Abstract:
BACKGROUND:In addition to providing phylogenetic relationships, tree making procedures such as parsimony and maximum likelihood can make specific predictions of actual historical sequences. Resurrection of such sequences can be used to understand early events in evolution. In the case of RNA, the nature of parsimony is such that when applied to multiple RNA sequences it typically predicts ancestral sequences that satisfy the base pairing constraints associated with secondary structure. The case for such sequences being actual ancestors is greatly improved, if they can be shown to be biologically functional. RESULTS:A unique common ancestral sequence of 28 Vibrio 5S ribosomal RNA sequences predicted by parsimony was resurrected and found to be functional in the context of the E. coli cellular environment. The functionality of various point variants and intermediates that were constructed as part of the resurrection were examined in detail. When separately introduced the changes at single stranded positions and individual double variants at base-paired positions were also viable. An additional double variant was examined at a different base-paired position and it was also valid. CONCLUSIONS:The results show that at least in the case of the 5S rRNAs considered here, ancestors predicted by parsimony are likely to be realistic when the prediction is not overly influenced by single outliers. It is especially noteworthy that the phenotype of the predicted ancestors could be anticipated as a cumulative consequence of the phenotypes of the individual variants that comprised them. Thus, point mutation data is potentially useful in evaluating the reasonableness of ancestral sequences predicted by parsimony or other methods. The results also suggest that in the absence of significant tertiary structure constraints double variants that preserve pairing in stem regions will typically be accepted. Overall, the results suggest that it will be feasible to resurrect additional meaningful 5S rRNA ancestors as well as ancestral sequences of many different types of RNA.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Lu Q,Fox GEdoi
10.1186/1471-2148-11-218subject
Has Abstractpub_date
2011-07-22 00:00:00pages
218issn
1471-2148pii
1471-2148-11-218journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Retrotransposons have been suggested to provide a substrate for non-allelic homologous recombination (NAHR) and thereby promote gene family expansion. Their precise role, however, is controversial. Here we ask whether retrotransposons contributed to the recent expansions of the Androgen-binding protein (Abp)...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-13-107
更新日期:2013-05-29 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-14-148
更新日期:2014-06-30 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-5-39
更新日期:2005-06-29 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-9-178
更新日期:2009-07-29 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2015-12-21 00:00:00
abstract:BACKGROUND:Modern flamingos (Phoenicopteridae) occupy a highly specialized ecology unique among birds and represent a potentially powerful model system for informing the mechanisms by which a lineage of birds adapts and radiates. However, despite a rich fossil record and well-studied feeding morphology, molecular inves...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-14-36
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-30 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-8-244
更新日期:2008-09-02 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-06 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2013-11-27 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-6-101
更新日期:2006-11-23 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-7-178
更新日期:2007-09-27 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2011-11-15 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-1-8
更新日期:2001-10-20 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2012-12-08 00:00:00
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pub_type: 杂志文章
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更新日期:2011-12-16 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-7-165
更新日期:2007-09-14 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-016-0806-x
更新日期:2016-10-28 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-016-0662-8
更新日期:2016-04-23 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2014-10-04 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-12-36
更新日期:2012-03-19 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2007-01-25 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2003-06-05 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2016-04-14 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-8-343
更新日期:2008-12-29 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2004-07-06 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-12-203
更新日期:2012-10-12 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2010-11-18 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2007-06-26 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2011-06-20 00:00:00