The spectrum of invasive pneumococcal disease at an adult tertiary care hospital in the early 21st century.

Abstract:

:Despite widespread pneumococcal vaccination of children and adults, invasive pneumococcal disease (IPD) remains prominent. Using our database of all Streptococcus pneumoniae infections at the Veterans Affairs Medical Center, Houston, Texas, since 2000, we reviewed cases of IPD, defined as the isolation of pneumococci from any normally sterile body site. In 136 cases, the mean age of patients was 63 years; 43% were African American, a higher proportion than the 30% served by our hospital. One hundred sixteen patients (85%) had pneumonia, of whom 3 also had empyema. Seven had bacteremia with no apparent source, 5 meningitis, 5 spontaneous bacterial peritonitis, 3 septic arthritis, 2 endocarditis, and individual patients had osteomyelitis and/or localized abscesses. One hundred twenty-one patients (89%) had > or =1 underlying condition associated with susceptibility to pneumococcal infection, and another 8 (6%) were aged >65 years old. Thus only 5% of patients lacked a condition for which 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended. Fifty-five percent had been vaccinated; similar proportions of vaccine serotypes infected previously vaccinated and nonvaccinated patients. All but 2 isolates were fully susceptible to penicillin and cefotaxime as currently defined. Consistent with substantial replacement of infecting serotypes since the introduction of 7-valent pneumococcal conjugate vaccine (PCV7), none of the predominant infecting serotypes was included in PCV7, although all except for 6A were contained in PPV23. The overall mortality at 30 days was 16% and was similar in vaccinated and nonvaccinated subjects. IPD causes a wide spectrum of disease. Mortality is substantial. PPV23 is clearly not fully protective.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Rueda AM,Serpa JA,Matloobi M,Mushtaq M,Musher DM

doi

10.1097/MD.0b013e3181f2b824

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

331-336

issue

5

eissn

0025-7974

issn

1536-5964

pii

00005792-201009000-00007

journal_volume

89

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Severity of systemic sclerosis-associated pulmonary arterial hypertension in African Americans.

    abstract::African Americans (AA) with systemic sclerosis (SSc) have a worse prognosis compared to Americans of European descent (EA). We conducted the current study to test the hypothesis that AA patients with SSc have more severe disease and poorer outcomes compared to EA patients when afflicted with pulmonary arterial hyperte...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000032

    authors: Blanco I,Mathai S,Shafiq M,Boyce D,M Kolb T,Chami H,K Hummers L,Housten T,Chaisson N,L Zaiman A,M Wigley F,J Tedford R,A Kass D,Damico R,E Girgis R,M Hassoun P

    更新日期:2014-07-01 00:00:00

  • A retrospective study of transcutaneous vagus nerve stimulation for poststroke epilepsy.

    abstract:BACKGROUND:This study assessed the effect transcutaneous vagus nerve stimulation (TVNS) for poststroke epilepsy (PSE). METHODS:Fifty-two patients with PSE were included in this study. Twenty-seven patients received TVNS, 30 minutes each session, once daily, twice weekly for a total of 4 weeks; and were assigned to the...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011625

    authors: Song GF,Wang HY,Wu CJ,Li X,Yang FY

    更新日期:2018-08-01 00:00:00

  • Hand metastasis in a patient with cervical cancer: A case report.

    abstract:INTRODUCTION:Acrometastasis is infrequent and generally indicates a wider spread of metastasis with poor prognosis. The diagnosis is challenging, as it might mimic an infectious, inflammatory, or metabolic disease. Acrometastasis are most commonly found in patients with lung, gastrointestinal, kidney, and breast cancer...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020897

    authors: Gallardo-Alvarado L,Ramos AA,Perez-Montiel D,Ramirez-Morales R,Diaz E,Leon DC

    更新日期:2020-07-02 00:00:00

  • S-1 and Cisplatin With or Without Nimotuzumab for Patients With Untreated Unresectable or Metastatic Gastric Cancer: A Randomized, Open-Label Phase 2 Trial.

    abstract::This open-label, randomized phase II trial was performed to compare the efficacy and safety of nimotuzumab plus S-1 and cisplatin (NCS) versus S-1 and cisplatin (CS) alone in patients with untreated unresectable or metastatic gastric cancer in the first-line setting. Eligible participants were randomly assigned (1:1) ...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000000958

    authors: Du F,Zheng Z,Shi S,Jiang Z,Qu T,Yuan X,Sun Y,Song Y,Yang L,Zhao J,Wang J,Chi Y

    更新日期:2015-06-01 00:00:00

  • Topical use of tranexamic acid can effectively decrease hidden blood loss during posterior lumbar spinal fusion surgery: A retrospective study.

    abstract::In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion su...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008233

    authors: Ren Z,Li S,Sheng L,Zhuang Q,Li Z,Xu D,Chen X,Jiang P,Zhang X

    更新日期:2017-10-01 00:00:00

  • Evaluation of dexmedetomidine in combination with sufentanil or butorphanol for postoperative analgesia in patients undergoing laparoscopic resection of gastrointestinal tumors: A quasi-experimental trial.

    abstract::The aim of this study was to evaluate the efficacy of dexmedetomidine in combination with sufentanil or butorphanol for postoperative analgesia in patients undergoing laparoscopic resection of a gastrointestinal tumor.This quasi-experimental trial was conducted in Nanchang, China, from January 2014 to December 2015. E...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000005604

    authors: Zhang XK,Chen QH,Wang WX,Hu Q

    更新日期:2016-12-01 00:00:00

  • Can laparoscopic surgery be applied in gastric gastrointestinal stromal tumors located in unfavorable sites?: A study based on the NCCN guidelines.

    abstract::This article investigated the feasibility of laparoscopic surgery in unfavorable site gastric gastrointestinal stromal tumors (GISTs).We identified 214 patients who underwent primary gastric GIST resection at our institution (January 2006-December 2014) from a prospectively collected database. These patients were divi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006535

    authors: Huang CM,Chen QF,Lin JX,Lin M,Zheng CH,Li P,Xie JW,Wang JB,Lu J,Chen QY,Cao LL,Tu RH

    更新日期:2017-04-01 00:00:00

  • Neutrophil to lymphocyte ratio predicts island sign in patients with intracranial hemorrhage.

    abstract::Our previously studies indicated that inflammatory responses are involved in the hematoma expansion (HE) after intracranial hemorrhage (ICH) ictus. Here, we aim to evaluate the correlations among the ratio of neutrophil to lymphocyte ratio (NLR), HE, and island sign in patients with ICH.Patients with spontaneous ICH w...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013057

    authors: Zhang F,Qian J,Tao C,Wang Y,Lin S,You C,Yang M

    更新日期:2018-11-01 00:00:00

  • Tension band wiring for proximal femoral varus osteotomy fixation in children.

    abstract::For proximal varus osteotomy of the femur in children, a stable fixation, is a concern regarding the safety and the protection of the surgery. The methods of fixation are mostly represented by plating systems; however, the tension band wiring is a simple and eligible option for fixation of proximal femur osteotomy. Th...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000061

    authors: Maranho DA,Pagnano RG,Volpon JB

    更新日期:2014-08-01 00:00:00

  • IL-35-producing B cells in gastric cancer patients.

    abstract::A significant characteristic of advanced gastric cancer (GC) is immune suppression, which can promote the progression of GC. Interleukin 35 (IL-35) is an immune-suppressing cytokine, and it is generally recognized that this cytokine is secreted by regulatory T (Treg) cells. Recently, studies have found that IL-35 can ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010710

    authors: Wang K,Liu J,Li J

    更新日期:2018-05-01 00:00:00

  • Thoracolumbar traumatic nucleus pulposus sequestration combined with a slight flexion distraction fracture: A rare case report and literature review.

    abstract:RATIONALE:Traumatic nucleus pulposus sequestration (TNPS) usually occurs concurrently with severe destruction of bone. TNPS combined with a slight thoracolumbar flexion- distraction fracture, triggering a disastrous nerve injury, has rarely been reported. Due to the atypical radiologic manifestations, such a patient ca...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010952

    authors: Yin R,Chang P,Zhu Q,Cheng F,Zhao B,Gu R,Zhang BY

    更新日期:2018-06-01 00:00:00

  • Prospective comparison of preference and efficacy of adalimumab and infliximab for treating ulcerative colitis naive to antitumor necrosis factor therapy.

    abstract::There have been few reports on 2 tumor necrosis factor alpha inhibitors, infliximab and adalimumab, with respect to patient preference and efficacy in ulcerative colitis (UC).We used questionnaires to evaluate the preference and reasons for drug choice between infliximab and adalimumab in UC patients naive to antitumo...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007800

    authors: Mizoshita T,Katano T,Tanida S,Hirano A,Miyaki T,Ozeki K,Suzuki Y,Sugimura N,Kataoka H,Joh T

    更新日期:2017-08-01 00:00:00

  • Management of placental site trophoblastic tumor: Two case reports.

    abstract:RATIONALE:Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to a family of pregnancy-related illnesses, called gestational trophoblastic diseases (GTD). Less than 300 cases of PSTT have been reported in literature, with an incidence of ≈ 1/50,000-100,000 pregnancies representing only 0...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013439

    authors: De Nola R,Schönauer LM,Fiore MG,Loverro M,Carriero C,Di Naro E

    更新日期:2018-11-01 00:00:00

  • Procalcitonin-guided antibiotic therapy in acute exacerbation of chronic obstructive pulmonary disease: An updated meta-analysis.

    abstract:BACKGROUND:The benefit of a procalcitonin (PCT)-guided antibiotic strategy in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains uncertain. OBJECTIVES:This updated meta-analysis was performed to reevaluate the therapeutic potential of PCT-guided antibiotic therapy in AECOPD. DATA SOURCES:We ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016775

    authors: Li Z,Yuan X,Yu L,Wang B,Gao F,Ma J

    更新日期:2019-08-01 00:00:00

  • The myocardial protective effect of monosodium phosphate cardioplegia in cardiopulmonary bypass in infants with an atrial septal defect.

    abstract::This study aimed to investigate the myocardial protective effect of liquid sodium phosphocreatine cardiac arrest in extracorporeal circulation surgery treating infants with atrial septal defects.Eighty-four infants with atrial septal defects who required extracorporeal circulation surgery treatment at our hospital fro...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020934

    authors: Yang F,Wang J,Zhai B

    更新日期:2020-07-10 00:00:00

  • Prevalence of Resistant Gram-Negative Bacilli in Bloodstream Infection in Febrile Neutropenia Patients Undergoing Hematopoietic Stem Cell Transplantation: A Single Center Retrospective Cohort Study.

    abstract::Bloodstream infection (BSI) is an important cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation (HSCT). To evaluate the causative bacteria and identify risk factors for BSI associated mortality in febrile neutropenia patients undergoing HSCT, we collected the clinical and mi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001931

    authors: Wang L,Wang Y,Fan X,Tang W,Hu J

    更新日期:2015-11-01 00:00:00

  • Increased IgM-containing circulating immune complexes in patients co-infected with hepatitis C and hepatitis B.

    abstract::To assess the role of circulating immune complexes (CIC) in chronic hepatitis C virus (HCV) infection, the relative frequency of CIC was determined in 60 patients with chronic hepatitis C alone, 19 patients co-infected with hepatitis B and C, 15 asymptomatic HCV carriers, and 54 healthy controls. Levels of CIC were de...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-199505000-00003

    authors: Tsai JF,Jeng JE,Chang WY,Ho MS,Lin ZY,Tsai JH

    更新日期:1995-05-01 00:00:00

  • Long-term outcome of idiopathic pulmonary hemosiderosis in children.

    abstract::We retrospectively analyzed the long-term outcome of idiopathic pulmonary hemosiderosis (IPH) in 15 children. IPH started at a mean age of 5 years, and the mean duration of follow-up was 17.2 years (range, 10-36 yr). Four patients developed immune disorders, 3 cases of rheumatoid polyarthritis or rheumatoid polyarthri...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-200009000-00005

    authors: Le Clainche L,Le Bourgeois M,Fauroux B,Forenza N,Dommergues JP,Desbois JC,Bellon G,Derelle J,Dutau G,Marguet C,Pin I,Tillie-Leblond I,Scheinmann P,De Blic J

    更新日期:2000-09-01 00:00:00

  • Developing a simple preinterventional score to predict hospital mortality in adult venovenous extracorporeal membrane oxygenation: A pilot study.

    abstract::Despite gaining popularity, venovenous extracorporeal membrane oxygenation (VV-ECMO) remains a controversial therapy for acute respiratory failure (ARF) in adult patients due to its equivocal survival benefits. The study was aimed at identifying the preinterventional prognostic predictors of hospital mortality in adul...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004380

    authors: Cheng YT,Wu MY,Chang YS,Huang CC,Lin PJ

    更新日期:2016-07-01 00:00:00

  • Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia.

    abstract::This study aims to explore the effect of oxycodone hydrochloride injection on the immune function of patients who underwent radical resection of rectal cancer under general anesthesia.Eighty patients were enrolled and randomly divided into group A and B (n = 40, each). All patients underwent general intravenous anesth...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000007519

    authors: Cui JH,Jiang WW,Liao YJ,Wang QH,Xu M,Li Y

    更新日期:2017-08-01 00:00:00

  • Propranolol eye drops in patients with corneal neovascularization.

    abstract:RATIONALE:Studies performed in animal models of corneal neovascularization suggested the possible efficacy of a treatment with propranolol. Corneal neovascularization is one of the most feared complications of Stevens-Johnson syndrome that frequently involves ocular surface. We report the first 2 patients with severe o...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013002

    authors: Filippi L,de Libero C,Zamma Gallarati B,Fortunato P,Piozzi E

    更新日期:2018-11-01 00:00:00

  • Immunotactoid glomerulopathy.

    abstract::We present 11 patients with immunotactoid glomerulopathy, a new syndrome characterized clinically by proteinuria (11/11), microscopic hematuria (9/11) and hypertension (9/11). The patients consisted of six females and five males, aged 25 to 59 years (mean, 44.6). Proteinuria was the presenting feature and the reason f...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-198507000-00004

    authors: Korbet SM,Schwartz MM,Rosenberg BF,Sibley RK,Lewis EJ

    更新日期:1985-07-01 00:00:00

  • Preoperative Plasma Fibrinogen Level as a Significant Prognostic Factor in Patients With Localized Renal Cell Carcinoma After Surgical Treatment.

    abstract::We sought to investigate the association of preoperative fibrinogen levels with clinicopathologic outcomes after surgical treatment of nonmetastatic renal cell carcinoma. We reviewed the records of 1511 patients who had their fibrinogen levels measured preceding surgery. The associations between preoperative fibrinoge...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002626

    authors: Lee H,Lee SE,Byun SS,Kim HH,Kwak C,Hong SK

    更新日期:2016-01-01 00:00:00

  • Different treatments for acute myocardial infarction patients via outpatient clinics and emergency department.

    abstract::To investigate relevant factors and patients with acute myocardial infarction (AMI) were admitted during between weekdays and weekends period.Retrospective population-based study setting: from the 2005 population-based national health insurance underwriting database of millions of people, random sampling (National Hea...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013883

    authors: Chien CW,Wang CH,Chao ZH,Huang SK,Chen PE,Tung TH

    更新日期:2019-01-01 00:00:00

  • Bullying experience of pupils in Nigerian primary schools.

    abstract::Childhood bullying leads to life-long scars and hinders adult development. Schoolchildren involved in bullying are at risk of developing behavioural difficulties, physical health problems and suicidal ideation. This research aimed to evaluate the bullying experience of pupils in Nigerian primary schools.The study is a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022409

    authors: Umoke PCI,Umoke M,Ugwuanyi CS,Okeke CIO,Eseadi C,Onuorah AR,Ugwu GC,Obiweluozo PE,Uzodinma UE,Uwakwe RC,Uba MBI,Ebizie EN,Onyeke NG,Otu MS

    更新日期:2020-09-25 00:00:00

  • Comparison Between Ultrasound-Guided Supraclavicular and Interscalene Brachial Plexus Blocks in Patients Undergoing Arthroscopic Shoulder Surgery: A Prospective, Randomized, Parallel Study.

    abstract::Although supraclavicular brachial plexus block (SCBPB) was repopularized by the introduction of ultrasound, its usefulness in shoulder surgery has not been widely reported. The objective of this study was to compare motor and sensory blockades, the incidence of side effects, and intraoperative opioid analgesic require...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000001726

    authors: Ryu T,Kil BT,Kim JH

    更新日期:2015-10-01 00:00:00

  • A randomized trial of remifentanil for analgesia in external cephalic version for breech presentation.

    abstract:BACKGROUND:Although external cephalic version (ECV) can be effective for correcting the fetus in a cephalic presentation, it may be painful for the mother. This study aimed to evaluate the efficacy and safety of remifentanil for pain relief during ECV in China. METHODS:In all, 152 Chinese parturients with singleton br...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000005483

    authors: Liu X,Xue A

    更新日期:2016-12-01 00:00:00

  • The effect of neck-specific exercise with or without a behavioral approach on psychological factors in chronic whiplash-associated disorders: A randomized controlled trial with a 2-year follow-up.

    abstract:BACKGROUND:To investigate the effect of neck-specific exercise with (NSEB) or without (NSE) a behavioural approach and prescribed physical activity (PPA) on general pain disability and psychological factors in chronic whiplash-associated disorders (WAD), grade 2 and 3, with a 2-year follow-up. METHODS:A randomized con...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MD.0000000000004430

    authors: Overmeer T,Peterson G,Landén Ludvigsson M,Peolsson A

    更新日期:2016-08-01 00:00:00

  • Calcified peripancreatic lymph nodes in pancreatic and hepatic tuberculosis mimicking pancreatic malignancy: A case report and review of literature.

    abstract:RATIONALE:Tuberculosis remains a serious menace to the health of people. Isolated hepatic tuberculosis is rare and pancreatic tuberculosis is extremely rare. The preoperative diagnosis of pancreatic tuberculosis remains a great challenge. PATIENT CONCERNS:A 58-year-old Asian woman was referred to our hospital for eval...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000012255

    authors: Liang X,Huang X,Yang Q,He J

    更新日期:2018-09-01 00:00:00

  • Ovarian torsion in children: Development of a predictive score.

    abstract::The aim of this study was to identify clinical signs and symptoms of ovarian torsion (OT) in children and to develop a simple predictive score.A chart review of patients with acute adnexal pathologies treated at the University Children's Hospital Basel, Switzerland, between March 2006 and June 2015 was performed. Medi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008299

    authors: Bolli P,Schädelin S,Holland-Cunz S,Zimmermann P

    更新日期:2017-10-01 00:00:00