Abstract:
:Ca(2+) influx at critical points in the cell cycle is required for proliferation. This requirement is so ubiquitous that its occurrence is often treated as background noise. Yet without it, cells stop dividing, suggesting an obvious and potentially effective way to treat cancer. To control proliferation by controlling Ca(2+) influx requires that the mechanism be elucidated, but this field of study has been filled with controversy and devoid of therapeutic utility. In this study, the authors present a model for the regulation of Ca(2+) influx at the G1/S restriction point in cancer and stem cells that is simple, cohesive and, we believe, reasonably complete. The model illustrates the essential role of T-type Ca(2+) channels in mediating influx and points clearly to the therapeutic strategies that have recently entered clinical trials.
journal_name
Expert Rev Anticancer Therjournal_title
Expert review of anticancer therapyauthors
Gray LS,Schiff D,Macdonald TLdoi
10.1586/era.13.34subject
Has Abstractpub_date
2013-05-01 00:00:00pages
589-95issue
5eissn
1473-7140issn
1744-8328journal_volume
13pub_type
杂志文章,评审abstract::Cancer-related anorexia/cachexia syndrome is a complex phenomenon in which metabolic abnormalities, proinflammatory cytokines produced by the host immune system, circulating tumor-derived catabolic factors, decreased food intake and probably additional unknown factors all play different roles. This review examines the...
journal_title:Expert review of anticancer therapy
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abstract::Current targeted strategies for cancer focus on the blockade of growth factor receptors and the inhibition of angiogenesis. The VEGF pathway has become an attractive target in multiple malignancies, including lung cancer. Bevacizumab, a monoclonal antibody against VEGF, increased survival in non-small-cell lung cancer...
journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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abstract::Adrenocortical carcinoma is a rare disorder with a prevalence of one case per 1.7 million people and a generally poor prognosis. It accounts for 0.02% of all cancer cases and 0.2% of cancer deaths. Within the past three decades, accurate diagnosis, precise radiologic localization, satisfactory preoperative medical man...
journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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更新日期:2012-12-01 00:00:00
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journal_title:Expert review of anticancer therapy
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更新日期:2012-03-01 00:00:00
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更新日期:2004-06-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
doi:10.1586/14737140.2013.852472
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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