Abstract:
:Occurrence of arsenic in the aquatic environment of West Bengal (India), Bangladesh and other countries are of immediate environmental concern. In the present study, zebrafish (Danio rerio) was used as a model to investigate oxidative stress related enzyme activities and expression of antioxidant genes in the brain to 50µg/L arsenic trioxide for 90 days. In treated fish, generation of reactive oxygen species (ROS), malondialdehyde (MDA) and conjugated diene (CD) showed a triphasic response attaining a peak at the end of the exposure. In addition, a gradual increase in GSH level was noted until 60 days and at 90 days, a sudden fall was recorded which heightened arsenic toxicity. However, GSH level does not correlate well with the glutathione reductase (GR) activity. Generation of ROS in zebrafish brain due to As2O3 exposure was further evidenced by significant alteration of glutathione peroxidase (GPx) and catalase (CAT) activity, which converts H2O2 to water and helps in detoxication. Moreover, enhanced mRNA level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in As2O3 exposed zebrafish indicates a protective role of Nrf2. kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2, inversely correlates with the mRNA expression of Nrf2. As2O3 induced toxicity was also validated by the alteration in NRF2 and NRF2 dependent expression of proteins such as heme oxygenase1 (HO1) and NAD(P)H dehydrogenase quinone1 (NQO1). The mRNA expression of glutathione peroxidase (Gpx1), catalase (Cat), manganese superoxide dismutase (Mn-Sod), copper/zinc superoxide dismutase (Cu/Zn Sod) and cytochrome c oxidase1 (Cox1) were also up regulated. The expression of uncoupling protein 2 (Ucp2), an important mitochondrial enzyme was also subdued in arsenic exposed zebrafish. The oxidative stress induced by arsenic also cause reduced mRNA expression of B-cell lymphoma 2 (Bcl2) present in the inner mitochondrial membrane and thereby indicating onset of apoptosis in treated fish. It is concluded that even a low dose of arsenic trioxide is toxic enough to induce significant oxidative stress in zebrafish brain.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Sarkar S,Mukherjee S,Chattopadhyay A,Bhattacharya Sdoi
10.1016/j.ecoenv.2014.05.012subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1-8eissn
0147-6513issn
1090-2414pii
S0147-6513(14)00221-8journal_volume
107pub_type
杂志文章abstract::Examination of plants with strong Cu tolerance and an understanding of their Cu-tolerance mechanisms are of considerable significance for the remediation of Cu-contaminated soil. Although spinach may be a plant with strong Cu tolerance, the threshold of Cu tolerance in this plant and its physiological response mechani...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2019.01.016
更新日期:2019-04-30 00:00:00
abstract::The presented study investigates the use of passive sampling, i.e. solid phase microextraction with polydimethylsiloxane fibers (PDMS-SPME), to assess the bioavailability of fiver neutral organic chemicals (phenanthrene, pyrene, lindane, p,p'-DDT, and PCB 153) spiked to natural and artificial soils after different agi...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2013.11.011
更新日期:2014-02-01 00:00:00
abstract::Urban emissions are a major contributor to atmospheric Hg budgets. Continuous measurements of total gaseous mercury (TGM) and particulate-bound mercury (PHg) in PM2.5 were conducted from October 2015 to July 2016 in a metropolis, Jinan, in eastern China. Average TGM and PHg concentrations were 4.91 ± 3.66 ng m-3 and 4...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110541
更新日期:2020-06-15 00:00:00
abstract::The uptake of cadmium by cultured vegetative clones of the aquatic fern Marsilea minuta was studied in a static experimental bioassay system as functions of dose and period of exposure. The pathomorphological manifestations of Cd toxicity, as studied by transmission electron microscope, indicated damage to chloroplast...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/0147-6513(91)90019-l
更新日期:1991-04-01 00:00:00
abstract::Triclosan (TCS) is an antimicrobial and is an aquatic contaminant. Little is known on aquatic toxicity of TCS. Rotifers are common members of freshwater zooplankton. In this study, Brachionus calyciflorus was chosen as a test organism to assess the acute and complete life cycle toxicity of TCS in this study. The acute...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2015.12.043
更新日期:2016-05-01 00:00:00
abstract::The ultrastructure of Nilaparvata lugens brain cells was damaged by treatment at different fipronil concentrations. The cell showed swollen mitochondria and vacuolization, but no mitochondrial cristae. Rough endoplasmic reticulum (RER) fragmentation and degranulation were seen. The dilatation of endoplasmic reticulum ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2011.03.011
更新日期:2011-07-01 00:00:00
abstract::European eel (Anguilla anguilla) were exposed to sublethal fenitrothion concentrations in a continuous flow-through system for 4 days. Brain acetylcholinesterase (AChE) activity was evaluated after 2, 8, 12, 24, 32, 48, 56, 72, and 96 h pesticide exposure. Results indicated that AChE activity in eel brains decreased a...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1006/eesa.1997.1579
更新日期:1997-12-01 00:00:00
abstract::Degradation and enantioselective bioaccumulation of diniconazole in earthworms (Eiseniafetida) in artificial soil was investigated using liquid chromatography-tandem mass spectrometry (LC-MS/MS) method under laboratory condition. Three exposure concentrations (1 mg/kg, 10 mg/kg and 25 mg/kg) of diniconazole in soil (d...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2013.10.017
更新日期:2014-01-01 00:00:00
abstract::Exposure to Bisphenol A (BPA) has been reported to dysregulate endocrine pathways in a wide array of vertebrate species. The effects of BPA on invertebrate species are less well understood. We tested the effects of BPA on growth and development in Drosophila as these processes are governed by well-studied endocrine pa...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2013.12.008
更新日期:2014-03-01 00:00:00
abstract::We investigated the effect of clay content on the bioavailability of copper to the earthworm Eisenia fetida, in the laboratory for 28 days using OECD artificial soil adjusted to 5%, 20% and 40% clay. Mortality, growth, cocoon production and internal copper concentrations were assessed in worms, and total, DTPA and CaC...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2009.03.017
更新日期:2010-03-01 00:00:00
abstract::The effects of chlorpyrifos, an organophosphorus insecticide, were examined on the activity of the nervous system enzyme acetylcholinesterase (AChE) in the threeridge mussel Amblema plicata in a 24-day laboratory test. Thirty-six mussels in each of seven treatments (18 mussels per duplicate) were exposed to chlorpyrif...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1006/eesa.2000.2036
更新日期:2001-05-01 00:00:00
abstract::The aim of this study was to evaluate antioxidative responses in roots, stem and leaves of four alfalfa cultivars to different concentrations of zinc (Zn) (0, 300, 600 and 900 μM) for 23 days. Among the four cultivars, Aohan displayed the highest Zn concentrations in tissues and the largest Zn amount in aerial parts. ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2014.04.044
更新日期:2015-04-01 00:00:00
abstract::The 24-h toxicity of 20 substituted chlorophenols upon Lebistes reticulatus has been determined. The biological results have been tentatively connected with several of the following six parameters: logarithm of the octanol-water partition coefficient (log P); index of molecular connectivity (1 chi v); molecular refrac...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/0147-6513(84)90026-5
更新日期:1984-06-01 00:00:00
abstract::Glutathione-dependent defense against xenobiotic toxicity is a multifaceted phenomenon that has been well characterized in mammals. This study undertakes a comparison of two benthic fish species, the channel catfish and brown bullhead, in terms of characteristics of the glutathione system. The channel catfish, a speci...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1006/eesa.1994.1036
更新日期:1994-06-01 00:00:00
abstract::This research assesses the effects of nitrite pulses and post-exposure periods after nitrite exposures on the survival of the freshwater amphipod Eulimnogammarus toletanus. A toxicity bioassay was performed using three different nitrite concentrations (0.5, 5.0 and 10.0 mg/L NO(2)-N), four pulse exposures (1, 8, 24 an...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2009.06.008
更新日期:2009-10-01 00:00:00
abstract::In this study, we examined the chronic waterborne and dietary exposure of silver (Ag) and cadmium (Cd) to the abalone Haliotis diversicolor using various endpoints such as growth and feeding rates, metal body burden, subcellular distribution, and metallothionein (MT) concentration over a period of 7 weeks of exposure....
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2010.05.018
更新日期:2010-09-01 00:00:00
abstract::During the past three decades, North Atlantic populations of dogwhelks have been severely reduced in numbers, due to imposex and female sterility caused by TBT. We examined the relationship between the known history of female sterility and the present genetic diversity (measured by five allozyme-loci) and phenotypic v...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2005.11.006
更新日期:2006-06-01 00:00:00
abstract::Heavy metals are well known as environmental pollutants with hazardous impacts on human and animal health because of their wide industrial usage. In the present study, the role of Spirulina platensis in reversing the oxidative stress-mediated brain injury elicited by lead acetate exposure was evaluated. In order to ac...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.03.068
更新日期:2018-08-15 00:00:00
abstract::Chelating agents have been considered as an important phytoremediation strategy to enhance heavy metal extraction from contaminated soil. A pot experiment was conducted to explore the effects of low molecular weight organic acids (LMWOAs) on the phytoremediation efficiency of copper (Cu) by castor bean, and soil enzym...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110983
更新日期:2020-10-15 00:00:00
abstract::In this study pillar[5]arene (P5) and a quinoline-functionalized pillar[5]arene (P5-6Q) which is used for detecting radioactive element, gas adsorption and toxic ions were synthesized. These materials were characterized by Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared (FTIR), elemental analysis, melting...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110328
更新日期:2020-04-01 00:00:00
abstract::In 2010, the Deepwater Horizon oil spill released 134 million gallons of crude oil into the Gulf of Mexico making it the largest oil spill in US history. The three month oil spill left tens of thousands of birds dead; however, the fate of tens of thousands of other migratory birds that were affected but did not immedi...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2017.05.028
更新日期:2017-12-01 00:00:00
abstract::Disinfection byproducts (DBPs) are generated by disinfectants reacting with organic matters. Previous studies have focused on DBPs in drinking water, but they have not paid sufficient attention to DBPs in sewage treatment plants (STPs), where the sources and compositions of DBPs are much more complicated, and there is...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2019.06.034
更新日期:2019-10-15 00:00:00
abstract::The concentration addition (CA) model has been widely applied to predict mixture toxicity. However, its applicability is difficult to evaluate due to the complexity of interactions among substances. Considering that the concentration-response curve (CRC) of each component of the mixture is closely related to the predi...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2014.12.008
更新日期:2015-03-01 00:00:00
abstract::Along with mechanistic models, predictions of exposure-response relationships for copper are often derived from laboratory toxicity experiments with standardized experimental exposures and conditions. For predictions of copper toxicity to algae, cell density is a critical factor often overlooked. For pulse exposures o...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2017.08.010
更新日期:2017-11-01 00:00:00
abstract::The nitrification inhibition test and the luminescent bacteria test were used to determine the inhibiting effect of different phenolic compounds. The chlorinated phenols demonstrated an increased toxicity in the nitrification inhibition test, which was much more sensitive to these compounds than other bacterial toxici...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1006/eesa.1995.1030
更新日期:1995-04-01 00:00:00
abstract::A novel amino-functionalized magnetic adsorbent (Fe3O4@C@DETA) was developed for adsorption of Cr(III) and Cr(III)-EDTA from wastewater. Fe3O4@C@DETA were successfully prepared by modification of Fe3O4@C with diethylenediamine (DETA), which exhibits a core-shell structure and sufficient saturation magnetization. Fe3O4...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111858
更新日期:2021-02-01 00:00:00
abstract::In this study, using a natural and green protein R-phycoerythrin (R-PE) extracted from marine Porphyra yezoensis as the stabilizer and reducer, silver nanoparticles (AgNPs) were synthesized. Based on this, a highly sensitive and selective method for the detection of Cu2+ ions was developed using R-PE-AgNPs as fluoresc...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.10.102
更新日期:2019-01-30 00:00:00
abstract::Box-Behnken model of response surface methodology was used to study the effect of adsorption process parameters for Rhodamine B (RhB) removal from aqueous solution through optimized large surface area date stone activated carbon. The set experiments with three input parameters such as time (10-600min), adsorbent dosag...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2017.02.001
更新日期:2017-05-01 00:00:00
abstract::Nonylphenol (NP) has been classified as an endocrine-disrupting chemical. In this study, we conducted mysid DNA microarray analysis with which has 2240 oligo DNA probes to observe differential gene expressions in mysid crustacean (Americamysis bahia) exposed to 1, 3, 10 and 30 μg/l of NP for 14 days. As a result, we f...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2016.07.037
更新日期:2016-11-01 00:00:00
abstract::The toxicity of nonylphenol (NP) to springtails was pronounced at 40 mg/kg dry weight soil, at which no animals survived. Body length and fecundity were the individual life-history traits significantly stimulated by sublethal concentrations of NP during a 64-day experiment. However, the effects of NP on these traits d...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2006.11.005
更新日期:2007-07-01 00:00:00