当前位置： SCI文献检索 > JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA期刊下所有文献 > Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery.

Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery.

Abstract：

OBJECTIVE:This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery. DESIGN:A prospective, randomized, double-blind, placebo-controlled study. SETTING:The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University. PARTICIPANTS:One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled into the study. Eight patients were withdrawn, and 100 patients were divided into 2 groups. INTERVENTIONS:Fifty patients received tranexamic acid (bolus 1 g before skin incision and followed by maintenance dose of 400 mg/h during surgery), and 50 patients received saline. MEASUREMENT AND MAIN RESULTS:Hematologic parameters, volume of blood loss, blood transfusion, and other clinical data were recorded throughout the perioperative period. Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). Patients in the tranexamic acid group received significantly less allogeneic blood (8 v 31 units). CONCLUSION:Bleeding and hemorrhagic complications and the consequent need for allogeneic transfusion are still major problems after off-pump coronary artery bypass surgery. Tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products.

journal_name

J Cardiothorac Vasc Anesth

journal_title

Journal of cardiothoracic and vascular anesthesia

authors

Taghaddomi RJ,Mirzaee A,Attar AS,Shirdel A

doi

10.1053/j.jvca.2008.09.018

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

312-5

issue

3

eissn

1053-0770

issn

1532-8422

pii

S1053-0770(08)00299-1

journal_volume

23

pub_type

杂志文章,随机对照试验

相关文献

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA文献大全
  • Markers of splanchnic perfusion and intestinal translocation of endotoxins during cardiopulmonary bypass: effects of dopamine and milrinone.

    abstract：OBJECTIVES:To investigate markers of splanchnic perfusion and the extent of endotoxemia during cardiopulmonary bypass (CPB) and to compare the effects of dopamine and milrinone on both splanchnic perfusion and endotoxemia. DESIGN:Prospective, randomized, blinded study. SETTING:University teaching hospital. PARTICIPA...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1053-0770(99)90266-5

    authors： McNicol L,Andersen LW,Liu G,Doolan L,Baek L

    更新日期：1999-06-01 00:00:00

  • Does high-dose methylprednisolone in aprotinin-treated patients attenuate the systemic inflammatory response during coronary artery bypass grafting procedures?

    abstract：OBJECTIVE:To discover the possible effects of methylprednisolone on the systemic inflammatory response during aprotinin treatment. DESIGN:Randomized, double-blinded study. SETTING:University-affiliated heart center. PARTICIPANTS:Fifty-two patients scheduled for elective coronary artery bypass grafting. INTERVENTION...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1053-0770(99)90081-2

    authors： Tassani P,Richter JA,Barankay A,Braun SL,Haehnel C,Spaeth P,Schad H,Meisner H

    更新日期：1999-04-01 00:00:00

  • Meta-Analysis of the Outcome After Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation in Adult Patients.

    abstract：OBJECTIVE:This study was planned to pool existing data on outcome and to evaluate the efficacy of postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) in adult patients. DESIGN:Systematic review of the literature and meta-analysis. SETTING:Multi-institutional study. PARTICIPANTS:Adult patients w...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章,meta分析,评审

    doi：10.1053/j.jvca.2017.08.048

    authors： Biancari F,Perrotti A,Dalén M,Guerrieri M,Fiore A,Reichart D,Dell'Aquila AM,Gatti G,Ala-Kokko T,Kinnunen EM,Tauriainen T,Chocron S,Airaksinen JKE,Ruggieri VG,Brascia D

    更新日期：2018-06-01 00:00:00

  • Current use of the pulmonary artery catheter in cardiac surgery: a survey study.

    abstract：OBJECTIVE:Because of its invasive nature, debated effect on patient outcome, and the development of alternative hemodynamic monitoring technologies, the intraoperative use of the pulmonary artery catheter (PAC) has significantly decreased. The authors conducted a survey of the members of the Society of Cardiovascular A...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2014.07.016

    authors： Judge O,Ji F,Fleming N,Liu H

    更新日期：2015-02-01 00:00:00

  • Assessment of the tricuspid valve: a comparison of four transesophageal echocardiographic windows.

    abstract：OBJECTIVE:Tricuspid valve annular dilation is associated with persistent tricuspid valve regurgitation (TR) after cardiac surgery. The purpose of this study is to compare assessment of the tricuspid valve annulus from 4 different echocardiographic windows. DESIGN:Prospective study. SETTING:Single tertiary care hospit...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 临床试验,杂志文章

    doi：10.1053/j.jvca.2004.08.008

    authors： Maslow AD,Schwartz C,Singh AK

    更新日期：2004-12-01 00:00:00

  • A beta-blocker, not magnesium, is effective prophylaxis for atrial tachyarrhythmias after coronary artery bypass graft surgery.

    abstract：OBJECTIVE:To evaluate magnesium as a sole or adjuvant agent with currently used prophylactic drugs in suppressing postoperative atrial tachyarrhythmias (POAT) after coronary artery bypass graft (CABG) surgery. DESIGN:Single-center prospective, randomized clinical trial. SETTING:University hospital. PARTICIPANTS:Pati...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1053/jcan.2001.21959

    authors： Bert AA,Reinert SE,Singh AK

    更新日期：2001-04-01 00:00:00

  • Methylene blue does not neutralize heparin after cardiopulmonary bypass.

    abstract：OBJECTIVE:It was hypothesized that methylene blue could neutralize heparin in patients after cardiopulmonary bypass and become an alternative to protamine. DESIGN:This was a prospective unblinded study with patients serving as their own controls. SETTING PARTICIPANTS: A single, large university hospital. This study wa...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1016/s1053-0770(05)80007-2

    authors： Metz S,Horrow JC,Goel IP,Kuretu ML,Bellwoar C

    更新日期：1996-06-01 00:00:00

  • Propofol-based versus fentanyl-isoflurane-based anesthesia for cardiac surgery.

    abstract：OBJECTIVE:To evaluate drug costs, time of mechanical ventilation, complications, and hospital length of stay comparing propofol-based with fentanyl-isoflurane-based anesthesia. DESIGN:A prospective, randomized study. SETTING:A university-affiliated, tertiary care community hospital. PARTICIPANTS:Seventy patients und...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1053-0770(98)90328-7

    authors： Engoren MC,Kraras C,Garzia F

    更新日期：1998-04-01 00:00:00

  • Efficacy of Bilateral Erector Spinae Plane Block in Management of Acute Postoperative Surgical Pain After Pediatric Cardiac Surgeries Through a Midline Sternotomy.

    abstract：OBJECTIVE:Regional analgesia continues to evolve with the introduction of ultrasound-guided fascial plane blocks. Erector spinae plane block (ESPB) is a novel technique gaining recent acceptability as a perioperative modality of analgesia in various thoracic and abdominal surgeries. However, literature on the use of ES...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2019.08.009

    authors： Kaushal B,Chauhan S,Magoon R,Krishna NS,Saini K,Bhoi D,Bisoi AK

    更新日期：2020-04-01 00:00:00

  • Persistent kidney injury at hospital discharge after cardiac surgery with cardiopulmonary bypass in patients with normal preoperative serum creatinine and normal estimated glomerular filtration rate.

    abstract：OBJECTIVE:Acute kidney injury is a serious complication after cardiac surgery. Although it resolves in most cases, a significant portion of patients persistently have raised creatinine values at hospital discharge. These patients are at greater risk for developing chronic kidney disease and mortality. Therefore, the pr...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2014.05.007

    authors： Ge Ng RR,Huey Chew ST,Liu W,Kah Ti L

    更新日期：2014-12-01 00:00:00

  • A Rare Cause of a Left Atrial Mass.

    abstract：:Intramyocardial hematomas are a rare complication of myocardial infarctions. Normally restricted to the left ventricle, in certain scenarios, such as after a percutaneous coronary intervention, intramyocardial hematomas also can occur in the left atrium. Herein, the case of a 74-year-old man who presented to the autho...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2020.06.053

    authors： Patoli D,Alghanem H,Tung A

    更新日期：2020-10-01 00:00:00

  • Methicillin-resistant Staphylococcus species in a cardiac surgical intensive care unit: a 5-year experience.

    abstract：OBJECTIVES:Methicillin-resistant Staphylococcus is a growing problem in intensive care units (ICUs). The aim of this study was to describe the epidemiology of methicillin-resistant Staphylococcus isolates in a cardiac surgical ICU over a 5-year period and to determine the risk factors and outcome of this condition. ME...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2004.12.002

    authors： Zangrillo A,Landoni G,Fumagalli L,Bove T,Bellotti F,Sottocorna O,Roberti A,Marino G

    更新日期：2006-02-01 00:00:00

  • Resolved: A pulmonary artery catheter should be used in the management of the critically ill patient. Con.

    abstract：:Complications associated with pulmonary artery catheters (PACs) include interpretation errors, insertion problems, sepsis, thrombosis, and dysrhythmias. Alternatives to the use of PACs include the central venous pressure catheter, measurement of cardiac output by thoracic electrical bioimpedance, gastric tonometry and...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 评论,杂志文章,评审

    doi：

    authors： Becker K Jr

    更新日期：1998-04-01 00:00:00

  • Tricuspid Regurgitation in Congestive Heart Failure: Management Strategies and Analysis of Outcomes.

    abstract：:Tricuspid regurgitation is a notable aspect of congestive heart failure and is linked with worse outcomes if untreated. Functional tricuspid regurgitation commonly is seen in patients with heart failure, particularly in patients presenting for surgical management, such as those for mechanical cardiac assist device imp...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章,评审

    doi：10.1053/j.jvca.2020.06.022

    authors： Ramsdell GC,Nelson JA,Pislaru SV,Ramakrishna H

    更新日期：2020-06-12 00:00:00

  • Cardiac output calculation and three-dimensional echocardiography.

    abstract：OBJECTIVE:To compare the determination of stroke volume (SV) and cardiac output (CO) using 2-dimensional (2D) versus 3-dimensional (3D) transesophageal echocardiography (TEE). DESIGN:Prospective observational study. SETTING:Tertiary care university hospital. PARTICIPANTS:35 patients without structural valve abnormal...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2013.11.005

    authors： Montealegre-Gallegos M,Mahmood F,Owais K,Hess P,Jainandunsing JS,Matyal R

    更新日期：2014-06-01 00:00:00

  • The impact of intra-aortic balloon pumping on cardiac output determination by pulmonary arterial and transpulmonary thermodilution in pigs.

    abstract：OBJECTIVE:The aim of this study was to evaluate the impact of intra-aortic balloon pumping (IABP) on the comparison of simultaneous measurements of cardiac output via pulmonary arterial and transpulmonary thermodilution (PiCCO; Pulsion Medical Systems, Munich, Germany). DESIGN:Prospective. SETTINGS:University researc...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2005.11.020

    authors： Janda M,Scheeren TW,Bajorat J,Westphal B,Vagts DA,Pohl B,Popescu C,Hofmockel R

    更新日期：2006-06-01 00:00:00

  • Three-dimensional reconstructions of normal and aneurysmatic left ventricles in vivo using transesophageal echocardiography.

    abstract：OBJECTIVE:To perform three-dimensional surface reconstructions to provide spatial delineations of a normal and an aneurysmatic left ventricle, using transesophageal echocardiography. DESIGN:Prospective study. SETTING:University hospital. PARTICIPANTS:Eight patients in cardiogenic shock admitted to the intensive care...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1053-0770(00)90006-5

    authors： Sivarajan M,Klues H,Krebs W,Steinert S,Franke A,Janssens U,Hanrath P

    更新日期：2000-04-01 00:00:00

  • Dexmedetomidine Versus Propofol Sedation Improves Sublingual Microcirculation After Cardiac Surgery: A Randomized Controlled Trial.

    abstract：OBJECTIVES:To compare the effects of dexmedetomidine and propofol on sublingual microcirculation in patients after cardiac surgery. DESIGN:A prospective, randomized, single-blind study. SETTING:University hospital. PARTICIPANTS:Adult patients undergoing elective valve surgery with cardiopulmonary bypass. INTERVENTI...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章,随机对照试验

    doi：10.1053/j.jvca.2016.05.038

    authors： Liu X,Zhang K,Wang W,Xie G,Cheng B,Wang Y,Hu Y,Fang X

    更新日期：2016-12-01 00:00:00

  • Atrial fibrillation after cardiac surgery: incidence, risk factors, and economic burden.

    abstract：OBJECTIVE:To evaluate the incidence of postoperative atrial fibrillation (POAF), the predisposing factors, the results of treatment before discharge, and the impact on duration and costs of hospitalization. DESIGN:A prospective observational study. METHODS:Patients who underwent cardiac surgery from January 1, 2007 t...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2010.03.009

    authors： Rostagno C,La Meir M,Gelsomino S,Ghilli L,Rossi A,Carone E,Braconi L,Rosso G,Puggelli F,Mattesini A,Stefàno PL,Padeletti L,Maessen J,Gensini GF

    更新日期：2010-12-01 00:00:00

  • Transesophageal Echocardiographic Measurement of Cardiac Index by the Prosthetic Mitral Valve Method Is Not Similar to the Continuous Thermodilution Method Via a Pulmonary Artery Catheter.

    abstract：OBJECTIVE:To compare the agreement of cardiac index measurements between transesophageal echocardiography across the prosthetic mitral valve and the continuous thermodilution method through a pulmonary artery catheter (PAC-TD) in patients undergoing double-valve replacement. DESIGN:Observational prospective study. SE...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2015.10.022

    authors： Shi H,Wang Z,Wei H,Ge Y,Chen X

    更新日期：2016-04-01 00:00:00

  • Brain Oxygen Supply Parameters in the Risk Assessment of Cerebral Complications During Carotid Endarterectomy.

    abstract：OBJECTIVE:To determine whether preoperative regional cerebral oxygen saturation (rSO2) and the decrease in rSO2 during carotid clamping were predictive of the risk for neurologic complications in carotid endarterectomy and to determine the cutoff values of the studied parameters. DESIGN:Cohort, prospective, nonrandomi...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 临床试验,杂志文章

    doi：10.1053/j.jvca.2016.10.017

    authors： Kamenskaya OV,Loginova IY,Lomivorotov VV

    更新日期：2017-06-01 00:00:00

  • Echocardiographic Assessment of Left Ventricular Assist Device Outflow Velocity During Percutaneous Decommissioning.

    abstract：:Left ventricular assist devices (LVADs) have been used as an effective therapeutic option in patients with advanced heart failure, either as a bridge to transplantation or, in some patients, as a bridge to recovery. LVAD withdrawal with ventricular recovery represents the optimal outcome for patients previously implan...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2020.12.043

    authors： Liu X,Kimmelstiel C,Couper GS,Brovman EY

    更新日期：2021-01-05 00:00:00

  • Changes in intensive care unit performance measures associated with opening a dedicated thoracic surgical progressive care unit.

    abstract：OBJECTIVES:To determine the effect of the introduction of a specialty-specific progressive care unit (PCU) on the intensive care unit (ICU) to which relatively low-acuity patients had previously been admitted. DESIGN:Retrospective cohort study. SETTING:The thoracic (noncardiac) surgical ICU of a tertiary referral ins...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2007.12.015

    authors： Keegan MT,Brown DR,Thieke MP,Afessa B

    更新日期：2008-06-01 00:00:00

  • Feasibility of Anesthesia Maintenance With Sevoflurane During Cardiopulmonary Bypass: A Pilot Pharmacokinetics Study.

    abstract：OBJECTIVE:Adequate maintenance of hypnosis during anesthesia throughout surgery using sevoflurane alone was investigated. In addition, sevoflurane pharmacokinetics during cardiopulmonary bypass were analyzed. DESIGN:This was a pilot pharmacokinetic study. SETTING:Tertiary care university hospital. PARTICIPANTS:The s...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2016.12.018

    authors： Meroni R,Gianni S,Guarnieri M,Saglietti F,Gemma M,Zangrillo A,Bignami E

    更新日期：2017-08-01 00:00:00

  • Outcomes of Infant Cardiac Surgery for Congenital Heart Disease Concomitant With Persistent Pneumonia: A Retrospective Cohort Study.

    abstract：OBJECTIVES:There is still controversy about whether an infant should have cardiac surgery concomitant with ongoing persistent pneumonia. This study analyzes the outcome of surgical treatment for infants with left-to-right shunt congenital heart disease accompanied with persistent pneumonia and discusses the perioperati...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2018.05.039

    authors： Luo H,Qin G,Wang L,Ye Z,Pan Y,Huang L,Luo W,Guo Q,Peng Y,Wang E

    更新日期：2019-02-01 00:00:00

  • Determinants of postoperative hypothermia after normothermic cardiopulmonary bypass.

    abstract：:Inadvertent postoperative hypothermia in the cardiac surgical patient can have various adverse physiologic effects. Previous studies have investigated the relationship of patient, surgical, and anesthetic factors with postoperative hypothermia in patients undergoing noncardiac surgery. This study was designed to asses...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1016/s1053-0770(05)80186-7

    authors： Baker J,Baker AJ,Mazer CD

    更新日期：1995-04-01 00:00:00

  • Enalaprilat decreases plasma endothelin and atrial natriuretic peptide levels and preload in patients with left ventricular dysfunction after cardiac surgery.

    abstract：OBJECTIVE:To study the acute effects of angiotensin-converting enzyme inhibition by intravenous enalaprilat infusion in patients with left ventricular dysfunction after cardiac surgery. DESIGN:Prospective, consecutive sample, before-after trial. SETTING:Surgical intensive care unit in a tertiary care university hospi...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1016/s1053-0770(97)90009-4

    authors： Tohmo H,Karanko M,Klossner J,Scheinin M,Viinamäki O,Neuvonen P,Ruskoaho H

    更新日期：1997-08-01 00:00:00

  • Supraglottic Airway Use for Transfemoral-Transcatheter Aortic Valve Replacement.

    abstract：OBJECTIVE:Examine outcome differences in patients managed either with a supraglottic airway or an endotracheal tube for general anesthesia during transcatheter aortic valve replacement. The authors hypothesized that patients managed with a supraglottic airway would have shorter post-anesthesia care unit and hospital st...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2020.04.059

    authors： Azad SS,Cobey FC,Price LL,Schumann R,Shapeton AD

    更新日期：2020-12-01 00:00:00

  • Incidence and significance of abnormal hepatic venous Doppler flow velocities before cardiac surgery.

    abstract：OBJECTIVE:The purpose of this study was to determine the incidence and significance of abnormal hepatic Doppler venous flow velocities as signs of an abnormal right ventricular filling pattern before cardiac surgery. DESIGN:Retrospective and prospective validation study. SETTING:Tertiary care hospital. PARTICIPANTS:...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 杂志文章

    doi：10.1053/j.jvca.2004.11.052

    authors： Carricart M,Denault AY,Couture P,Limoges P,Babin D,Levesque S,Fortier A,Pellerin M,Tardif JC,Buithieu J

    更新日期：2005-12-01 00:00:00

  • Hemodynamic effects and onset time of increasing doses of vecuronium in patients undergoing myocardial revascularization.

    abstract：:Study objectives were (1) to compare the hemodynamic effects of increasing doses of vecuronium, given as a bolus during induction of anesthesia using high-dose fentanyl, in patients undergoing myocardial revascularization; and (2) to determine whether increasing the dose of vecuronium would decrease the onset time to ...

    journal_title：Journal of cardiothoracic and vascular anesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/1053-0770(91)90008-h

    authors： Chen BB,Nyhan DP,Blanck TJ

    更新日期：1991-12-01 00:00:00