Abstract:
OBJECTIVE:Attention deficit hyperactivity disorder (ADHD) is the most common psychiatric childhood disorder. The most commonly used drugs in the treatment of ADHD are methylphenidate (MPH) and atomoxetine (ATX); the former of the two is prescribed in USA more than it is in Western Europe. Some of the most important safety concerns about ADHD drug treatment are sudden cardiac death and suicidal behavior. In this study, we present a series of cases of Italian children who had presented suicidal ideation during ADHD pharmacological therapy with ATX. RESEARCH DESIGN AND METHODS:Data were obtained from the ADHD Italian Register. The data assessed the use of MPH and ATX, which had been prescribed to patients who were aged < 18 years and diagnosed with ADHD. All patients enrolled in the ADHD Italian Register treated with ATX or MPH who experienced suicidal thoughts or thoughts of self-harming were considered and assessed. RESULTS:We describe the clinical cases of seven Italian children (enrolled in the ADHD Italian Register) treated with ATX and affected by suicidal ideation, self-harming or other similar symptoms. Our results highlighted that all seven patients developed suicidal ideation or intentional self-harming during pharmaceutical treatment with ATX and, particularly, after the dose increase of the drug. CONCLUSION:There is a need to improve our knowledge about the efficacy and safety of ATX, MPH and other drugs used in the treatment of ADHD both in children and adults during the post-marketing experience.
journal_name
Expert Opin Drug Safjournal_title
Expert opinion on drug safetyauthors
Capuano A,Scavone C,Rafaniello C,Arcieri R,Rossi F,Panei Pdoi
10.1517/14740338.2014.941804subject
Has Abstractpub_date
2014-09-01 00:00:00pages
S69-78eissn
1474-0338issn
1744-764Xjournal_volume
13 Suppl 1pub_type
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
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