Pathophysiology of white-nose syndrome in bats: a mechanistic model linking wing damage to mortality.

Abstract:

:White-nose syndrome is devastating North American bat populations but we lack basic information on disease mechanisms. Altered blood physiology owing to epidermal invasion by the fungal pathogen Geomyces destructans (Gd) has been hypothesized as a cause of disrupted torpor patterns of affected hibernating bats, leading to mortality. Here, we present data on blood electrolyte concentration, haematology and acid-base balance of hibernating little brown bats, Myotis lucifugus, following experimental inoculation with Gd. Compared with controls, infected bats showed electrolyte depletion (i.e. lower plasma sodium), changes in haematology (i.e. increased haematocrit and decreased glucose) and disrupted acid-base balance (i.e. lower CO2 partial pressure and bicarbonate). These findings indicate hypotonic dehydration, hypovolaemia and metabolic acidosis. We propose a mechanistic model linking tissue damage to altered homeostasis and morbidity/mortality.

journal_name

Biol Lett

journal_title

Biology letters

authors

Warnecke L,Turner JM,Bollinger TK,Misra V,Cryan PM,Blehert DS,Wibbelt G,Willis CK

doi

10.1098/rsbl.2013.0177

subject

Has Abstract

pub_date

2013-05-29 00:00:00

pages

20130177

issue

4

eissn

1744-9561

issn

1744-957X

pii

rsbl.2013.0177

journal_volume

9

pub_type

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