Abstract:
:A facile synthesis of a series of saccharide-binding arylboronic acid derivatives of indoloquinoline was described. The key synthetic steps were polyphosphoric acid-mediated cyclization, chlorinative aromatization, and amidation. Mass spectrometry experiments revealed these synthetic arylboronic acid derivatives of indoquinolines could bind to biologically important carbohydrates (sialic acid, fucose, glucose, and galactose) by forming boronate di-esters in alkaline aqueous solution. Most of the arylboronic acid derivatives of indoquinolines inhibited human breast cancer cell (MDA-231) proliferation at a concentration of 5 μm, whereas the compound 17 exhibited highest percentages (76.74%) of the cancer cell proliferation inhibition.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Meng J,Yu S,Wan S,Ren S,Jiang Tdoi
10.1111/j.1747-0285.2011.01196.xsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
816-25issue
5eissn
1747-0277issn
1747-0285journal_volume
78pub_type
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