Abstract:
:A novel approach to the pyridoacridine ring system of the ascididemin-type marine alkaloids is presented. This approach allows for the introduction of the ring A of the alkaloids by using a simple aromatic aldehyde building block. The viability of this approach is demonstrated with the synthesis of AK37, a bioactive deaza analogue of the alkaloid ascididemin. Starting from 3-cyano-4-methylquinoline, a sequence of regioselective homolytic benzoylation, annulation of a bromopyridine ring, and radical cyclization leads to the pentacyclic ring system.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Raeder S,Bracher Fdoi
10.1002/ardp.201200019subject
Has Abstractpub_date
2012-10-01 00:00:00pages
822-6issue
10eissn
0365-6233issn
1521-4184journal_volume
345pub_type
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