Abstract:
:Susceptometry-based oximetry (SBO) and T2-relaxation-under-spin-tagging (TRUST) are two promising methods for quantifying the cerebral metabolic rate of oxygen (CMRO2), a critical parameter of brain function. We present a combined method, interleaved TRUST (iTRUST), which achieves rapid, simultaneous quantification of both susceptometry- and T2-based CMRO2 via insertion of a flow-encoded, dual-echo gradient-recalled echo (OxFlow) module within the T1 recovery portion of the TRUST sequence. In addition to allowing direct comparison between SBO- and TRUST-derived venous oxygen saturation (Yv) values, iTRUST substantially improves TRUST temporal resolution for CMRO2 quantification and obviates the need for a separate blood flow measurement following TRUST acquisition. iTRUST was compared directly to TRUST and OxFlow alone in three resting subjects at baseline, exhibiting close agreement with the separate techniques and comparable precision. These baseline data as well as simulation results support the use of two instead of the traditional four T2 preparation times for T2 fitting, allowing simultaneous quantification of susceptometry- and T2-based Yv (and CMRO2) with three- and six-second temporal resolution, respectively. In 10 young healthy subjects, iTRUST was applied during a 5% CO2 gas mixture-breathing paradigm. T2-based Yv values were lower at baseline relative to susceptometry (62.3 ± 3.1 vs. 66.7 ± 5.1 %HbO2, P<0.05), but increased more in response to hypercapnia. As a result, T2-based CMRO2 decreased from 140.4 ± 9.7 to 120.0 ± 9.5 μMol/100g/min, a significant -14.6 ± 3.6% response (P < 0.0001), whereas susceptometry-based CMRO2 changed insignificantly from 123.4 ± 18.7 to 127.9 ± 25.7, a 3.3 ± 9.7% response (P = 0.31). These differing results are in accord with previous studies applying the parent OxFlow or TRUST sequences individually, thus supporting the reliability of iTRUST but also strongly suggesting that a systematic bias exists between the susceptometry- and T2-based Yv quantification techniques.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Rodgers ZB,Englund EK,Langham MC,Magland JF,Wehrli FWdoi
10.1016/j.neuroimage.2014.10.061subject
Has Abstractpub_date
2015-02-01 00:00:00pages
441-50eissn
1053-8119issn
1095-9572pii
S1053-8119(14)00900-8journal_volume
106pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::MR diffusion tensor imaging (DTI) can measure and visualize organization of white matter fibre tracts in vivo. DTI is a relatively new imaging technique, and new tools developed for quantifying fibre tracts require evaluation. The purpose of this study was to compare the reliability of a novel clustering approach with...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.12.028
更新日期:2009-04-01 00:00:00
abstract::It has been well established over the last two decades that walking is not merely an automatic, motoric activity; it also utilizes executive function circuits, which play an increasingly important role in walking for older people and those with mobility and cognitive deficits. Dual-task walking, such as walking while ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.01.045
更新日期:2019-04-01 00:00:00
abstract::Extracellular β-amyloid (Aβ) plaque deposits and inflammatory immune activation are thought to alter various aspects of tissue microstructure, such as extracellular free water, fractional anisotropy and diffusivity, as well as the density and geometric arrangement of axonal processes. Quantifying these microstructural...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116138
更新日期:2019-11-15 00:00:00
abstract::Conway (Conway, M.A., 1992. A structural model of autobiographical memory. In: Conway, M.A., Spinnler, H., Wagenaar, W.A. (Eds.), Theoretical Perspectives on Autobiological Memory. Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 167-194) proposed that two types of autobiographical memories (AMs) exist with...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.08.007
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:The primary purpose of this investigation was to assess the neural correlates of implicit cueing during an inhibitory task in schizophrenia when performance accuracy was matched with healthy comparison subjects. METHODS:We compared 17 individuals with chronic schizophrenia (SZ; medicated, 13.9 average years...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.04.189
更新日期:2006-08-15 00:00:00
abstract::Characterizing demyelination/degeneration of spinal pathways in traumatic spinal cord injured (SCI) patients is crucial for assessing the prognosis of functional rehabilitation. Novel techniques based on diffusion-weighted (DW) magnetic resonance imaging (MRI) and magnetization transfer (MT) imaging provide sensitive ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.11.089
更新日期:2011-04-01 00:00:00
abstract::The ability to execute several actions in a specific temporal order to achieve an overarching goal, a process often termed action cascading or multi-component behavior, is essential for everyday life requirements. We are only at the beginning to understand the neurobiological mechanisms important for these cognitive p...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.10.007
更新日期:2017-02-01 00:00:00
abstract::Adolescence is increasingly viewed as a sensitive period in the development of substance use disorders (SUDs). Neurodevelopmental 'dual-risk' theories suggest adolescent vulnerability to problematic substance use is driven by an overactive reward drive mediated by the striatum, and poor cognitive control mediated by t...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116476
更新日期:2020-04-01 00:00:00
abstract::Nuclear magnetic resonance (NMR) relaxation in the rotating frame is sensitive to molecular dynamics on the time scale of water molecules interacting with macromolecules or supramolecular complexes, such as proteins, myelin and cell membranes. Hence, longitudinal (T1ρ) and transverse (T2ρ) relaxation in the rotating f...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.12.007
更新日期:2014-04-01 00:00:00
abstract::In humans and monkeys the mirror neuron system transforms seen actions into our inner representation of these actions. Here we asked if this system responds also if we see an industrial robot perform similar actions. We localised the motor areas involved in the execution of hand actions, presented the same subjects bl...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.02.003
更新日期:2007-05-01 00:00:00
abstract::Positive affect elicited in a mother toward her newborn infant may be one of the most powerful and evolutionarily preserved forms of positive affect in the emotional landscape of human behavior. This study examined the neurobiology of this form of positive emotion and in so doing, sought to overcome the difficulty of ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2003.10.005
更新日期:2004-02-01 00:00:00
abstract::Divergent thinking tests have been used extensively in neuroscientific studies of creativity. However, output from tests of divergent thinking can be scored in different ways, and those scores can influence assessments of divergent thinking performance and its relationship with brain activation. Here we sought to inve...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117325
更新日期:2020-12-01 00:00:00
abstract::Large amounts of multimodal neuroimaging data are acquired every year worldwide. In order to extract high-dimensional information for computational neuroscience applications standardized data fusion and efficient reduction into integrative data structures are required. Such self-consistent multimodal data sets can be ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.03.055
更新日期:2015-08-15 00:00:00
abstract::Reliable quantification of white matter hyperintensities of presumed vascular origin (WMHs) is increasingly needed, given the presence of these MRI findings in patients with several neurological and vascular disorders, as well as in elderly healthy subjects. We present BIANCA (Brain Intensity AbNormality Classificatio...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.07.018
更新日期:2016-11-01 00:00:00
abstract::Aberrant patterns of brain functional connectivity in the default mode network (DMN) have been observed across different classes of substance use disorder (SUD) and are associated with craving and relapse. In addicted individuals resting functional connectivity (RSFC) of the anterior DMN, which participates in attribu...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2019.06.036
更新日期:2019-10-15 00:00:00
abstract:UNLABELLED:The brainstem contains various important monoaminergic neuronal centers, including the raphe nuclei which contain serotonergic neurons. The raphe nuclei, however, are not easily identifiable and located by conventional neuroimaging. METHODS:Fluorodeoxyglucose positron emission tomography (PET) and magnetic ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.09.036
更新日期:2012-01-16 00:00:00
abstract::Anesthesia-induced changes in functional connectivity and cerebral blow flow (CBF) in large-scale brain networks have emerged as key markers of reduced consciousness. However, studies of functional connectivity disagree on which large-scale networks are altered or preserved during anesthesia, making it difficult to fi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.12.080
更新日期:2017-03-01 00:00:00
abstract::Functional positron emission tomography (fPET) is a neuroimaging method involving continuous infusion of 18-F-fluorodeoxyglucose (FDG) radiotracer during the course of a PET examination. Compared with the conventional bolus administration of FDG in a static PET scan, which provides an average glucose uptake into the b...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116720
更新日期:2020-06-01 00:00:00
abstract::Emotional experience in healthy men has been shown to rely on a brain network including subcortical as well as cortical areas in a complex interaction, which may be substantially influenced by many internal personal and external factors such as individuality, gender, stimulus material and task instructions. The diverg...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2005.01.014
更新日期:2005-05-15 00:00:00
abstract::Activation of the sympathetic nervous system (SNS) is essential in adapting to environmental stressors and in maintaining homeostasis. This reaction can also turn into maladaptation, associated with a wide spectrum of stress-related diseases. Up to now, the cortical mechanisms of sympathetic activation in acute mental...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.12.004
更新日期:2010-04-01 00:00:00
abstract::Methylphenidate (MPH) is a stimulant drug that amplifies dopamineric and noradrenergic signaling in the brain, which is believed to underlie its cognition enhancing effects. However, the neurobiological effects by which MPH improves cognition are still poorly understood. Here, functional magnetic resonance imaging (fM...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.10.060
更新日期:2011-02-14 00:00:00
abstract::Statistical parametric mapping (SPM) is currently the most widely used method for analysis of functional activation images. This paper reports a quantitative evaluation of the sensitivity and accuracy of SPM, using a realistic simulator of PET image formation, which accounted for the main physical processes involved i...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1006/nimg.2000.0655
更新日期:2001-01-01 00:00:00
abstract::The ability to regulate temptation and manage appetitive cravings is an important aspect of healthy adolescent development, but the neural systems underlying this process are understudied. In the present study, 60 healthy females evenly distributed from 10 to 23years of age used reappraisal to regulate the desire to c...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.12.037
更新日期:2015-03-01 00:00:00
abstract::Blood-oxygen-level-dependent (BOLD) resting-state functional MRI (rsfMRI) has emerged as a valuable tool to map complex brain-wide functional networks, predict cognitive performance and identify biomarkers for neurological diseases. However, interpreting these findings poses challenges, as the neural basis of rsfMRI c...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.06.063
更新日期:2019-11-01 00:00:00
abstract::The identification of brain systems contributing to different aspects of visuospatial attention is of both clinical and theoretical interest. Cued target detection tasks provide a simple means to dissociate attentional subcomponents, such as alerting, orienting or reorienting of attention. Event-related functional mag...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.neuroimage.2003.08.044
更新日期:2004-01-01 00:00:00
abstract::Brain oscillations are supposedly crucial for normal cognitive functioning and alterations are associated with cognitive dysfunctions. To demonstrate their causal role on behavior, entrainment approaches in particular aim at driving endogenous oscillations via rhythmic stimulation. Within this context, transcranial el...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.06.026
更新日期:2015-09-01 00:00:00
abstract::The intention of our study was to compare functional magnetic resonance imaging (fMRI) with positron emission tomography (PET). We used the same force-related motor paradigm for both techniques, which allows for quantification of stimulus intensity. Regional cerebral blood flow (rCBF) was determined with PET in six ma...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1996.0071
更新日期:1996-12-01 00:00:00
abstract::Functional MRI (fMRI) studies of jaw motion, speech, and swallowing disorders have been hampered by motion artifacts. Tissue motion perturbs the static magnetic field, creating geometric distortions in echo-planar images that lead to many false positives in activation maps. These problems have restricted blood oxygena...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2005.08.063
更新日期:2006-02-15 00:00:00
abstract::The chronology of the component processes subserving working memory (WM) and hemodynamic response lags has hindered the use of fMRI for exploring neural substrates of WM. In the present study, however, participants completed full trials that involved encoding two or six letters, maintaining the memory set over a delay...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.08.054
更新日期:2010-01-15 00:00:00
abstract::Magnetization transfer ratio (MTR), diffusion tensor imaging (DTI) parameters and T(1) relaxometry values were used to create parametric maps characterizing the tissue microstructure of the neonatal brain in infants born very premature (24-32 gestational weeks) and scanned at preterm and term equivalent age. Group-wis...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.08.086
更新日期:2013-01-01 00:00:00