Abstract:
:Only two genome-wide association (GWA) screens have been published for melanoma (Nat Genet 47:920-925, 2009; Nat Genet 40:838-840, 2008). Using a unique approach, we performed a genome-wide association study in 156 related melanoma cases from 34 high-risk Utah pedigrees. Genome-wide association analysis was performed on nearly 500,000 markers; we compared cases to 2,150 genotypically matched samples from Illumina's iControls database. We performed genome-wide association with EMMAX software, which is designed to account for population structure, including relatedness between cases. Three SNPs exceeded a genome-wide significance threshold of p < 5 × 10(-8) on chromosome arm 10q25.1 (rs17119434, rs17119461, and rs17119490), where the most extreme p value was 7.21 × 10(-12). This study represents a new and unique approach to predisposition gene identification; and it is the first genome-wide association study performed in related cases in high-risk pedigrees. Our approach illustrates an example of using high-risk pedigrees for the identification of new melanoma predisposition variants.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Teerlink C,Farnham J,Allen-Brady K,Camp NJ,Thomas A,Leachman S,Cannon-Albright Ldoi
10.1007/s00439-011-1048-zsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
77-85issue
1eissn
0340-6717issn
1432-1203journal_volume
131pub_type
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