Xenotransplantation as a model of integrated, multidisciplinary research.

abstract：:Combining cellular self-alignment within tethered collagen gels with stabilization through subsequent removal of interstitial fluid has yielded a new process for the fabrication of aligned cellular biomaterials. This commentary discusses the generation of engineered neural tissue for peripheral nerve repair using this...

journal_title：Organogenesis

authors： Phillips JB

更新日期：2014-01-01 00:00:00

abstract：:Isolation of adipose-derived stem cells (ASCs) typically involves 8+ hours of intense effort, requiring specialized equipment and reagents. Here, we present an improved technique for isolating viable populations of mesenchymal stem cells from lipoaspirate saline fractions within 30 minutes. Importantly, the cells exhi...

journal_title：Organogenesis

authors： Francis MP,Sachs PC,Elmore LW,Holt SE

更新日期：2010-01-01 00:00:00

abstract：:Very long chain fatty acids are required for sphingolipid synthesis, lipid homeostasis, myelin formation, epidermal permeability, and retinal function. Seven different enzymes are known to be involved in the elongation cycle of fatty acids, with different chain-length specificities. Elovl1 is one of those enzymes whos...

journal_title：Organogenesis

authors： Bhandari S,Lee JN,Kim YI,Nam IK,Kim SJ,Kim SJ,Kwak S,Oh GS,Kim HJ,Yoo HJ,So HS,Choe SK,Park R

更新日期：2016-04-02 00:00:00

abstract：:In the recent decades, human genome engineering has been one of the major interesting research subjects, essentially because it raises new possibilities for personalized medicine and biotechnologies. With the development of engineered nucleases such as the Zinc Finger Nucleases (ZFNs), the Transcription activator-like...

journal_title：Organogenesis

authors： Tobita T,Guzman-Lepe J,Collin de l'Hortet A

更新日期：2015-01-01 00:00:00

abstract：:Cell sheet engineering has enabled the production of confluent cell sheets stacked together for use as a cardiac patch to increase cell survival rate and engraftment after transplantation, thereby providing a promising strategy for high density stem cell delivery for cardiac repair. One key challenge in using cell she...

journal_title：Organogenesis

authors： Patel NG,Zhang G

更新日期：2014-04-01 00:00:00

abstract：:The physiology of paracellular permeation of ions and solutes in the kidney is pivotally important but poorly understood. Claudins are the key components of the paracellular pathway. Defects in claudin function result in a broad range of renal diseases, including hypomagnesemia, hypercalciuria and nephrolithiasis. Thi...

journal_title：Organogenesis

authors： Hou J

更新日期：2012-01-01 00:00:00

abstract：:Broadly multipotent stem cells can be isolated from amniotic fluid by selection for the expression of the membrane stem cell factor receptor c-Kit, a common marker for multipotential stem cells. They have clonogenic capability and can be directed into a wide range of cell types representing the three primary embryonic...

journal_title：Organogenesis

authors： Cananzi M,De Coppi P

更新日期：2012-07-01 00:00:00

abstract：:Anticholinergic drugs are well-known to cause adverse effects, such as constipation, but their effects on baseline contractile activity in the gut driven by slow waves is not well established. In a video-based gastrointestinal motility monitoring (GIMM) system, a mouse's small intestine was placed in Krebs solution an...

journal_title：Organogenesis

authors： Wong KKL,Tang LCY,Zhou J,Ho V

更新日期：2017-04-03 00:00:00

abstract：:Advances in organ regeneration have been facilitated by gentle decellularization protocols that maintain distinct tissue compartments, and thereby allow seeding of blood vessels with endothelial lineages separate from populations of the parenchyma with tissue-specific cells. We hypothesized that a reconstituted vascul...

journal_title：Organogenesis

authors： Willenberg BJ,Oca-Cossio J,Cai Y,Brown AR,Clapp WL,Abrahamson DR,Terada N,Ellison GW,Mathews CE,Batich CD,Ross EA

更新日期：2015-01-01 00:00:00

abstract：:Wnt/beta-catenin signaling has come to the forefront of liver biology in recent years. This pathway regulates key pathophysiological events inherent to the liver including development, regeneration and cancer, by dictating several biological processes such as proliferation, apoptosis, differentiation, adhesion, zonati...

journal_title：Organogenesis

authors： Nejak-Bowen K,Monga SP

更新日期：2008-04-01 00:00:00

abstract：:Vascular surgeries such as coronary artery bypass require small diameter vascular grafts with properties that are not available at this time. Approaches using synthetic biomaterials have been not completely successful in producing non-thrombogenic grafts with inner diameters less than 6 mm, and there is a need for new...

journal_title：Organogenesis

authors： Lovett M,Eng G,Kluge JA,Cannizzaro C,Vunjak-Novakovic G,Kaplan DL

更新日期：2010-10-01 00:00:00

abstract：:An injectable, biodegradable and glucose-responsive hydrogel derived from natural polysaccharide derivatives was synthesized to deliver adipogenic factor of insulin in vitro for adipose tissue engineering. The biodegradable hydrogel based N-succinyl-chitosan (SCS) and aldehyde hyaluronic acid (AHA) with covalently con...

journal_title：Organogenesis

authors： Tan H,Rubin JP,Marra KG

更新日期：2010-07-01 00:00:00

abstract：:Current interest in the potential use of pancreatic stem-cells in the treatment of insulin dependent diabetes mellitus has led to increased research into normal pancreatic development. Pancreatic organogenesis involves branching morphogenesis of undifferentiated epithelium within surrounding mesenchyme. Current unders...

journal_title：Organogenesis

authors： Lear PV,Jayanthi NV,Teague WJ,Johnson PR

更新日期：2004-10-01 00:00:00

abstract：:Before we can realize our long term goal of engineering lung tissue worthy of clinical applications, advances in the identification and utilization of cell sources, development of standardized procedures for differentiation of cells, production of matrix tailored to meet the needs of the lung and design of methods or ...

journal_title：Organogenesis

authors： Nichols JE,Niles JA,Cortiella J

更新日期：2009-04-01 00:00:00

abstract：:Angiogenesis represents the outgrowth of new blood vessels from existing ones, a physiologic process that is vital to supply nourishment to newly forming tissues during development and tissue remodeling and repair (wound healing). Regulation of angiogenesis in the healthy body occurs through a fine balance of angiogen...

journal_title：Organogenesis

authors： Pardue EL,Ibrahim S,Ramamurthi A

更新日期：2008-10-01 00:00:00

abstract：:The central objective of diabetes research and management is to restore the deficient secretion of insulin, thereby restoring a state of euglycemia and minimizing short- and long-term risks associated with poor glucose control. The development of the artificial pancreas seeks to imitate the action of the pancreatic be...

journal_title：Organogenesis

authors： Gregory JM,Moore DJ

更新日期：2011-01-01 00:00:00

abstract：:The extracellular matrix (ECM) plays an essential role in organizing tissues, defining their shapes or in presenting growth factors. Their components have been well described in most species, but our understanding of the mechanisms that control ECM remodeling remains limited. Likewise, how the ECM contributes to cellu...

journal_title：Organogenesis

authors： Labouesse M

更新日期：2012-04-01 00:00:00

abstract：:The major role of the eye lens is to transmit and focus images onto the retina. For this function, the lens needs to develop and maintain the correct shape, notably, the precise curvature and high-level order and organization of its elements. The lens is mainly comprised of highly elongated fiber cells with hexagonal ...

journal_title：Organogenesis

authors： Sugiyama Y,Lovicu FJ,McAvoy JW

更新日期：2011-07-01 00:00:00

abstract：:We have investigated the microscopic physical inhomogeneity ("texture") of the avian embryo in vivo by shadowgraph. This noninvasive technique allows one to correlate the shape of blood vessels to the physical, micro-structural, pattern that exists in the embryo prior to vessel appearance. Before any vessel forms, vas...

journal_title：Organogenesis

authors： Fleury V,Unbekandt M,Al-Kilani A,Nguyen TH

更新日期：2007-01-01 00:00:00

abstract：:Cutaneous wound repair in adult mammals typically does not regenerate original dermal architecture. Skin that has undergone repair following injury is not identical to intact uninjured skin. This disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryon...

journal_title：Organogenesis

authors： Houschyar KS,Momeni A,Pyles MN,Maan ZN,Whittam AJ,Siemers F

更新日期：2015-01-01 00:00:00

abstract：:Bell shaped nuclei of metakaryotic cells double their DNA content during and after symmetric and asymmetric amitotic fissions rather than in the separate, pre-mitotic S-phase of eukaryotic cells. A parsimonious hypothesis was tested that the two anti-parallel strands of each chromatid DNA helix were first segregated a...

journal_title：Organogenesis

authors： Thilly WG,Gostjeva EV,Koledova VV,Zukerberg LR,Chung D,Fomina JN,Darroudi F,Stollar BD

更新日期：2014-01-01 00:00:00

abstract：:Alopecia has several causes, but its relationship with ischemia/hypoxia has not yet been investigated in detail. In this study, we studied the changes of hair follicles induced by ischemia and potential effects of normobaric hyperoxygenation (NBO) on the hair cycle and growth. We found that skin ischemia reduced hair ...

journal_title：Organogenesis

authors： Kato H,Kinoshita K,Saito N,Kanayama K,Mori M,Asahi N,Sunaga A,Yoshizato K,Itami S,Yoshimura K

更新日期：2020-07-02 00:00:00

abstract：:There is growing evidence that some members of cytochrome P450 enzymes contribute to regulation of normal prenatal development. CYP epoxygenases (CYP2C and CYP2J subfamilies) convert arachidonic acid into four regioisomeric epoxyeicosatrienoic acids (EETs), biologically active molecules involved in mitogenesis and cel...

journal_title：Organogenesis

authors： Cizkova K,Konieczna A,Erdosova B,Ehrmann J

更新日期：2014-01-01 00:00:00

abstract：:Optical projection tomography (OPT) is a technology ideally suited for imaging embryonic organs. We emphasize here recent successes in translating this potential into the field of live imaging. Live OPT (also known as 4D OPT, or time-lapse OPT) is already in position to accumulate good quantitative data on the develop...

journal_title：Organogenesis

authors： Colas JF,Sharpe J

更新日期：2009-10-01 00:00:00

abstract：:To investigate the molecular mechanism underlying taurine-stimulated proliferation and differentiation of cochlear neural stem cells (NSCs) and potential involvement of Sonic Hedgehog (Shh) pathway. The NSCs were characterized with immunofluorescence stained with nestin antibody. Cell viability was determined by MTT a...

journal_title：Organogenesis

authors： Huang X,Wu W,Hu P,Wang Q

更新日期：2018-01-01 00:00:00

abstract：:Removing the function of a specific gene from a developing organ, by making a 'knockout' mouse, is a powerful method for analyzing the molecular pathways that control organogenesis. The technique is expensive, though, in terms of time and money, and complex strategies for producing conditional knockouts are needed for...

journal_title：Organogenesis

authors： Lee WC,Berry R,Hohenstein P,Davies J

更新日期：2008-07-01 00:00:00

abstract：:Autophagy has a critical role in liver regeneration. However, no studies have demonstrated autophagic flux in the regenerating fatty liver. The aim of this study was to clarify the dynamics of autophagy in the regeneration of the fatty liver. Following 70% partial hepatectomy (PH) in db/db fatty mice, which is a non-a...

journal_title：Organogenesis

authors： Matsumoto Y,Yoshizumi T,Toshima T,Takeishi K,Fukuhara T,Itoh S,Ikegami T,Soejima Y,Mori M

更新日期：2019-01-01 00:00:00

abstract：:The ischemia-reperfusion (I/R) induced skin lesion has been identified as primary cause of pressure ulcer. Better understanding of the mechanism is required for new therapy development. Leucine rich repeat containing protein 19 (LRRC19) is a recently discovered transmembrane protein containing leucine-rich repeats and...

journal_title：Organogenesis

authors： Sun J,Wang Z,Wang X

更新日期：2018-01-02 00:00:00

abstract：:We have developed a method for the decellularization of whole rat livers by perfusion with increasing concentrations of detergents. This procedure resulted in an intact, decellularized organ with an intact liver capsule. These decellularized organs were analyzed by immunohistochemistry, and retained an appropriate dis...

journal_title：Organogenesis

authors： Shupe T,Williams M,Brown A,Willenberg B,Petersen BE

更新日期：2010-04-01 00:00:00

abstract：:Over the past decade, amniotic fluid-derived stem cells have emerged as a novel, experimental approach for the treatment of a wide variety of congenital anomalies diagnosed either in utero or postnatally. There are a number of unique properties of amniotic fluid stem cells that have allowed it to become a major resear...

journal_title：Organogenesis

authors： Kunisaki SM

更新日期：2012-07-01 00:00:00