Abstract:
:The physiology of paracellular permeation of ions and solutes in the kidney is pivotally important but poorly understood. Claudins are the key components of the paracellular pathway. Defects in claudin function result in a broad range of renal diseases, including hypomagnesemia, hypercalciuria and nephrolithiasis. This review describes recent findings on the physiological function of claudins underlying paracellular transport mechanisms with a focus on renal Ca(2+) handling. We have uncovered a molecular mechanism underlying paracellular Ca(2+) transport in the thick ascending limb of Henle (TAL) that involves the functional interplay of three important claudin genes: claudin-14, -16 and -19, all of which are associated with human kidney diseases with hypercalciuria, nephrolithiasis and bone mineral loss. The Ca(2+) sensing receptor (CaSR) signaling in the kidney has long been a mystery. By analyzing small non-coding RNA molecules in the kidney, we have uncovered a novel microRNA based signaling pathway downstream of CaSR that directly regulates claudin-14 gene expression and establishes the claudin-14 molecule as a key regulator for renal Ca(2+) homeostasis. The molecular cascade of CaSR-microRNAs-claudins forms a regulatory loop to maintain proper Ca(2+) homeostasis in the kidney.
journal_name
Organogenesisjournal_title
Organogenesisauthors
Hou Jdoi
10.4161/org.19808subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1-9issue
1eissn
1547-6278issn
1555-8592pii
19808journal_volume
8pub_type
杂志文章,评审相关文献
Organogenesis文献大全abstract::Before we can realize our long term goal of engineering lung tissue worthy of clinical applications, advances in the identification and utilization of cell sources, development of standardized procedures for differentiation of cells, production of matrix tailored to meet the needs of the lung and design of methods or ...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.5.2.8564
更新日期:2009-04-01 00:00:00
abstract::Vascular surgeries such as coronary artery bypass require small diameter vascular grafts with properties that are not available at this time. Approaches using synthetic biomaterials have been not completely successful in producing non-thrombogenic grafts with inner diameters less than 6 mm, and there is a need for new...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.6.4.13407
更新日期:2010-10-01 00:00:00
abstract::Optical projection tomography (OPT) is a technology ideally suited for imaging embryonic organs. We emphasize here recent successes in translating this potential into the field of live imaging. Live OPT (also known as 4D OPT, or time-lapse OPT) is already in position to accumulate good quantitative data on the develop...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.5.4.10426
更新日期:2009-10-01 00:00:00
abstract::We have investigated the microscopic physical inhomogeneity ("texture") of the avian embryo in vivo by shadowgraph. This noninvasive technique allows one to correlate the shape of blood vessels to the physical, micro-structural, pattern that exists in the embryo prior to vessel appearance. Before any vessel forms, vas...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.3.1.3238
更新日期:2007-01-01 00:00:00
abstract::Autophagy has a critical role in liver regeneration. However, no studies have demonstrated autophagic flux in the regenerating fatty liver. The aim of this study was to clarify the dynamics of autophagy in the regeneration of the fatty liver. Following 70% partial hepatectomy (PH) in db/db fatty mice, which is a non-a...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.1080/15476278.2019.1633872
更新日期:2019-01-01 00:00:00
abstract::Very long chain fatty acids are required for sphingolipid synthesis, lipid homeostasis, myelin formation, epidermal permeability, and retinal function. Seven different enzymes are known to be involved in the elongation cycle of fatty acids, with different chain-length specificities. Elovl1 is one of those enzymes whos...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.1080/15476278.2016.1172164
更新日期:2016-04-02 00:00:00
abstract::Cryopreservation would potentially very much facilitate the inventory control and distribution of laboratory-produced organs and tissues. Although simple freezing methods are effective for many simple tissues, bioartificial organs and complex tissue constructs may be unacceptably altered by ice formation and dissoluti...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.5.3.9974
更新日期:2009-07-01 00:00:00
abstract::An injectable, biodegradable and glucose-responsive hydrogel derived from natural polysaccharide derivatives was synthesized to deliver adipogenic factor of insulin in vitro for adipose tissue engineering. The biodegradable hydrogel based N-succinyl-chitosan (SCS) and aldehyde hyaluronic acid (AHA) with covalently con...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.6.3.12037
更新日期:2010-07-01 00:00:00
abstract::Removing the function of a specific gene from a developing organ, by making a 'knockout' mouse, is a powerful method for analyzing the molecular pathways that control organogenesis. The technique is expensive, though, in terms of time and money, and complex strategies for producing conditional knockouts are needed for...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.4.3.6642
更新日期:2008-07-01 00:00:00
abstract::Angiogenesis represents the outgrowth of new blood vessels from existing ones, a physiologic process that is vital to supply nourishment to newly forming tissues during development and tissue remodeling and repair (wound healing). Regulation of angiogenesis in the healthy body occurs through a fine balance of angiogen...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.4.4.6926
更新日期:2008-10-01 00:00:00
abstract::We aimed to investigate the beneficial effect of Celastrol on inner ear stem cells and potential therapeutic value for hearing loss. The inner ear stem cells were isolated and characterized from utricular sensory epithelium of adult mice. The stemness was evaluated by sphere formation assay. The relative expressions o...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.1080/15476278.2018.1462433
更新日期:2018-01-01 00:00:00
abstract::Advances in organ regeneration have been facilitated by gentle decellularization protocols that maintain distinct tissue compartments, and thereby allow seeding of blood vessels with endothelial lineages separate from populations of the parenchyma with tissue-specific cells. We hypothesized that a reconstituted vascul...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.1080/15476278.2015.1067354
更新日期:2015-01-01 00:00:00
abstract::Over the past decade, amniotic fluid-derived stem cells have emerged as a novel, experimental approach for the treatment of a wide variety of congenital anomalies diagnosed either in utero or postnatally. There are a number of unique properties of amniotic fluid stem cells that have allowed it to become a major resear...
journal_title:Organogenesis
pub_type: 杂志文章,评审
doi:10.4161/org.22238
更新日期:2012-07-01 00:00:00
abstract::Wnt/beta-catenin signaling has come to the forefront of liver biology in recent years. This pathway regulates key pathophysiological events inherent to the liver including development, regeneration and cancer, by dictating several biological processes such as proliferation, apoptosis, differentiation, adhesion, zonati...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.4.2.5855
更新日期:2008-04-01 00:00:00
abstract::Cutaneous wound repair in adult mammals typically does not regenerate original dermal architecture. Skin that has undergone repair following injury is not identical to intact uninjured skin. This disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryon...
journal_title:Organogenesis
pub_type: 杂志文章,评审
doi:10.1080/15476278.2015.1086052
更新日期:2015-01-01 00:00:00
abstract::We have developed a method for the decellularization of whole rat livers by perfusion with increasing concentrations of detergents. This procedure resulted in an intact, decellularized organ with an intact liver capsule. These decellularized organs were analyzed by immunohistochemistry, and retained an appropriate dis...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.6.2.11546
更新日期:2010-04-01 00:00:00
abstract::The extracellular matrix (ECM) plays an essential role in organizing tissues, defining their shapes or in presenting growth factors. Their components have been well described in most species, but our understanding of the mechanisms that control ECM remodeling remains limited. Likewise, how the ECM contributes to cellu...
journal_title:Organogenesis
pub_type: 杂志文章,评审
doi:10.4161/org.20261
更新日期:2012-04-01 00:00:00
abstract::Liver transplantation as a treatment for end stage liver failure remains limited in the United States by the number and quality of donor allografts. Static cold storage, the current standard of care for organ storage prior to transplantation, offers no method for assessment or therapeutic modification. Cold ischemia a...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.1080/15476278.2018.1517564
更新日期:2018-01-01 00:00:00
abstract::Anticholinergic drugs are well-known to cause adverse effects, such as constipation, but their effects on baseline contractile activity in the gut driven by slow waves is not well established. In a video-based gastrointestinal motility monitoring (GIMM) system, a mouse's small intestine was placed in Krebs solution an...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.1080/15476278.2017.1295904
更新日期:2017-04-03 00:00:00
abstract::Combining cellular self-alignment within tethered collagen gels with stabilization through subsequent removal of interstitial fluid has yielded a new process for the fabrication of aligned cellular biomaterials. This commentary discusses the generation of engineered neural tissue for peripheral nerve repair using this...
journal_title:Organogenesis
pub_type: 评论,杂志文章,评审
doi:10.4161/org.27487
更新日期:2014-01-01 00:00:00
abstract::The central objective of diabetes research and management is to restore the deficient secretion of insulin, thereby restoring a state of euglycemia and minimizing short- and long-term risks associated with poor glucose control. The development of the artificial pancreas seeks to imitate the action of the pancreatic be...
journal_title:Organogenesis
pub_type: 杂志文章,评审
doi:10.4161/org.7.1.14028
更新日期:2011-01-01 00:00:00
abstract::Broadly multipotent stem cells can be isolated from amniotic fluid by selection for the expression of the membrane stem cell factor receptor c-Kit, a common marker for multipotential stem cells. They have clonogenic capability and can be directed into a wide range of cell types representing the three primary embryonic...
journal_title:Organogenesis
pub_type: 杂志文章,评审
doi:10.4161/org.22426
更新日期:2012-07-01 00:00:00
abstract::The major role of the eye lens is to transmit and focus images onto the retina. For this function, the lens needs to develop and maintain the correct shape, notably, the precise curvature and high-level order and organization of its elements. The lens is mainly comprised of highly elongated fiber cells with hexagonal ...
journal_title:Organogenesis
pub_type: 杂志文章,评审
doi:10.4161/org.7.3.18421
更新日期:2011-07-01 00:00:00
abstract::Xenotransplantation was proposed a long time ago as a possible solution to the world-wide shortage of human organs. For years, researchers in this field have almost exclusively directed their efforts towards combating the immunological barrier that precluded long-term xenograft survival. Studies have been conducted in...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.7578
更新日期:2009-01-01 00:00:00
abstract::To investigate the molecular mechanism underlying taurine-stimulated proliferation and differentiation of cochlear neural stem cells (NSCs) and potential involvement of Sonic Hedgehog (Shh) pathway. The NSCs were characterized with immunofluorescence stained with nestin antibody. Cell viability was determined by MTT a...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.1080/15476278.2018.1477462
更新日期:2018-01-01 00:00:00
abstract::Current interest in the potential use of pancreatic stem-cells in the treatment of insulin dependent diabetes mellitus has led to increased research into normal pancreatic development. Pancreatic organogenesis involves branching morphogenesis of undifferentiated epithelium within surrounding mesenchyme. Current unders...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.1.2.1254
更新日期:2004-10-01 00:00:00
abstract::Metabolomics is one of the relative newcomers of the omics techniques and is likely the one most closely related to actual real-time disease pathophysiology. Hence, it has the power to yield not only specific biomarkers but also insight into the pathophysiology of disease. Despite this power, metabolomics as applied t...
journal_title:Organogenesis
pub_type: 杂志文章,评审
doi:10.4161/org.24322
更新日期:2013-01-01 00:00:00
abstract::Alopecia has several causes, but its relationship with ischemia/hypoxia has not yet been investigated in detail. In this study, we studied the changes of hair follicles induced by ischemia and potential effects of normobaric hyperoxygenation (NBO) on the hair cycle and growth. We found that skin ischemia reduced hair ...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.1080/15476278.2020.1794271
更新日期:2020-07-02 00:00:00
abstract::Cell sheet engineering has enabled the production of confluent cell sheets stacked together for use as a cardiac patch to increase cell survival rate and engraftment after transplantation, thereby providing a promising strategy for high density stem cell delivery for cardiac repair. One key challenge in using cell she...
journal_title:Organogenesis
pub_type: 杂志文章
doi:10.4161/org.28990
更新日期:2014-04-01 00:00:00
abstract::In the recent decades, human genome engineering has been one of the major interesting research subjects, essentially because it raises new possibilities for personalized medicine and biotechnologies. With the development of engineered nucleases such as the Zinc Finger Nucleases (ZFNs), the Transcription activator-like...
journal_title:Organogenesis
pub_type: 杂志文章,评审
doi:10.1080/15476278.2015.1120047
更新日期:2015-01-01 00:00:00