Abstract:
:Sensitivities of a wildlife species, deer mice, to oxidants were evaluated. A single dose (1589 mg/kg body weight by intraperitoneal injection) of carbon tetrachloride, a typical hepatotoxicant, caused changes in GCL activity and GSH content in multiple organs of deer mice. Hepatic GCL activity and GSH content were depleted substantially (P<0.01), renal GCL activity increased (P<0.05). Blood, brain and heart GCL activities increased (P<0.05), whereas GSH contents decreased significantly. Deer mice were exposed to Pb, or Pb together with Cu and Zn via drinking water for 4 weeks. GCL activities were not significantly affected by treatments. GSH contents were increased significantly by Pb alone, Pb with medium and high concentrations of Cu and Zn. Effects of multi-metal-contaminated soil were investigated via lactational, juvenile and lifelong exposure to feed supplemented with soils. Metal-contaminated soils did not lead to significant effects in pups via lactation, 50-day exposure altered GSH content marginally, while 100-day exposure resulted in marked GCL activity depletion. After 100-day exposure, GCL activities of the medium soil-, high soil- and Pb-treated deer mice were only 53%, 40% and 46% of the control, respectively (P<0.0001).
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Wu H,McBride TJ,Isanhart JP,Cox SB,Hooper MJdoi
10.1016/j.ecoenv.2009.02.008subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1572-8issue
5eissn
0147-6513issn
1090-2414pii
S0147-6513(09)00036-0journal_volume
72pub_type
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
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journal_title:Ecotoxicology and environmental safety
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