A case of paravertebral mediastinal chordoma without bone destruction.

Abstract:

:We report a unique case of mediastinal paravertebral chordoma without bone destruction in a 47-year-old Japanese woman. She was admitted to hospital after a tumor was incidentally detected on a chest radiograph. The tumor was located in the paravertebral region of the mediastinum and did not show any destruction of the thoracic vertebra radiologically. The tumor was clinically diagnosed as a benign neurogenic tumor and the tumor was easily removed surgically. Microscopically, the tumor mainly consisted of tumor cells with extensively vacuolated cytoplasm, arranged in cord- and nest-like fashion against a myxoid matrix background. Immunohistochemically, the tumor cells showed diffuse positivity for pancytokeratin (AE1/AE3) and vimentin. The tumor cell nuclei were positive for brachyury, which is a key transcription factor of notochordal development. These results confirmed the tumor to be an extraosseous chordoma in the paravertebral mediastinal region, which is an extremely rare location for a chordoma.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Matsubayashi J,Sato E,Nomura M,Kakihana M,Uchida O,Saji H,Park J,Akata S,Ikeda N,Nagao T,Ishida T

doi

10.1007/s00256-012-1493-3

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1641-4

issue

12

eissn

0364-2348

issn

1432-2161

journal_volume

41

pub_type

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