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000006175
更新日期:2017-03-01 00:00:00
abstract::This study aims to analyze the characteristics of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for cerebral alveolar echinococcosis (CAE).Twenty-five CAE patients underwent F-FDG PET/CT, and the diagnosis was confirmed by clinical and surgical pathology. The F-FDG PET/CT results...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011801
更新日期:2018-09-01 00:00:00
abstract::To describe and analyze the clinical features and prognosis of patients with anti-Hu associated paraneoplastic neurological syndromes (PNS).The symptoms, MRI findings, cerebrospinal fluid (CSF) changes, electroencephalogram (EEG) characteristics and prognoses of 9 well-diagnosed anti-Hu associated PNS patients were an...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010649
更新日期:2018-05-01 00:00:00
abstract:RATIONALE:Thyroglobulin (Tg) is an accurate indicator of clinical outcome after total thyroidectomy in patients with differentiated thyroid carcinoma. Usually, Tg levels agree with whole body scan. However, in some patient, discordant results were found, often because of Tg immunoassay interference. Several reports ind...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014178
更新日期:2019-02-01 00:00:00
abstract:RATIONALE:Adrenocortical carcinoma is a rare aggressive type of cancer whose prognosis is poor, particularly for metastatic entities. Metastatic adrenocortical carcinoma in the spine is a rare disease with no standard curative managements yet. The objective of this study is to report a very rare case of spinal metastas...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000018259
更新日期:2019-12-01 00:00:00
abstract::Carbamazepine (CBZ) is a widely used antiepileptic drug with large interindividual variability in serum concentrations. Previous studies found that CYP3A5*3 (rs776746), UGT2B7*2 (802C>T), and UGT2B7*3 (211G>T) variants could change the enzymes' activity, which may influence drug concentrations. Our study aims to inves...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011662
更新日期:2018-07-01 00:00:00
abstract::We present 11 patients with immunotactoid glomerulopathy, a new syndrome characterized clinically by proteinuria (11/11), microscopic hematuria (9/11) and hypertension (9/11). The patients consisted of six females and five males, aged 25 to 59 years (mean, 44.6). Proteinuria was the presenting feature and the reason f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-198507000-00004
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:To investigate the relationship between intracerebral hemorrhage hematoma expansion with low serum calcium level. METHODS:We will search the following electronic bibliographic databases: MEDLINE, Embase, PubMed, The Cochrane Library, and Web of Science. All sources have to be searched from the earliest date...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018844
更新日期:2020-01-01 00:00:00