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Enzymatic synthesis of polybrominated dioxins from the marine environment.

Abstract：

:Polyhalogenated dibenzo-p-dioxins are arguably among the most toxic molecules known to man. In addition to anthropogenic sources, marine invertebrates also harbor polybrominated dibenzo-p-dioxins of as yet unknown biogenic origin. Here, we report that the bmp gene locus in marine bacteria, a recently characterized source of polybrominated diphenyl ethers, can also synthesize dibenzo-p-dioxins by employing different phenolic initiator molecules. Our findings also diversify the structural classes of diphenyl ethers accessed by the bmp biosynthetic pathway. This report lays the biochemical foundation of a likely biogenetic origin of dibenzo-p-dioxins present in the marine metabolome and greatly expands the toxicity potential of marine derived polyhaloganated natural products.

journal_name

ACS Chem Biol

journal_title

ACS chemical biology

authors

Agarwal V,Moore BS

doi

10.1021/cb5004338

subject

Has Abstract

pub_date

2014-09-19 00:00:00

pages

1980-4

issue

9

eissn

1554-8929

issn

1554-8937

journal_volume

9

pub_type

信件

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