Abstract:
OBJECTIVE:The aim of this study was to estimate the effects of age and comorbidity on the choice of treatment modalities and prognosis for patients with cervical cancer. METHODS:All patients with cervical cancer newly diagnosed between 1995 and 2004 (n=775) were selected from the population-based Eindhoven Cancer Registry. Time trends in treatment modalities and differences in treatment between older and younger patients, and those with and without comorbidity were evaluated. RESULTS:Older patients with FIGO Stages IB-IIA, elderly and those with comorbidity underwent less surgery. In multivariate survival analysis, age had independent prognostic value. For patients with FIGO Stages IB2, IIB-IVA, age affected the choice of chemoradiation significantly. According to multivariate survival analysis, comorbidity and FIGO stage were independent prognostic factors. CONCLUSION:Older patients with cervical cancer and those with comorbidity were treated less aggressively. Because of the ever-increasing role of comorbidity in clinical decision-making for increasingly older patients in the near future, development of age-specific guidelines incorporating levels and management of specific comorbidity seems warranted.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
van der Aa MA,Siesling S,Kruitwagen RF,Lybeert ML,Coebergh JW,Janssen-Heijnen MLsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
493-8issue
5eissn
0392-2936issn
2709-0086journal_volume
29pub_type
杂志文章abstract::Fertility sparing surgery might be a benefit for young patients with early-stage cervical cancer. The authors herein describe a case of adenocarcinoma of cervix Stage IA2 treated with laparoscopic radical trachelectomy (LRT) with round ligament and uterine artery preservation. ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
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journal_title:European journal of gynaecological oncology
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abstract::The Authors, on the basis of the literature and their own experience, propose a diagnostic schedule for detection of breast disease based on integrated thermography, diaphanoscopy, echography and mammography. ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
abstract::Terminology of HPV infections of the uterine cervix and vagina is somewhat confusing, with various terms having different meanings to different authors. This prompted us to revise the current terminology and propose a "tissue-based" classification of HPV infections of the cervix and vagina (mucosal HPV infections), wh...
journal_title:European journal of gynaecological oncology
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更新日期:2010-01-01 00:00:00
abstract::Ductal carcinoma in situ (DCIS) represents a biologically and morphologically heterogeneous disease. It is characterized by a proliferation of presumably epithelial malignant cells confined within the lumens of the mammary ducts, without evidence of invasion beyond the basement membrane into the adjacent breast stroma...
journal_title:European journal of gynaecological oncology
pub_type: 历史文章,杂志文章
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更新日期:2006-01-01 00:00:00
abstract::The Authors studied the presence of some markers in different gynaecological tumours, by radioimmunoassay. Beta-HCG, 1-alfa-FP, CA 125, GICA and TPA were assayed in 76 patients. Eight of the patients were affected by CIN III, 38 presented a cervical carcinoma (10 at stage I, 14 at stage II, 10 at stage III, 4 at stage...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::402 radical hysterectomies (17 ultraradical) were performed with lymphadenectomy. Positive metastatic nodes (N+) rate was 23.6% with an arithmetic mean of 22 excised lymph nodes. Single N+ belonged mostly to the obturatory group, double N+ to obturatory and external iliac groups, while multiple N+ (24 cases) had no pa...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:The aim of our study was to detect any rise in serum levels of CA-125 after hysterosalpingography (HSG) as a result of irritation of the peritoneum. STUDY DESIGN:Serum levels of CA-125 were assessed before HSG and at the 2nd and 6th hours after HSG in 32 infertile patients who were admitted to our clinic fro...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::This paper reports an investigation of the mechanism involved in the response of endometrial adenocarcinoma to MPA. The following protocol was used for a period of 8 years: 1 g/day MPA per os for 30 days and 60 days after surgery, following by 500 mg/day for 1 year. Adenocarcinoma glycolytic activity, G-6-P cycle, pol...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::High-risk human papillomaviruses (HPV) play a vital role in the development of precancerous changes or cancer in the uterine cervix. Prophylactic vaccination has proven to be an effective measure to reduce the incidence of precancerous changes in the uterine cervix and thereby also of cervical cancer. A population inv...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Despite its infrequency, pregnancy associated breast cancer implies multiple therapeutic dilemmas. Our patient, a 32-year-old Caucasian, gravida 2, para 2, was diagnosed with cancer of the left breast in the 19th week of gestation. Shortly after she underwent quadrantectomy plus axillary lymph node dissection. Chemoth...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Six patients with vulvar malignant melanoma are reported. They accounted for 5.2% of all females with vulvar malignancies diagnosed in the south of Israel between 1961 and 1997. Age ranged from 25 to 66 years. Presenting symptoms were pruritus, bleeding and ulcer. Lesion originated in the labia minora in four patients...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:PURPOSE OF INVESTIGATION:To determine the effect of imatinib on progression-free survival in patients with epithelial ovarian cancer in second or greater complete clinical remission (CCR). METHODS:35 patients were enrolled between 10/2002 and 1/2005. Eligible patients received imatinib at 400 mg daily orally. RESULTS...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:PURPOSE OF INVESTIGATION:To document the relationship between smoking and HPV infection, and the risk of developing preinvasive lesions and cervical carcinoma. MATERIALS AND METHODS:Prospective, cross-sectional descriptive study. A total of 1,007 patients were recruited among women seen at the cervical pathology clini...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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更新日期:2017-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Renal cell carcinoma is seen most frequently after childbearing years, but occasionally is diagnosed in pregnancy. The pregnancy demands special considerations in terms of the diagnostic evaluation and management. A case of a patient with renal cell carcinoma diagnosed in the first trimester of pregnancy, which sudden...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::The prognostic factors and their intercorrelation in 47 patients with IB endometrial cancer are presented. The data reveal the particular behaviour of the lymphatic involvement: five patients (10.6%) showed metastases to pelvic lymph nodes and six patients (12.8%) had paraaortic node metastases; altogether two women (...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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更新日期:2007-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:2014-01-01 00:00:00
abstract::A retrospective four-year review showed that six morbidly obese (> or = 40 kg/m2) women, two of whom underwent pre-irradiation simple hysterectomy, were definitively treated with radiation for cancer of the cervix. All cases were FIGO stage IB. The average age was 49 years and average body mass index 49 kg/m2. Radioth...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Atypical polypoid adenomyoma (APA) is a rare, benign lesion. The tumor occurs in nulliparous women aged 22-48 years (average 33 years) and it has been suggested as being related to prolonged estrogenic stimulation. We describe a case of a 72-year-old woman who presented at our hospital with persistent, worsening urina...
journal_title:European journal of gynaecological oncology
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更新日期:2012-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:2009-01-01 00:00:00
abstract::All malignant cells appear to have increased needs for glucose in vitro as well as in vivo. The enhanced glucose uptake is mediated through transporters (Gluts), whose action and expression are regulated by oncogenes and growth factors. Cyclin D1 is a nuclear protein that plays an important role in regulating the cell...
journal_title:European journal of gynaecological oncology
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更新日期:2003-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00