Abstract:
:The mechanisms involved in the recognition of microbial pathogens and activation of the immune system have been extensively studied. However, the mechanisms involved in the recovery phase of an infection are incompletely characterized at both the cellular and physiological levels. Here, we establish a Caenorhabditis elegans-Salmonella enterica model of acute infection and antibiotic treatment for studying biological changes during the resolution phase of an infection. Using whole genome expression profiles of acutely infected animals, we found that genes that are markers of innate immunity are down-regulated upon recovery, while genes involved in xenobiotic detoxification, redox regulation, and cellular homeostasis are up-regulated. In silico analyses demonstrated that genes altered during recovery from infection were transcriptionally regulated by conserved transcription factors, including GATA/ELT-2, FOXO/DAF-16, and Nrf/SKN-1. Finally, we found that recovery from an acute bacterial infection is dependent on ELT-2 activity.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Head B,Aballay Adoi
10.1371/journal.pgen.1004609subject
Has Abstractpub_date
2014-10-23 00:00:00pages
e1004609issue
10eissn
1553-7390issn
1553-7404pii
PGENETICS-D-14-00123journal_volume
10pub_type
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