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Association between sex and mortality in adults with in-hospital and out-of-hospital cardiac arrest: A systematic review and meta-analysis.

Abstract：

OBJECTIVES:Conflicting data exists regarding the association between sex and mortality in adults with in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA). We therefore conducted a meta-analysis to investigate the association between sex and mortality in adults with IHCA and OHCA. METHODS:We systematically searched MEDLINE and Cochrane databases to identify studies reporting sex-specific mortality in adults following IHCA or OHCA from inception to April 2020. Data were pooled using random-effects models. The primary outcome of interest was in-hospital (or 30-day) all-cause mortality. RESULTS:We included 21 observational studies with a total of 1,029,978 adult patients - 622,085 men and 407,893 women. Seven studies included patients only with IHCA and 14 studies included patients only with OHCA. Female sex was associated with significantly higher mortality following OHCA [odds ratio (OR) 1.56, 95% confidence interval (CI) 1.32-1.84, p < 0.001) and a trend toward higher mortality following IHCA (OR 1.10, 95%CI 1.00-1.20, p = 0.052). CONCLUSIONS:In adults with cardiac arrest, female sex was associated with significantly higher mortality following OHCA and a trend toward higher mortality following IHCA.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Parikh PB,Hassan L,Qadeer A,Patel JK

doi

10.1016/j.resuscitation.2020.07.031

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

119-124

eissn

0300-9572

issn

1873-1570

pii

S0300-9572(20)30308-7

journal_volume

155

pub_type

杂志文章,评审

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