Abstract：
OBJECTIVES:Mild therapeutic hypothermia (MTH) is being used to improve neurological outcome and survival in patients successfully resuscitated after cardiac arrest. The impact on coagulation may be difficult to assess since most coagulation parameters are measured at 37°C and not at actual body core temperature. Therefore we investigated the effects of MTH both at body core (target) temperature of 32°C and at 37°C. METHODS:Patients admitted at the ICU after cardiac arrest treated with MTH. Baseline blood samples, measured at 37°C were taken directly at arrival. The second and third samples were drawn within 1h and 24h after reaching target temperature and were measured at 32°C and 37°C. A final sample was drawn when the patient returned to normotemperature (measured at 37°C). Clotting time (CT) and maximum clotting formation (MCF) were measured with thromboelastometry. RESULTS:Upon reaching target temperature (32°C) Extem and Intem CT were increased compared to baseline with 57s (49-75) to 65s (59-72) and 165s (144-183) to 193s (167-212) respectively (median with IQR; P<0.05), with a further significant increase after 24h of hypothermia with 68s (57-80) and 221s (196-266). Samples analyzed at 32°C showed a significant longer CT of 12s in Extem and 33s in Intem compared to 37°C. MCF was not affected by MTH or adjustment of temperature. CONCLUSION:The mild effect of MTH on coagulation parameters remains unidentified when measured at 37°C. Although measurements at 32°C differ from those at 37°C, this does not appear to be of clinical relevance as all values were still within the reference range.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Brinkman AC,Ten Tusscher BL,de Waard MC,de Man FR,Girbes AR,Beishuizen Adoi
10.1016/j.resuscitation.2014.06.009subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1359-63issue
10eissn
0300-9572issn
1873-1570pii
S0300-9572(14)00598-Xjournal_volume
85pub_type
杂志文章相关文献
RESUSCITATION文献大全abstract：AIM:Crude survival has increased following an out-of-hospital cardiac arrest (OHCA). We aimed to study sex-related differences in patient characteristics and survival during a 10-year study period. METHODS:Patients≥12 years old with OHCA of a presumed cardiac cause, and in whom resuscitation was attempted, were identi...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.06.008
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVES:The timing of and interval between events in prehospital care is important for system design, patient outcome, and prehospital research. Since these data can guide treatment recommendations, it is imperative that time-based prehospital documentation is accurate and precise, especially for time-sensitive cond...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.05.002
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Animal studies and pathophysiological considerations suggest that therapeutic hypothermia after cardiopulmonary resuscitation is the more effective the earlier it is induced. Therefore this study is sought to examine whether pharmacological facilitated hypothermia by administration of 5'-adenosine monophosph...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.05.030
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:Triage after resuscitation from cardiac arrest is hindered by reliable early estimation of brain injury. We evaluated the performance of a triage model based on early bispectral index (BIS) findings and cardiac risk classes. METHODS:Retrospective evaluation of serial patients resuscitated from cardiac arr...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.04.016
更新日期：2014-08-01 00:00:00
abstract：AIM:Stomach inflation during cardiopulmonary resuscitation (CPR) is frequent, but the effect on haemodynamic and pulmonary function is unclear. The purpose of this study was to evaluate the effect of clinically realistic stomach inflation on haemodynamic and pulmonary function during CPR in a porcine model. METHODS:Af...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2008.12.001
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Intra-aortic balloon pump (IABP) counterpulsation in cardiogenic shock (CS) is suggested as bridging therapy to definite emergency revascularization, heart transplantation and acute valvular repair. Data concerning the use of IABP counterpulsation in an emergency department (ED) are rare. PATIENTS AND METHO...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(02)00036-9
更新日期：2002-06-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to examine the prognostic value of continuous amplitude-integrated electroencephalogram (aEEG) applied immediately after return of spontaneous circulation (ROSC) in therapeutic hypothermia (TH)-treated cardiac arrest patients. METHODS:From September 2010 to August 2011, we pr...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.09.031
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Recent studies have demonstrated higher-quality chest compressions (CCs) following a 60 s ultra-brief video (UBV) on compression-only CPR (CO-CPR). However, the effectiveness of UBVs as a CPR-teaching tool for lay bystanders in public venues remains unknown. OBJECTIVE:Determine whether an UBV is effective i...
journal_title：Resuscitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.resuscitation.2014.06.013
更新日期：2014-09-01 00:00:00
abstract：:Serum lactic acidosis is characterized by a pH less than 7.25 and lactate greater than 5 mEq. Although sodium bicarbonate (NaHCO3) is standard treatment for this condition, clinical and experimental studies suggest that high doses of NaHCO3 may be ineffectual or even detrimental to brain, cardiovascular, and respirato...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(88)90015-9
更新日期：1988-01-01 00:00:00
abstract：AIM:To describe the change in the occurrence of ventricular fibrillation as initially observed arrhythmia among patients suffering from out-of-hospital cardiac arrest in Sweden. PATIENTS:All patients included in the Swedish cardiac arrest registry between 1991 until 2001. The registry covers 85% of the population in S...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2003.11.003
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Recent cardio pulmonary resuscitation (CPR) guidelines changed the compression:ventilation ratio in 30:2. OBJECTIVE:To compare the quality of chest compressions and exhaustion using the ratio 30:2 versus 15:2. METHODS:A prospective, randomised crossover design was used. Subjects were recruited from the H.-...
journal_title：Resuscitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.resuscitation.2006.12.004
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVES:Conflicting data exists regarding the association between sex and mortality in adults with in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA). We therefore conducted a meta-analysis to investigate the association between sex and mortality in adults with IHCA and OHCA. METHODS:We systematically sea...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/j.resuscitation.2020.07.031
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:this study determines the effect of prior hypothermia on the cardiovascular responses to norepinephrine (NE) after rewarming. METHODS:the experiment was a 2x2 controlled design with four groups of feline animals. The two variables were the presence or absence of previous cooling, and the use or non-use of NE...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(00)00185-4
更新日期：2000-08-01 00:00:00
abstract：AIM:To assess the experience, knowledge and attitudes of local primary health-care doctors towards resuscitation in out-of-hospital cardiac arrest. METHODS:We conducted a survey of general practitioners (GPs) working in both private and public sectors. The survey consisted of 29 questions and was self-administered. R...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2004.11.021
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To assess the possibility of heart rate variability (HRV) measures as predictors of 24-h mortality in successfully resuscitated patients with out-of-hospital cardiac arrest (OHCA). METHODS:This prospective cohort study was conducted at a 40-bed emergency department (ED) of a university-affiliated medical cen...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2009.06.020
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Dispatcher-assisted cardiopulmonary resuscitation (DACPR) could improve the survival rate of out-of-hospital cardiac arrest (OHCA). However, the efficiency of DACPR varies. Our study compared the effectiveness of DACPR instructed via landline calls, mobile calls, and landline calls transferred to mobiles. M...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2019.11.008
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The epidemiology and outcome after out-of-hospital cardiac arrest (OHCA) varies across Europe. Following on from EuReCa ONE, the aim of this study was to further explore the incidence of and outcomes from OHCA in Europe and to improve understanding of the role of the bystander. METHODS:This prospective, mul...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2019.12.042
更新日期：2020-03-01 00:00:00
abstract：:This study evaluated the effects of sodium-hydrogen exchanger (NHE1) inhibition on enhancing fluid resuscitation outcomes in traumatic hemorrhagic shock, and examined the mechanisms related to NHE1 inhibitor-induced protection and recovery from hemorrhagic shock. Traumatic hemorrhage was modeled in anesthetized pigs b...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2011.11.025
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:The ability of T-piece resuscitators to deliver consistent peak inspiratory pressure (PIP) and positive end expiratory pressure (PEEP) during real and simulated neonatal resuscitation has been well described. The Neopuff (Fisher & Paykel Healthcare, Auckland, New Zealand) has been the device used for nearl...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2011.02.017
更新日期：2011-06-01 00:00:00
abstract：:Semiautomated external defibrillators are widely used by prehospital emergency personnel. Some of the devices have a rhythm display and some show only text commands on the screen. To evaluate the effects on cardiopulmonary resuscitation (CPR) performance of seeing the rhythm during resuscitation, 60 fire-fighter stude...
journal_title：Resuscitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-9572(02)00208-3
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:Survival after out-of-hospital cardiac arrest (OOHCA) in an urban environment is directly proportional to speed of defibrillation and effective bystander cardiopulmonary resuscitation (CPR). We hypothesized that the hospital discharge rate from rural OOHCA was affected by the same factors. METHODS:We studied...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(02)00273-3
更新日期：2003-01-01 00:00:00
abstract：AIM:The aim of this study was to calculate the incidence of out-of-hospital cardiac arrest (OHCA) in primary health care in Greece and assess general practitioners' (GPs) willingness towards the use of automatic external defibrillator (AED). METHODS:We conducted a survey in GPs working in both private and public secto...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2011.04.010
更新日期：2011-09-01 00:00:00
abstract：:The completeness of brain ischemia with a multi-arterial clamping method in dogs was examined using EEG, evoked potentials (EPs) and vessel staining with Evans blue. EEG was monitored by bipolar parietal lead. EPs stimulating electrodes were inserted into the first thoracic (T1) epidural space and recording electrodes...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(91)90031-s
更新日期：1991-12-01 00:00:00
abstract：:A 2-month-old female infant presented with septic shock, refractory to high doses of catecholamines. Continuous infusion of terlipressin at a rate of 10 mcg/kgh produced a significant increase in the mean arterial pressure that was evident within half and hour, so allowing a reduction in the rate of catecholamine infu...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2005.06.016
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Analysis of in-hospital mortality after serious adverse events (SAE's) in our hospital showed the need for more frequent observation in medical and surgical wards. We hypothesized that the incidence of SAE's could be decreased by introducing a standard nurse observation protocol. AIM:To investigate the effe...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.06.017
更新日期：2013-02-01 00:00:00
abstract：UNLABELLED:The aim of this study was to characterize gene expression following hemorrhagic shock and resuscitation with emphasis on the differences between various resuscitation strategies. METHODS:Male Sprague Dawley rats (n = 25; 5/group) were subjected to a three stage hemorrhage and resuscitated as follows: (1) sh...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(02)00095-3
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:It has been shown that a computer-based audible feedback system can improve acquisition and retention of basic life support (BLS) skills. This system is being developed to work in association with an automated external defibrillator (AED). AIM:To determine if such a feedback system is likely to improve the ...
journal_title：Resuscitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-9572(02)00400-8
更新日期：2003-04-01 00:00:00
abstract：AIM OF STUDY:High-quality CPR is associated with improved outcomes from out-of-hospital cardiac arrest (OHCA). The purpose of this investigation was to compare the quality of CPR provided at the prehospital scene, during ambulance transport, and during the early minutes in the emergency department (ED). METHODS:A pros...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.07.042
更新日期：2013-05-01 00:00:00
abstract：AIMS OF THE STUDY:Neurological impairment after resuscitated cardiac arrest (CA) remains a significant unmet medical need. Brain ischemia associated with CA and subsequent reperfusion is evident as two fundamentally different types of damage on neuropathological examination: frank necrosis (involving all cell types) an...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2019.04.012
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and ...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.resuscitation.2018.12.002
更新日期：2019-01-01 00:00:00
