Abstract：
BACKGROUND:This preliminary ex vivo study aimed to clarify the pathophysiologic mechanisms of fat tissue depletion by subcutaneous drug application. Therefore, the lipolytic effects of phosphatidylcholine plus deoxycholate (Lipostabil) (L) and of deoxycholate (DC) alone were compared with those of sodium chloride (NaCl) and hydrogen peroxide (H2O2) as control agents. The study enrolled 10 patients receiving abdominoplasty. The treatment periods for each sample and solution were 1, 3, 5, and 7 h. The samples were analyzed morphologically using hematoxylin-eosin (H&E) staining and also immunohistochemically using Caspase 3 and tumor necrosis factor (TNF)-alpha. Morphologic changes were seen best after 5 h of application time. Except for NaCl, all the samples in the H&E staining showed marked damage of adipocyte cell membranes, with the greatest disruption of normal cell architecture after hydrogen peroxide (H2O2) application. Immunohistochemistry using TNF-alpha showed positive results for the deoxycholate and Lipostabil samples and highly positive results for the H2O2 sample. Data from this study indicate that Lipostabil and deoxycholate induce pathways of cell necrosis involving TNF-alpha. These short-term experiments indicate that Lipostabil affects fat tissue in the way of a chemical-toxic destruction rather than via a physiologically induced, programmed cell death.
journal_name
Aesthetic Plast Surgjournal_title
Aesthetic plastic surgeryauthors
Hübner NF,Horch RE,Polykandriotis E,Rau TT,Dragu Adoi
10.1007/s00266-014-0371-xsubject
Has Abstractpub_date
2014-10-01 00:00:00pages
976-84issue
5eissn
0364-216Xissn
1432-5241journal_volume
38pub_type
杂志文章abstract：BACKGROUND:The demand for decorative tattoos is steadily growing worldwide, and in the US it is estimated that up to 24% of adults has one or more tattoos. Subsequently, the number of tattoo-related complications is increasing. Among these, lymphoproliferative disorders play a minor but important role. The aim of this ...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章,评审
doi：10.1007/s00266-014-0287-5
更新日期：2014-04-01 00:00:00
abstract：:The practice of injecting phosphatidylcholine/sodium deoxycholate compounds into subcutaneous fat is growing rapidly. As with any new procedure, a standard of practice should be developed so that practitioners maintain patient safety as the primary goal. Efficacy and predictability of outcome are another priority. As ...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章,评审
doi：10.1007/s00266-008-9188-9
更新日期：2008-11-01 00:00:00
abstract：:The independent effect of the contraction of various facial mimetic muscles on the nasolabial fold was defined through study of cadaver dissections. The four major lip elevator muscles were identified and the effect of traction of these muscles on the nasolabial fold was studied. This study identified the levator alae...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/BF00450609
更新日期：1992-04-01 00:00:00
abstract：:Since 2017, there have been an increasing number of reported cases regarding breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in the literature. Although significant attention was dispensed for this relevant issue, there is no consensus on what the trigger points for disease development are. BIA-ALC...
journal_title：Aesthetic plastic surgery
pub_type： 评论,信件
doi：10.1007/s00266-019-01602-3
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:The objective of this article was to assist cosmetic-plastic surgeons in selecting aesthetic cosmetic gynecologic-plastic surgical interventions. METHODS:Target methodological analyses of pertinent evidence-based scientific papers and anecdotal information linked to surgical techniques for cosmetic-plastic ...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章,评审
doi：10.1007/s00266-012-0031-y
更新日期：2013-04-01 00:00:00
abstract：:Facial linear scars with concave and erythematous appearance sometimes occur after long observation even if adequate conservative treatments have been applied. Because the regenerated epithelium is thin, those scars are seen as red or pink, and are sometimes accompanied with postinflammatory hyperpigmentation. For the...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-003-0124-8
更新日期：2003-05-01 00:00:00
abstract：:After augmentation mammaplasty, either subglandular or submuscular, the most typical complication to occur is capsule formation or its advanced form, capsular contracture. Even the less severe capsule formation can cause a feeling of discomfort because the breast starts to be fixed to the rear chest wall, thus resulti...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-005-0082-4
更新日期：2006-05-01 00:00:00
abstract：:The aging female with excess arm fat and poor skin tone frequently refuses a brachioplasty scar due to permanent detectability. Traditional deep liposuction localized to the posterolateral aspect of the arm frequently leaves sagging, wrinkled skin. Circumferential para-Axillary Superficial Tumescent (CAST) liposuction...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s002669900144
更新日期：1997-11-01 00:00:00
abstract：:A study was undertaken to determine the physical properties and microscopic structure of the superficial musculoaponeurotic system (SMAS) tissue. Forty virginal specimens and eight reoperated specimens were examined. The following findings were discovered. 1) Microscopic appearance shows the SMAS to consist of collage...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s002669900113
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Cosmetic surgery is no longer just for females. More men are opting for cosmetic procedures, with marked increases seen in both minimally invasive and surgical options over the last decade. Compared to females, relatively little work has specifically focused on factors predicting males' attitudes toward cosm...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-017-0882-3
更新日期：2017-12-01 00:00:00
abstract：:Although posterior closure of male pattern baldness is usually accomplished in two procedures when using extensive scalp-lifting, there is the occasional patient who will require three operations because of very poor scalp laxity. A newly developed horseshoe-shaped tissue expander was designed for these patients so th...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/BF02273884
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND:Abdominoplasties carried out in patients previously underwent gastroplasty present high rates of complications, including increased bleeding in the intra- and postoperative periods. METHODS:This study evaluated bleeding, coagulation parameters (coagulogram, dosage of fibrinogen, FII, FV, FVII, FVIII, FIX, F...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-012-9976-0
更新日期：2012-12-01 00:00:00
abstract：:Based on prior experience with implant exposure, an aggressive regimen to eradicate periprosthetic infections has proven successful in delayed gram-positive and gram-negative bacterial infections and in atypical microbacterial infections. The objective of the "salvage" procedure is to retain a prosthesis, to maintain ...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/BF01570333
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Lipoinjection is a promising treatment but has some problems, such as unpredictability and a low rate of graft survival due to partial necrosis. METHODS:To overcome the problems with lipoinjection, the authors developed a novel strategy known as cellassisted lipotransfer (CAL). In CAL, autologous adiposeder...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-020-01819-7
更新日期：2020-08-01 00:00:00
abstract：:Seventy-seven cases of delayed or inadequately treated zygoma fractures, treated between 1977 and 1999 in the Maxillofacial Surgery Division of the La Sapienza University in Rome, are presented. The functional and aesthetic problems caused by this pathology are analyzed. The results achieved resolve some of the variou...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-002-1484-1
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:The treatment of a tuberous breast deformity has changed over the years, with a large variety of procedures described. However, maintaining a long-lasting breast contour is an ongoing challenge. The aim of this study was to evaluate the long-term results of tuberous breast corrections, focusing on the incide...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-017-0902-3
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Rhinoplasty is known to increase attractiveness; however, the influence of observer age and gender are largely undetermined. METHODS:This retrospective cross-sectional study included 20 women who underwent cosmetic rhinoplasty between January 1st, 2012, and December 31st, 2019. A total of 4 surveys were con...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-020-02030-4
更新日期：2020-10-29 00:00:00
abstract：BACKGROUND:In patients with a thin soft tissue breast envelope, lower pole implant palpability is a postoperative sequela that concerns patients. Anatomically, the lower aspect of the breast near the inframammary fold lacks sufficient soft tissue to cover the breast implant after augmentation. METHODS:A transareolar i...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-018-1215-x
更新日期：2018-12-01 00:00:00
abstract：:A modification of the standard periareolar incision is described. It provides better access for augmentation mammoplasty and gynecomastia, as well as allowing for correction of asymmetry in the size and siting of the nipple-areola complex. Finally, it achieves a very slight tightening of the skin envelope in cases of ...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/BF01571118
更新日期：1983-01-01 00:00:00
abstract：:Gender-reassignment therapy, especially for reshaping of the forehead, can be an effective treatment to improve self-esteem. Contouring of the cranial vault, especially of the forehead, still is a rarely performed surgical procedure for gender reassignment. In addition to surgical bone remodeling, several materials ha...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-011-9731-y
更新日期：2011-12-01 00:00:00
abstract：:An innovative bury-and-knot suturing method for firm fixation of a graft through a small skin incision is described and two clinical cases presented. ...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/BF00455146
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The question of whether expander inflation/deflation status has any bearing on surgical complications in the setting of adjuvant radiation (XRT) has not been addressed. The objective of this study is to investigate whether the inflation/deflation status of the expander at the time of XRT is associated with c...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-017-0864-5
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Dermal fillers are increasingly popular for facial rejuvenation and enhancement, including effacement of nasolabial folds (NLFs) and marionette lines and lip augmentation. This study aimed to evaluate casual observer perception of physical and interpersonal traits of subjects who receive filler treatment. M...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-020-01888-8
更新日期：2020-07-21 00:00:00
abstract：INTRODUCTION:Infantile haemangioma is the most common childhood tumour. These tumours can cause significant functional and cosmetic problems. While there are many treatment modalities, propranolol is increasingly being recognised as the first-line treatment of problematic haemangiomas. This study investigates the use o...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-015-0557-x
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Botulinum toxin A (BTX-A) is a medical product that is used widely in cosmetics, and concern over the safety profile has increased among injectors and patients. OBJECTIVE:The purpose was to enhance the statistical effect size using a meta-analysis to detect the incidence rate of adverse events (AEs) in the ...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00266-016-0682-1
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Plastic surgeons are always concerned about integrity of facial vascularization in smokers and elderly candidates for face-lifting. Using Doppler ultrasound, this study aimed to evaluate influence of chronic smoking and aging on facial transverse and infraorbital artery blood flow. METHODS:For this study, 4...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-006-0171-z
更新日期：2007-09-01 00:00:00
abstract：:Maxillary and mandibular anterior segmental osteotomies (ASO) are ways to correct disharmony in the lip (contour, lip seal, and profile) and occasional dentoalveolar malocclusion. We performed 23 maxillary setback ASO, three maxillary advancement ASO, 21 mandibular setback ASO, and six mandibular advancement ASO in 28...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/BF02274734
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:Facial and cranial asymmetry is common in bilateral vertebrates, particularly human beings. Through years of injecting fillers and performing face-lift operation on patients, we began to observe that more fillers were required on the right side to reach symmetry and also more loose skin and soft tissue was o...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-019-01526-y
更新日期：2020-02-01 00:00:00
abstract：:In this retrospective study, a brief description of the folds located lateral to the lips' commissurae and their anatomy is followed by a method to improve or eliminate them with local procedures. These folds, referred to as paralabial folds, can be treated by either limited resection or liposuction. The method descri...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-003-3003-4
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:The hammock technique combines inferior pedicle mammaplasty with retropectoral and inferior suspensions to prevent displacement of breast tissue toward the inferior mammarian pole. This study aimed to assess the long-lasting internal suspension with the author's mammary reduction technique. METHODS:From 198...
journal_title：Aesthetic plastic surgery
pub_type： 杂志文章
doi：10.1007/s00266-006-0188-3
更新日期：2007-05-01 00:00:00
