Abstract:
STUDY DESIGN:In vitro and in vivo rat tail model to assess effects of torsion on intervertebral disc biomechanics and gene expression. OBJECTIVE:Investigate effects of torsion on promoting biosynthesis and producing injury in rat caudal intervertebral discs. SUMMARY OF BACKGROUND DATA:Torsion is an important loading mode in the disc and increased torsional range of motion is associated with clinical symptoms from disc disruption. Altered elastin content is implicated in disc degeneration, but its effects on torsional loading are unknown. Although effects of compression have been studied, the effect of torsion on intervertebral disc gene expression is unknown. METHODS:In vitro biomechanical tests were performed in torsion on rat tail motion segments subjected to 4 treatments: elastase, collagenase, genipin, control. In vivo tests were performed on rats with Ilizarov-type fixators implanted to caudal motion segments with five 90 minute loading groups: 1 Hz cyclic torsion to ± 5 ± 15° and ± 30°, static torsion to + 30°, and sham. Anulus and nucleus tissues were separately analyzed using qRT-PCR for gene expression of anabolic, catabolic, and proinflammatory cytokine markers. RESULTS:In vitro tests showed decreased torsional stiffness following elastase treatment and no changes in stiffness with frequency. In vivo tests showed no significant changes in dynamic stiffness with time. Cyclic torsion upregulated elastin expression in the anulus fibrosus. Up regulation of TNF-α and IL-1β was measured at ±30°. CONCLUSION:We conclude that strong differences in the disc response to cyclic torsion and compression are apparent with torsion increasing elastin expression and compression resulting in a more substantial increase in disc metabolism in the nucleus pulposus. Results highlight the importance of elastin in torsional loading and suggest that elastin remodels in response to shearing. Torsional loading can cause injury to the disc at excessive amplitudes that are detectable biologically before they are biomechanically.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Barbir A,Godburn KE,Michalek AJ,Lai A,Monsey RD,Iatridis JCdoi
10.1097/BRS.0b013e3181d9b58bsubject
Has Abstractpub_date
2011-04-15 00:00:00pages
607-14issue
8eissn
0362-2436issn
1528-1159journal_volume
36pub_type
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