Comparison of two empiric antibiotic regimen in late onset neonatal sepsis--a randomized controlled trial.

Abstract:

OBJECTIVE:To compare the effectiveness of two antibiotic regimens among neonates with late onset sepsis (LOS). METHODS:This randomized controlled trial conducted in a tertiary care teaching hospital, South India, included 90 babies with LOS. Detailed history, examination and appropriate investigations were done for all the babies. Cloxacillin + Amikacin were administered to 40 and Cefotaxime + Gentamicin to 50 babies. Outcomes including mortality, complications and treatment failure were evaluated. Chi-square test was used for categorical variables and Student's unpaired t-test for continuous variables. RESULTS:LOS had a male preponderance, and median time of onset was 13 days. Mortality was more among low birth weight babies irrespective of the antibiotics. Predominant bacteria isolated were coagulase-negative staphylococci (26.67%), Escherichia coli (13.33%) and Streptococcus pneumoniae (13.33%). Complications, mortality and cost were similar in both regimens. CONCLUSION:There was no significant difference between the two antibiotic regimens with regard to outcome of LOS.

journal_name

J Trop Pediatr

authors

Ramasamy S,Biswal N,Bethou A,Mathai B

doi

10.1093/tropej/fmt080

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

83-6

issue

1

eissn

0142-6338

issn

1465-3664

pii

fmt080

journal_volume

60

pub_type

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