Prognostic impact of postoperative serum CA 19-9 levels in patients with resectable pancreatic cancer.

Abstract:

BACKGROUND:Perioperative serum carbohydrate antigen 19-9 (CA 19-9) level has been reported to be a useful prognostic marker in pancreatic cancer. The object of this study was to investigate the predictive factors for survival, including preoperative and postoperative serum CA 19-9 levels in patients with pancreatic cancer. METHODS:Between 2003 and 2009, a total of 269 patients with pancreatic invasive ductal carcinoma underwent macroscopically curative resection, and pre- and postoperative (within 3 months after surgery) serum CA 19-9 levels were evaluated in all of them. The prognostic significance of clinicopathologic factors was evaluated by univariate and multivariate analyses. RESULTS:Preoperative serum CA 19-9 levels were higher than normal (>37 U/ml, 38-4600 U/ml) in 218 of 269 patients. Of these, after surgery, serum CA 19-9 level returned to within a normal range in 136 patients (62%), whereas 82 patients (38%) remained in the higher-than-normal range. In univariate and multivariate analyses, node metastasis (P < 0.001) and postoperative CA 19-9 level (>37 U/ml) (P < 0.0001) were independent predictors for poor survival. Postoperative CA 19-9 level was higher in patients with microscopically positive surgical margin (P = 0.02). Hepatic recurrence and peritoneal dissemination were associated with postoperative higher CA 19-9 level. CONCLUSIONS:Postoperative CA 19-9 level was associated with positive surgical margin and hepatic or peritoneal recurrence and may be a useful predictor for survival in patients with pancreatic cancer.

journal_name

Ann Surg Oncol

authors

Hata S,Sakamoto Y,Yamamoto Y,Nara S,Esaki M,Shimada K,Kosuge T

doi

10.1245/s10434-011-2020-9

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

636-41

issue

2

eissn

1068-9265

issn

1534-4681

journal_volume

19

pub_type

杂志文章
  • Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion.

    abstract:BACKGROUND:Isolated limb infusion (ILI) is a recently described minimally invasive technique developed in Australia for delivering regional chemotherapy. This study examined the efficacy and toxicity of ILI, compared to hyperthermic isolated limb perfusion (HILP), in treating extremity in-transit melanoma. METHODS:Var...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-008-9988-9

    authors: Beasley GM,Petersen RP,Yoo J,McMahon N,Aloia T,Petros W,Sanders G,Cheng TY,Pruitt SK,Seigler H,Tyler DS

    更新日期:2008-08-01 00:00:00

  • The chemokine receptors CXCR4 and CCR7 are associated with tumor size and pathologic indicators of tumor aggressiveness in papillary thyroid carcinoma.

    abstract:BACKGROUND:Functional chemokine receptors are expressed in many malignant tumors, including papillary thyroid carcinoma (PTC). These receptors promote tumor growth and metastasis in response to endogenous chemokines. The purpose of this study was to examine the expression of two chemokine receptors-CXCR4 and CCR7-in a ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0064-2

    authors: Wagner PL,Moo TA,Arora N,Liu YF,Zarnegar R,Scognamiglio T,Fahey TJ 3rd

    更新日期:2008-10-01 00:00:00

  • Radiation Therapy After Breast-Conserving Surgery in Women 70 Years of Age and Older: How Wisely Do We Choose?

    abstract:BACKGROUND:Despite data from randomized trials supporting omission of radiation therapy (RT) for women ≥ 70 years of age with T1, estrogen receptor-positive (ER+) tumors undergoing breast-conserving therapy (BCT), RT usage remains high. We reviewed our institutional experience to determine if risk factors for local rec...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-07151-4

    authors: Downs-Canner S,Zabor EC,Wind T,Cobovic A,McCormick B,Morrow M,Heerdt A

    更新日期:2019-04-01 00:00:00

  • Sentinel Lymph Node Mapping of Liver.

    abstract:BACKGROUND:Although the sentinel lymph node (SLN) hypothesis has been applied to many tissues and organs, liver has remained unstudied. Currently, it is unclear whether hepatic SLNs even exist. If so, they could alter the management of intrahepatic cholangiocarcinoma and other hepatic malignancies by minimizing the ext...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4601-5

    authors: Wada H,Hyun H,Vargas C,Genega EM,Gravier J,Gioux S,Frangioni JV,Choi HS

    更新日期:2015-12-01 00:00:00

  • Association Between Waiting Time from Diagnosis to Treatment and Survival in Patients with Curable Gastric Cancer: A Population-Based Study in the Netherlands.

    abstract:BACKGROUND:In the Netherlands, a maximum waiting time from diagnosis to treatment (WT) of 5 weeks is recommended for curative cancer treatment. This study aimed to evaluate the association between WT and overall survival (OS) in patients undergoing gastrectomy for cancer. METHODS:This nationwide study included data fr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5820-8

    authors: Brenkman HJF,Visser E,van Rossum PSN,Siesling S,van Hillegersberg R,Ruurda JP

    更新日期:2017-07-01 00:00:00

  • Intraoperative epidural analgesia prevents the early proinflammatory response to surgical trauma. Results from a prospective randomized clinical trial of intraoperative epidural versus general analgesia.

    abstract:BACKGROUND:The intraoperative epidural analgesia (EA) has the potential to reduce stress response to surgical trauma which induces a transient immunoactivation that has a negative impact on the outcome. This study investigates the effect of intraoperative EA versus intravenous analgesia (IA) on the immune function. ME...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-011-1700-9

    authors: Moselli NM,Baricocchi E,Ribero D,Sottile A,Suita L,Debernardi F

    更新日期:2011-10-01 00:00:00

  • Relationship between pathologic T-stage and nodal metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer.

    abstract:BACKGROUND:We investigated the relationship between pathologic T-stage and mesorectal metastases after preoperative chemoradiotherapy (CRT) for clinical stage II to III rectal carcinoma. METHODS:The records of consecutive patients with clinical stage II to III carcinoma of the mid or low rectum who underwent surgery a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.03.044

    authors: Pucciarelli S,Capirci C,Emanuele U,Toppan P,Friso ML,Pennelli GM,Crepaldi G,Pasetto L,Nitti D,Lise M

    更新日期:2005-02-01 00:00:00

  • Surgical approach and perioperative complications determine short-term outcomes in patients with insulinoma: results of a bi-institutional study.

    abstract:BACKGROUND:Despite advancements in radiologic imaging and minimally invasive surgery, the evaluation and management of insulinomas is institution and surgeon dependent. Therefore, the reported surgical outcomes are highly variable. We compared the surgical management and outcomes of insulinomas between two internationa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-008-0157-y

    authors: Roland CL,Lo CY,Miller BS,Holt S,Nwariaku FE

    更新日期:2008-12-01 00:00:00

  • Survival among patients with platinum resistant, locally advanced non-small cell lung cancer treated with platinum-based systemic therapy.

    abstract:BACKGROUND:Recent adjuvant chemotherapy trials after resection of stage II and III non-small cell lung cancer (NSCLC) have identified important survival differences among patients with immunohistochemical evidence suggesting platinum resistance. No clinical information exists regarding the impact upon survival of patie...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0608-0

    authors: d'Amato TA,Pettiford BL,Schuchert MJ,Parker R,Ricketts WA,Luketich JD,Landreneau RJ

    更新日期:2009-10-01 00:00:00

  • Laparoscopic Spleen-Preserving Total Pancreatectomy for a Main-Duct Intraductal Papillary Mucinous Neoplasm.

    abstract:INTRODUCTION:Main-duct intraductal papillary mucinous neoplasms of the pancreas (M-IPMN) are potentially malignant cystic neoplasms that can degenerate into invasive malignancy in 43 % of cases.1 Although laparoscopic pancreaticoduodenectomy and distal pancreatectomy have been previously described for the management of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5481-z

    authors: Chapman BC,Paniccia A,Ryan C,Schulick RD,Edil BH

    更新日期:2017-02-01 00:00:00

  • Robot versus laparoscopic gastrectomy for cancer by an experienced surgeon: comparisons of surgery, complications, and surgical stress.

    abstract:BACKGROUND:No previous robotic studies present an equivalent surgical quality comparison in an experienced setting for gastric cancer. In addition, a reliable postoperative complication assessment is needed to accurately evaluate surgical outcomes. METHODS:After 20 cases of robotic-assisted gastrectomy (RAG), a total ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2679-6

    authors: Hyun MH,Lee CH,Kwon YJ,Cho SI,Jang YJ,Kim DH,Kim JH,Park SH,Mok YJ,Park SS

    更新日期:2013-04-01 00:00:00

  • Intraoperative examination of sentinel nodes in breast cancer: is the glass half full or half empty?

    abstract:BACKGROUND:Intraoperative identification of positive sentinel lymph nodes in patients with breast cancer may avoid a return to the operating room. METHODS:In a group of 402 consecutive patients with primary breast cancer who underwent sentinel lymph node biopsy, an intraoperative examination (IE) was obtained in 236 c...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/ASO.2004.12.005

    authors: Fortunato L,Amini M,Farina M,Rapacchietta S,Costarelli L,Piro FR,Alessi G,Pompili P,Bianca S,Vitelli CE

    更新日期:2004-11-01 00:00:00

  • The association of surgical margins and local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy: a meta-analysis.

    abstract:PURPOSE:There is no consensus on what constitutes adequate negative margins in breast-conserving therapy (BCT). We systematically review the evidence on surgical margins in BCT for invasive breast cancer to support the development of clinical guidelines. METHODS:Study-level meta-analysis of studies reporting local rec...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-014-3480-5

    authors: Houssami N,Macaskill P,Marinovich ML,Morrow M

    更新日期:2014-03-01 00:00:00

  • Influence of Food Intake on the Healing Process of Postoperative Pancreatic Fistula After Pancreatoduodenectomy: A Multi-institutional Randomized Controlled Trial.

    abstract:BACKGROUND:The usefulness of enteral nutrition via a nasointestinal tube for patients who develop postoperative pancreatic fistula (POPF) after miscellaneous pancreatectomy procedures has been reported. However, no clear evidence regarding whether oral intake is possible during management of POPF after pancreatoduodene...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1245/s10434-015-4496-1

    authors: Fujii T,Nakao A,Murotani K,Okamura Y,Ishigure K,Hatsuno T,Sakai M,Yamada S,Kanda M,Sugimoto H,Nomoto S,Takeda S,Morita S,Kodera Y

    更新日期:2015-11-01 00:00:00

  • Parietal peritonectomy.

    abstract::Parietal peritonectomy is an initial part of cytoreductive surgery in patients with peritoneal surface malignancy. After this dissection, the necessary visceral resections, other peritonectomy procedures, and perioperative hyperthermic chemotherapy are administered. The parietal peritoneum is an immobile portion of th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2229-2

    authors: Sugarbaker PH

    更新日期:2012-04-01 00:00:00

  • Lymph node ratio: role in the staging of node-positive colon cancer.

    abstract:BACKGROUND:Recent literature has shown that lymph node ratio (LNR) is superior to the number of positive lymph nodes (pLNs) in predicting the prognosis in several malignances other than colon cancer. We hypothesize that LNR may play a similar role in stage III colon cancer. METHODS:We included 24,477 stage III colon c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9716-x

    authors: Wang J,Hassett JM,Dayton MT,Kulaylat MN

    更新日期:2008-06-01 00:00:00

  • Loss of c-met protooncogene in primary and metastatic sites of breast cancer.

    abstract:BACKGROUND:It has been proposed that clones of tumor cells acquire higher metastatic potential as a result of specific genetic alterations. This study was designed to determine the role of the c-met protooncogene in systemic spread by comparing the loss of the c-met protooncogene between primary and metastatic breast c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303675

    authors: Ng EH,Pey HB,Law HY,Ng I,Ji CY,Lin V,Soo KC

    更新日期:1997-09-01 00:00:00

  • Positive Ultrasound-guided Lymph Node Needle Biopsy in Breast Cancer may not Mandate Axillary Lymph Node Dissection.

    abstract:BACKGROUND:The ACOSOG Z0011 (Z11) trial demonstrated that in patients with nonpalpable axillary lymph nodes (LN) and one to two positive sentinel LN (SLN), axillary LN dissection (ALND) is unnecessary.JAMA 305:569-575, [2011], Ann Surg 264:413-42, [2016] The Z11 trial did not require preoperative axillary ultrasound (a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5935-y

    authors: Harris CK,Tran HT,Lee K,Mylander C,Pack D,Rosman M,Tafra L,Umbricht CB,Andrade R,Liang W,Jackson RS

    更新日期:2017-10-01 00:00:00

  • Development and trends of surgical modalities for breast cancer in China: a review of 16-year data.

    abstract:BACKGROUND:Surgery is the most important treatment for nonmetastatic breast cancer; however, the utilization of modern surgical techniques in management of breast cancer in mainland China has not been reported. METHODS:The medical records of 5887 consecutive breast cancer patients treated surgically in the past 16 yea...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9436-2

    authors: Yu KD,Di GH,Wu J,Lu JS,Shen KW,Shen ZZ,Shao ZM

    更新日期:2007-09-01 00:00:00

  • Axillary recurrence after a tumor-positive sentinel lymph node biopsy without axillary treatment: a review of the literature.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) has become standard of care as a staging procedure in patients with invasive breast cancer. A positive SLNB allows completion axillary lymph node dissection (cALND) to be performed. The axillary recurrence rate (ARR) after cALND in patients with positive SLNB is low. Recentl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-012-2490-4

    authors: Francissen CM,Dings PJ,van Dalen T,Strobbe LJ,van Laarhoven HW,de Wilt JH

    更新日期:2012-12-01 00:00:00

  • A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion.

    abstract:BACKGROUND:L-phenylalanine mustard (LPAM) has been the standard for use in regional chemotherapy (RC) for unresectable in-transit melanoma. Preclinical data demonstrated that regional temozolomide (TMZ) may be more effective. METHODS:Patients with AJCC Stage IIIB or IIIC extremity melanoma who failed previous LPAM-bas...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-3887-z

    authors: Beasley GM,Speicher P,Augustine CK,Dolber PC,Peterson BL,Sharma K,Mosca PJ,Royal R,Ross M,Zager JS,Tyler DS

    更新日期:2015-01-01 00:00:00

  • 'Taking control of cancer': understanding women's choice for mastectomy.

    abstract:PURPOSE:Rates of both unilateral (UM) and contralateral prophylactic mastectomy (CPM) for unilateral early-stage breast cancer (ESBC) have been increasing since 2003. Recent studies suggest that this increase may be due to women choosing UM and CPM because of fear. We conducted an in-depth qualitative study to identify...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4033-7

    authors: Covelli AM,Baxter NN,Fitch MI,McCready DR,Wright FC

    更新日期:2015-02-01 00:00:00

  • STC2: a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma.

    abstract:BACKGROUND:We sought to identify genes associated with the progression and metastasis of esophageal squamous-cell cancer by comparing the expression profiles of normal, primary cancer, and metastatic cancer cells isolated with laser microdissection. METHODS:Oligo microarray analysis identified several lymph node-speci...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1271-1

    authors: Kita Y,Mimori K,Iwatsuki M,Yokobori T,Ieta K,Tanaka F,Ishii H,Okumura H,Natsugoe S,Mori M

    更新日期:2011-01-01 00:00:00

  • Cytoreductive surgery under aminolevulinic acid-mediated photodynamic diagnosis plus hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from ovarian cancer and primary peritoneal carcinoma: results of a phase I trial.

    abstract:BACKGROUND:We conducted a phase I clinical trial to evaluate the sensitivity, specificity, and safety of cytoreductive surgery (CRS) under aminolevulinic acid-mediated photodynamic diagnosis (ALA-PDD) plus hyperthermic intraperitoneal chemotherapy (HIPEC) on 20 patients with peritoneal carcinomatosis (PC) from ovarian ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3901-5

    authors: Liu Y,Endo Y,Fujita T,Ishibashi H,Nishioka T,Canbay E,Li Y,Ogura S,Yonemura Y

    更新日期:2014-12-01 00:00:00

  • De Novo Secondary Adenocarcinoma in the Colon Used as Urinary Diversion Not in Contact with the Fecal Stream: Systematic Review and Meta-analysis.

    abstract:BACKGROUND:A systematic review with a meta-analysis was performed to determine the prevalence and risk factors for secondary de novo adenocarcinoma in the colon used as a urinary diversion not exposed to the fecal stream. METHODS:The systematic review of the literature identified 47 patients with secondary adenocarcin...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08300-4

    authors: Sterpetti AV,Costi U,Grande R,D'Ermo G,Sapienza P

    更新日期:2020-08-01 00:00:00

  • Factors associated with local-regional failure after definitive chemoradiation for locally advanced esophageal cancer.

    abstract:BACKGROUND:Locally advanced esophageal cancer is often treated with a trimodality approach. While a substantial proportion of such patients initially achieve a clinical complete response (cCR) after chemoradiation, only a small proportion achieve durable control. We analyzed patients who reached cCR after definitive ch...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3303-0

    authors: Amini A,Ajani J,Komaki R,Allen PK,Minsky BD,Blum M,Xiao L,Suzuki A,Hofstetter W,Swisher S,Gomez D,Liao Z,Lee JH,Bhutani MS,Welsh JW

    更新日期:2014-01-01 00:00:00

  • Changes in psychosocial functioning 1 year after mastectomy alone, delayed breast reconstruction, or immediate breast reconstruction.

    abstract:BACKGROUND:In this study, we report on the changes in psychosocial functioning over 1 year following breast cancer surgery in 3 groups of women, including those with mastectomy alone, those with mastectomy and immediate reconstruction, and those with delayed reconstruction. METHODS:Women with breast cancer at 2 teachi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-011-1828-7

    authors: Metcalfe KA,Semple J,Quan ML,Vadaparampil ST,Holloway C,Brown M,Bower B,Sun P,Narod SA

    更新日期:2012-01-01 00:00:00

  • Total Laparoscopic Uncut Roux-en-Y for Radical Distal Gastrectomy: An Interim Analysis of a Randomized, Controlled, Clinical Trial.

    abstract:BACKGROUND:The traditional Billroth II and Roux-en-Y anastomosis after laparoscopic distal gastrectomy for gastric cancer are associated with bile reflux gastritis and roux stasis syndrome, respectively. The uncut Roux-en-Y gastrojejunostomy can decrease the incidence of these complications by blocking the entry of bil...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08710-4

    authors: Wang J,Wang Q,Dong J,Yang K,Ji S,Fan Y,Wang C,Ma Q,Wei Q,Ji G

    更新日期:2021-01-01 00:00:00

  • Clinical Significance of Gross Invasion of Strap Muscles in Patients With 1- to 4-cm-Sized Papillary Thyroid Carcinoma Undergoing Lobectomy.

    abstract:BACKGROUND:Given the emerging evidence supporting the lack of prognostic significance of gross extrathyroidal extension invading only strap muscles (strap-gETE), this study investigated whether lobectomy is feasible for patients with strap-gETE. METHODS:A retrospective cohort study was conducted with 636 patients who ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07778-x

    authors: Song E,Kim WW,Jeon MJ,Sung TY,Song DE,Kim TY,Chung KW,Kim WB,Shong YK,Hong SJ,Lee YM,Kim WG

    更新日期:2019-12-01 00:00:00

  • Survival data justifies resection for pancreatic metastases.

    abstract:BACKGROUND:Pancreatic metastases are uncommon and little is known about the oncologic outcome after resection or prognostic parameters. This study was designed to evaluate perioperative and follow-up results after resection for pancreatic metastases and to define prognostic factors. METHODS:From a prospective database...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0682-3

    authors: Strobel O,Hackert T,Hartwig W,Bergmann F,Hinz U,Wente MN,Fritz S,Schneider L,Büchler MW,Werner J

    更新日期:2009-12-01 00:00:00