Levels of reactive oxygen metabolites in patients with knee osteoarthritis.

Abstract:

AIM:  Oxidative stress may be associated with the pathophysiology of knee osteoarthritis (OA), a health-care issue. The present study aimed to compare oxidative status levels of patients with and without knee OA, using the Reactive Oxygen Metabolites (d-ROMs, Diacron, Italy) test, which has proved to be clinically useful as an oxidative stress marker. METHODS:  Forty-nine women (mean age 71.3 ± 5.8 years, mean body mass index 24.4 ± 2.2 kg/m(2) ) with mildly severe knee OA and 49, without knee OA, female controls' serum d-ROMs concentrations were assessed together with mean blood pressure, fasting plasma glucose and serum total cholesterol concentrations, using the age-, sex- and body mass index-matched method. RESULTS:  Patients with knee OA showed significantly higher d-ROMs levels than controls (338 ± 56 vs 315 ± 47 U. Carr., P < 0.05). This difference remained statistically significant after adjusting for other clinical variables. CONCLUSIONS:  The present results suggested that knee OA might be an impaired oxidative condition. Further studies are necessary to establish the knee OA-oxidative status relationship, which may lead to its clinical application in the management of knee OA.

journal_name

Australas J Ageing

authors

Kotani K,Sakane N,Kamimoto M,Taniguchi N

doi

10.1111/j.1741-6612.2010.00500.x

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

231-3

issue

4

eissn

1440-6381

issn

1741-6612

journal_volume

30

pub_type

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