Differences Between Long- and Short-Term Survivors with Lymphoma Type of Adult T-Cell Leukemia.

Abstract:

:The clinical features at time of diagnosis of long-term survivors with lymphoma type of adult T-cell leukemia (ATL) were compared with those of short-term survivors. We had 51 Japanese patients with lymphoma type of ATL from 1981 to 1989 who had human T-cell leukemia virus type I (HTLV-I) antibody and monoclonal integration of HTLV-,I proviral DNA in the malignant cells. Of the 51 patients, 7 survived for more than 3 years, and they were classified as long-term survivors. Twenty-four patients died within 1 year and they were classified as short-term survivors. Differences between these two groups were investigated with the clinical findings recorded at the time of diagnosis. Findings that proved significant were serum lactate dehydrogenase (LDH) levels, calcium, total protein levels and the presence of B symptoms. Patients with lymphoma type of ATL are expected to be long-term survivors if they have no hypercalcemia or B symptoms with only mildly elevated serum LDH and total protein levels.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Shimamot Y,Suga K,Igarashi H,Nishimura J,Nawata H,Yamaguchi M

doi

10.3109/10428199009106465

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

301-5

issue

5

eissn

1042-8194

issn

1029-2403

journal_volume

2

pub_type

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