Abstract:
:Recent years have seen great advances in our understanding of genetic contributors to drug response. Drug discovery and development around targeted genetic (somatic) mutations has led to a number of new drugs with genetic indications, particularly for the treatment of cancers. Our knowledge of genetic contributors to variable drug response for existing drugs has also expanded dramatically, such that the evidence now supports clinical use of genetic data to guide treatment in some situations, and across a variety of therapeutic areas. Clinical implementation of pharmacogenetics has seen substantial growth in recent years and groups are working to identify the barriers and best practices for pharmacogenetic-guided treatment. The advances and challenges in these areas are described and predictions about future use of genetics in drug therapy are discussed.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Johnson JAdoi
10.2217/pgs.13.52subject
Has Abstractpub_date
2013-05-01 00:00:00pages
835-43issue
7eissn
1462-2416issn
1744-8042journal_volume
14pub_type
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