Abstract:
STUDY DESIGN:Vertebral growth plates at different postnatal ages were assessed for active intercellular signaling pathways. OBJECTIVE:To generate a spatial and temporal map of the major signaling pathways active in the postnatal mouse lumbar vertebral growth plate. SUMMARY OF BACKGROUND DATA:The growth of all long bones is known to occur by cartilaginous growth plates. The growth plate is composed of layers of chondrocyets that actively proliferate, differentiate, die and, are replaced by bone. The role of major cell signaling pathways has been suggested for regulation of the fetal long bones. But not much is known about the molecular or cellular signals that control the postnatal vertebral growth plate and hence postnatal vertebral bone growth. Understanding such molecular mechanisms will help design therapeutic treatments for vertebral growth disorders such as scoliosis. METHODS:Antibodies against activated downstream intermediates were used to identify cells in the growth plate responding to BMP, TGFβ, and FGF in cryosections of lumbar vertebrae from different postnatal age mice to identify the zones that were responding to these signals. Reporter mice were used to identify the chondrocytes responding to hedgehog (Ihh), and Wnt signaling. RESULTS:We present a spatial/temporal map of these signaling pathways during growth, and differentiation of the mouse lumbar vertebral growth plate. CONCLUSION:During growth and differentiation of the vertebral growth plate, its different components respond at different times to different intercellular signaling ligands. Response to most of these signals is dramatically downregulated at the end of vertebral growth.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Dahia CL,Mahoney EJ,Durrani AA,Wylie Cdoi
10.1097/BRS.0b013e3181f7a3casubject
Has Abstractpub_date
2011-06-15 00:00:00pages
1071-80issue
14eissn
0362-2436issn
1528-1159journal_volume
36pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:Systematic review and meta-analysis. OBJECTIVE:To compare the treatment effects of observational studies versus randomized controlled trials (RCTs) in cervical disc arthroplasty. SUMMARY OF BACKGROUND DATA:RCTs can be logistically challenging and sometimes insufficiently generalizable; well-designed obse...
journal_title:Spine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/BRS.0000000000001377
更新日期:2016-03-01 00:00:00
abstract:STUDY DESIGN:This study prospectively analyzed gait in 21 patients with flatback and reviewed radiographs and charts. OBJECTIVE:To analyze the effect of sagittal imbalance on gait and hip and knee joints. SUMMARY OF BACKGROUND DATA:Loss of lumbar lordosis causes anterior displacement of the center of gravity, which c...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/00007632-200211010-00005
更新日期:2002-11-01 00:00:00
abstract:STUDY DESIGN:A retrospective clinical study. OBJECTIVE:The purpose of this study was to identify risk factors for postoperative distal adding-on in Lenke 1A adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA:Distal adding-on is a postoperative complication associated with the Lenke type 1A curve. Although va...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002722
更新日期:2018-09-01 00:00:00
abstract::Curve patterns and surgical treatment in 118 consecutive patients with post-poliomyelitic paralytic scoliosis are reviewed. The typical curve pattern was double structural curves, usually including the lumbar spine. Modifying the incision and altering the sequence of instrumentation facilitated both the exposure and i...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198111000-00008
更新日期:1981-11-01 00:00:00
abstract:STUDY DESIGN:This case report shows primary natural killer (NK)/T-cell lymphoma originating in the spine as the first case of successful treatment with autologous stem cell transplantation, along with case presentation and literature review. OBJECTIVE:For the proper treatment of this spinal tumor, the pathologic confi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3182407b0b
更新日期:2012-05-01 00:00:00
abstract:STUDY DESIGN:Survey. OBJECTIVE:The aim of this study was to objectify the burden of adolescent idiopathic scoliosis (AIS) to better advocate for scoliosis care in the future. SUMMARY OF BACKGROUND DATA:AIS is a common spinal deformity that can affect individuals on many levels. Patients with big curves usually seek m...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001708
更新日期:2017-01-15 00:00:00
abstract:STUDY DESIGN:The surgically relevant osseous anatomy of the human anatomy was carefully studied and described. The stability of cortical and cancellous screws placed in anatomic sites commonly used for internal fixation of the occiput was tested. OBJECTIVES:To define the bony anatomy of the occiput in quantitative ter...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199805150-00005
更新日期:1998-05-15 00:00:00
abstract:STUDY DESIGN:A cadaveric study OBJECTIVE.: The aim of this study was to analyze the in situ macro- and microscopic configuration of the type II cyst and its anatomic relationship with surrounding structures. SUMMARY OF BACKGROUND DATA:The lack of consensus of surgical strategy to manage symptomatic type II meningeal c...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001587
更新日期:2016-10-15 00:00:00
abstract:STUDY DESIGN:Human intervertebral disc tissue from the annulus was obtained in a prospective study investigating the ultrastructural features of disc cells and extracellular matrix. Experimental studies were approved by the authors' Human Subjects Institutional Review Board. Discs were obtained from surgical specimens ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200204150-00004
更新日期:2002-04-15 00:00:00
abstract:STUDY DESIGN:Retrospective review. OBJECTIVE:To define the geographic variation in costs of anterior cervical discectomy and fusion (ACDF) and posterolateral fusion (PLF). SUMMARY OF BACKGROUND DATA:ACDF and lumbar PLF are common procedures that are used in the treatment of spinal pathologies. To optimize value, both...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001022
更新日期:2015-09-01 00:00:00
abstract:STUDY DESIGN:Mechanical and microcomputed tomography (micro-CT) study of cadaver spines. OBJECTIVE:To compare porosity and thickness of vertebral endplates with (1) compressive stresses measured in adjacent intervertebral discs and (2) grade of disc degeneration. SUMMARY OF BACKGROUND DATA:Endplate porosity is import...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000925
更新日期:2015-08-01 00:00:00
abstract:STUDY DESIGN:Multicenter, prospective, consecutive clinical series. OBJECTIVE.: To report on the use and outcomes of preoperative magnetic resonance imaging (MRI) in a prospective cohort study of 2206 children undergoing posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis. SUMMARY OF BACKGR...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0b013e3181da218c
更新日期:2011-04-15 00:00:00
abstract:STUDY DESIGN:Ninety-six male adult CD-1 mice were randomly divided into sham, spinal cord injury (SCI) + vehicle, and SCI + IPA-3 groups. Expression of matrix metalloproteinase (MMP)-2 and MMP-9, production of tumor necrosis factors (TNF)-α and interleukin (IL)-1β, tissue edema, blood-spinal cord barrier penetrability,...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001491
更新日期:2016-06-01 00:00:00
abstract:STUDY DESIGN:Posture and motion analysis after a Cotrel-Dubousset instrumentation. OBJECTIVES:To investigate the compensation role of pelvis. SUMMARY OF BACKGROUND DATA:Few existing studies found no compensation at the lower unfused level but did not investigate the pelvis. METHODS:Thirty patients were analyzed befo...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000219402.01636.87
更新日期:2006-05-20 00:00:00
abstract:STUDY DESIGN:Measurement of the kinematics of the lumbar spine after insertion of an interspinous spacer in vitro. OBJECTIVES:To understand the kinematics of the instrumented and adjacent levels due to the insertion of this interspinous implant. SUMMARY OF BACKGROUND DATA:An interspinous spacer (X Stop, SFMT, Concord...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000084877.88192.8E
更新日期:2003-10-01 00:00:00
abstract:STUDY DESIGN:Analysis of clinical database material collected prospectively. OBJECTIVE:Examination of the association between lateralization of scoliotic curves and the existence of underlying disease. SUMMARY OF BACKGROUND DATA:It has been suggested that left thoracic scoliosis configurations are intrinsically patho...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199906150-00010
更新日期:1999-06-15 00:00:00
abstract:STUDY DESIGN:Case report and review of relevant literature. OBJECTIVE:To report a rare complication of esophageal perforation in cervical fracture patient with progressive ankylosing spondylitis (AS) and review of relevant literature. SUMMARY OF BACKGROUND DATA:Esophageal perforation in cervical fracture is extremely...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0000000000001885
更新日期:2016-11-15 00:00:00
abstract:STUDY DESIGN:A retrospective case control analysis of 48 cases of postoperative infection following spinal procedures. OBJECTIVES:Spinal procedures that became infected after surgery were analyzed to identify the significance of preoperative and intraoperative risk factors. Characterization of the nature and timing of...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000166532.58227.4f
更新日期:2005-06-15 00:00:00
abstract:STUDY DESIGN:Magnetic resonance imaging findings of an increased signal in the cervical cord in patients undergoing surgery for ossification of the posterior longitudinal ligament were analyzed to determined whether an increased signal on T2-weighted images correlated with a poorer outcome. OBJECTIVES:To clarify wheth...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199801010-00008
更新日期:1998-01-01 00:00:00
abstract:STUDY DESIGN:Prospective clinical study. OBJECTIVE:To investigate the effect of depressive symptoms on the surgery outcome on 2-year follow-up among lumbar spinal stenosis (LSS) patients. SUMMARY OF BACKGROUND DATA:Previous research has suggested an association between preoperative depressive symptoms and a poorer su...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181dcaf4a
更新日期:2011-04-15 00:00:00
abstract:STUDY DESIGN:A cross-sectional study. OBJECTIVE:To investigate bone mineral density (BMD) and the change of bone turnover rate in postmenopausal women with lumbar spinal stenosis (LSS). SUMMARY OF BACKGROUND DATA:Symptomatic LSS prevents elderly patients from performing daily activities because of back pain and neuro...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181829fca
更新日期:2008-10-15 00:00:00
abstract:STUDY DESIGN:A report of a case of lumbar spine duplication with the clinical appearance of adolescent scoliosis. OBJECTIVE:To increase knowledge about the pathogenesis and treatment of lumbar spinal duplication. SUMMARY OF BACKGROUND DATA:Although there have been other reports of lumbar spine duplication of this mag...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199802150-00021
更新日期:1998-02-15 00:00:00
abstract:STUDY DESIGN:A multiple-comparative study between normal and low back pain (LBP) patients before and after rehabilitation. OBJECTIVE:To examine whether there is a change in flexion-relaxation phenomenon in sitting in LBP patient following a rehabilitation treatment. SUMMARY OF BACKGROUND DATA:There is an association ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181ba021e
更新日期:2010-07-15 00:00:00
abstract:STUDY DESIGN:A prospective comparative imaging study. OBJECTIVE:This study investigated whether postoperative resolution of spinal cord increased signal intensity (ISI) reflected symptom improvement and surgical outcomes in cervical spondylotic myelopathy (CSM) patients. SUMMARY OF BACKGROUND DATA:Although some CSM p...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003128
更新日期:2019-11-01 00:00:00
abstract:STUDY DESIGN:Cost-utility analysis of an annular closure device (ACD) based on data from a prospective, multicenter randomized controlled trial (RCT) OBJECTIVE.: The aim of this study was to determine the cost-effectiveness of a novel ACD in a patient population at high risk for recurrent herniation following discectom...
journal_title:Spine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/BRS.0000000000002746
更新日期:2019-01-01 00:00:00
abstract:STUDY DESIGN:A retrospective case series. OBJECTIVE:The aim of this study was to evaluate patients with cervical spine osteomyelitis who underwent multilevel (≥2) subaxial corpectomies and anterior column reconstruction and plating. SUMMARY OF BACKGROUND DATA:Neglected multilevel subaxial cervical osteomyelitis is a ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001557
更新日期:2016-09-15 00:00:00
abstract::Effects of subject positions on range and repeatability of thoracic and lumbar forward flexion, extension, and lateral flexion were studied. Inclinometric methods were used, and 27 subjects were measured by two trained testers. No great differences in repeatability and range of movements were found between measurement...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199109000-00016
更新日期:1991-09-01 00:00:00
abstract:STUDY DESIGN:Pain drawings were scored and their relationship to discographic pain responses was investigated. OBJECTIVES:The purpose of this study was to determine if there was a relationship between patients indicating pain in nonanatomic patterns on pain drawings (possibly suggestive of a tendency to overreport pai...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199503150-00015
更新日期:1995-03-15 00:00:00
abstract:OBJECTIVES:The purposes of this study were to evaluate the nature of the paraspinal soft tissue mass and the location of the lesion involved using magnetic resonance imaging and to correlate these observations with surgical findings. SUMMARY OF BACKGROUND DATA:In the past, tuberculous spondylitis was diagnosed by plai...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199411000-00016
更新日期:1994-11-01 00:00:00
abstract::Present disability evaluation schedules for the low back are not scientifically based and produce very great interexaminer differences. The authors have developed a new impairment schedule based on a comprehensive review of the medical literature and the collected opinions of a large number of back specialists. Tests ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198803000-00019
更新日期:1988-03-01 00:00:00