Abstract:
:Hematologic malignancies are predominantly treated with chemotherapy or a combination of chemotherapy with monoclonal antibodies. Current treatment regimens often are not satisfactory due to severe side effects and a substantial proportion of relapsed patients. This has prompted the development of better tolerated and more efficacious immunotherapeutic strategies for the treatment of lymphoma and leukemia. With blinatumomab (MT103) a first antibody, which can potentially engage all cytotoxic T cells of a patient for tumor cell lysis, is now available for clinical evaluation. Blinatumomab is a single-chain bispecific antibody construct with specificity for CD19 and CD3 belonging to the class of bispecific T cell engager. Here, we review the current progress in development of blinatumomab for treatment of patients with CD19-expressing hematological malignancies.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Nagorsen D,Bargou R,Ruttinger D,Kufer P,Baeuerle PA,Zugmaier Gdoi
10.1080/10428190902943077subject
Has Abstractpub_date
2009-06-01 00:00:00pages
886-91issue
6eissn
1042-8194issn
1029-2403pii
911421011journal_volume
50pub_type
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