Abstract：
:Glioblastoma multiforme is a malignant, relentless brain cancer with no known cure, and standard therapies leave significant room for the development of better, more effective treatments. Immunotherapy is a promising approach to the treatment of solid tumors that directs the patient's own immune system to destroy tumor cells. The most successful immunologically based cancer therapy to date involves the passive administration of monoclonal antibodies, but significant antitumor responses have also been generated with active vaccination strategies and cell-transfer therapies. This article summarizes the important components of the immune system, discusses the specific difficulty of immunologic privilege in the central nervous system, and reviews treatment approaches that are being attempted, with an emphasis on active immunotherapy using peptide vaccines.
journal_name
Neurosurg Clin N Amjournal_title
Neurosurgery clinics of North Americaauthors
Kanaly CW,Ding D,Heimberger AB,Sampson JHdoi
10.1016/j.nec.2009.09.001subject
Has Abstractpub_date
2010-01-01 00:00:00pages
95-109issue
1eissn
1042-3680issn
1558-1349pii
S1042-3680(09)00084-9journal_volume
21pub_type
杂志文章,评审abstract：:The recognition of a number of uncommon tumors of the skull base is now relatively simple because of three-dimensional computed tomography and magnetic resonance imaging with enhancement. The radiographic classification of these tumors is reviewed, and their treatment is discussed. Although the basic approach to these...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:Advanced age is associated with a less favorable outcome following aneurysmal SAH, in large part, because of associated medical conditions. Nevertheless, available data suggest that elderly patients often benefit from aggressive treatment and that a reasonable outcome at a reasonable cost can be expected in selected p...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1998-07-01 00:00:00
abstract：:Hemostasis is a cell-based process that is regulated in a tissue-specific manner by the differential expression of procoagulant and anticoagulant factors on endothelial cells from different sites throughout the vasculature. The central nervous system, in particular, exhibits unique mechanisms of hemostatic regulation ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2018.05.001
更新日期：2018-10-01 00:00:00
abstract：:Spinal laser interstitial thermal therapy (LITT) appears to be a promising novel modality for treatment of epidural metastatic spine disease in patients who are poor candidates for larger-scale oncologic spinal surgery and can act synergetically with spinal stereotactic radiosurgery to maximize local control and palli...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2017.05.006
更新日期：2017-10-01 00:00:00
abstract：:Autopsy studies suggest that skull base metastases are likely underrecognized in patients with cancer. Patients frequently present with one or a combination of skull base clinical syndromes that manifest as pain or cranial neuropathy. Once a skull base metastasis is suspected, establishing a histologic diagnosis, dedi...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2020.06.013
更新日期：2020-10-01 00:00:00
abstract：:Although craniofacial problems are commonly detected during the neonatal period, only a selected subgroup of lesions require early intervention. Such lesions are characterized either by their potential for causing early neurologic impairment, infection, or other severe sequelae if treatment is delayed or by the fact t...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：:Infections of the CNS have a high mortality, and rapid laboratory diagnosis and adequate antimicrobial therapy are critically important for their management. New techniques assist the clinical microbiology laboratory to isolate and identify micro-organisms more rapidly and accurately than with the use of classic proce...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：:Cerebral vasospasm is a cause of significant morbidity and mortality in patients with subarachnoid hemorrhage (SAH). Most cases of vasospasm can be managed medically. Medical strategies for treatment include hemodynamic augmentation to improve cerebral perfusion pressure and medical therapy to prevent or reduce cerebr...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2009.10.007
更新日期：2010-04-01 00:00:00
abstract：:Although timing for surgical intervention after spinal cord injury remains controversial, there is accumulating evidence suggesting that early surgery may improve neurologic outcomes, particularly with incomplete spinal cord injury, and may reduce non-neurologic complications and health care resource utilization. More...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2016.08.005
更新日期：2017-01-01 00:00:00
abstract：:This article reviews the authors' experience with image-guided surgery for brain metastases and discusses specifically the impact of the frameless viewing wand system on standard craniotomy techniques for this disorder. Topics discussed include patient selection, interactive image-guided neurosurgical resection of bra...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:There seems to be no doubt that periarterial clot causes vasospasm and that vasospasm is a significant cause of delayed ischemic neurologic deficits and infarcts. It is to be hoped that a way can be found to remove such clots effectively and rapidly before they do their deadly damage. ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1990-04-01 00:00:00
abstract：:Pancoast tumors (superior sulcus tumors or apical lung tumors) typically invade structures at the thoracic outlet, including the inferior elements of the brachial plexus (C8, T1 nerve roots and lower trunk). Historically, these tumors are rapidly fatal, but newer treatment with induction chemotherapy and radiotherapy,...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章
doi：10.1016/j.nec.2008.07.002
更新日期：2008-10-01 00:00:00
abstract：:Satisfactory therapy for an avulsion injury of the brachial plexus has yet to be described. Dorsal root entry zone lesions will usually mitigate the searing pain which is so disabling in some of these patients. Neurotization procedures are effective in restoring limited function to these patients. The most useful isol...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Endovascular embolization is a frequently used adjunct to operative resection of meningiomas. Embolization may decrease intraoperative blood loss, operative time, and surgical difficulty associated with resection. The specific clinical applications of this treatment have not been defined clearly. Procedural indication...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2015.11.005
更新日期：2016-04-01 00:00:00
abstract：:The anatomy of the peripheral nervous system is presented, with special emphasis on the connective tissue sheaths and their relationship to the nerves' blood supply. The microanatomy of nerve fibers is also presented, with a focus on pathologic changes caused by compression and ischemic injuries. The article highlight...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:Endovascular management has become the treatment of choice for carotid-cavernous fistulas regardless of the fistula type. The endovascular method offers numerous options that render it capable of treating each fistula type by choosing an adequate technique. This advantage along with the advancement in the field has le...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2014.04.011
更新日期：2014-07-01 00:00:00
abstract：:Percutaneous vertebroplasty and kyphoplasty provide minimally invasive options for the management of osteoporotic and osteolytic vertebral compression fractures. These techniques provide substantial pain relief and support without requiring long periods of recumbency, and have an acceptable complication rate. Vertebra...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2006.06.005
更新日期：2006-10-01 00:00:00
abstract：:Glioblastoma (GBM) is infiltrative neoplasm with limited treatment options and poor overall survival. Stereotactic radiosurgery (SRS) allows spatially precise and conformal delivery of high doses of radiation. Salvage SRS for locally recurrent GBM was shown to improve patient survival and have more favorable safety pr...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2020.08.007
更新日期：2021-01-01 00:00:00
abstract：:Clival, petroclival, and foramen magnum meningiomas are challenging lesions to manage independently of the selected surgical approach. The expanded endoscopic endonasal approach (EEA) provided a safe alternative on the armamentarium of skull base approaches. There is a paucity of literature regarding endoscopic manage...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2015.03.006
更新日期：2015-07-01 00:00:00
abstract：:The middle fossa approach is useful for the removal of small acoustic tumors when hearing preservation is possible. This approach provides complete exposure of the contents of the internal auditory canal and positive facial nerve identification. Because access to the posterior fossa is limited, the middle fossa approa...
journal_title：Neurosurgery clinics of North America
pub_type： 传,古典文章,历史文章,杂志文章
doi：10.1016/j.nec.2008.02.009
更新日期：2008-04-01 00:00:00
abstract：:Spinal dural arteriovenous fistulas (AVFs) are the most common spinal vascular malformation. The spinal dural AVF is a disease of adults, primarily men, that is a cause of subacute progressive lower extremity myelopathy. The challenge for the optimum management of these patients is in making an accurate, early diagnos...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:Degenerative lumbar spondylolisthesis is one of the most common causes of low back pain and is defined as displacement of one vertebra over subjacent vertebra, associated with degenerative changes, without an associated disruption or defect in the vertebral ring. Undersetanding natural history of degenerative spondylo...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2019.02.003
更新日期：2019-07-01 00:00:00
abstract：:Common intracranial complications following head injury are meningitis, usually associated with a basilar skull fracture or open-depressed skull fracture; delayed hematoma; hydrocephalus; and vascular injuries. Prophylactic antibiotics are not recommended for the management of basilar skull fractures. The best means o...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1991-04-01 00:00:00
abstract：:Cancer-associated facial pain can be caused by a variety of pathologic conditions. Here the authors describe the symptoms and incidence of facial pain secondary to three separate anatomic subcategories of cancer. The authors subsequently discuss the effectiveness and drawbacks of the most common methods of treatment. ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2016.02.009
更新日期：2016-07-01 00:00:00
abstract：:The major unifying concept of the effect of trauma on the central nervous system is the application of force to the brain. The mode of delivery of energy and its dissipation result in the varying pathologic manifestations of hemorrhage, contusions, or tears. Topics discussed in this article include inner cerebral trau...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:Primary sarcomas are rare in the spine. Common primary sarcomas include osteosarcoma, Ewing's sarcoma, chondrosarcomas, and retroperitoneal soft-tissue sarcomas. These tumors tend to occur in adolescents and young adults. Surgery remains the mainstay of treatment, although the anatomy of spine and spinal cord often li...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nec.2007.10.001
更新日期：2008-01-01 00:00:00
abstract：:Child abuse is a widespread phenomenon which is increasingly recognized in our culture. In this chapter, the epidemiology, clinical presentation, and commonly associated injuries are reviewed. The typical presentation and clinical assessment of inflicted head injury is also described. ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s1042-3680(02)00002-5
更新日期：2002-04-01 00:00:00
abstract：:There are two hypotheses on how chronic subdural hematoma causes hemiparesis and other focal neurologic symptoms without, in most cases, leaving permanent neurologic deficits. One hypothesis is that the reduced regional cerebral blood flow (rCBF) caused by either compression or distortion of the local or remote brain ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：:In this era of modern neurosurgery, we are able to provide adequate amelioration of disabling symptoms for the small subset of patients who have conditions that may make them unacceptable candidates for invasive stereotactic neurosurgical intervention. Gamma Knife radiosurgical thalamotomy is an effective and useful a...
journal_title：Neurosurgery clinics of North America
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1999-04-01 00:00:00
abstract：:This article provides basic pharmacologic and behavioral principles and facts to simplify drug therapy for low back pain. It outlines basic protocols for symptom control while definitive treatments are beginning or healing occurs. ...
journal_title：Neurosurgery clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1991-10-01 00:00:00
