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CaMKII and its role in cardiac arrhythmia.

Abstract：

:Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death.

journal_name

J Cardiovasc Electrophysiol

journal_title

Journal of cardiovascular electrophysiology

authors

Erickson JR,Anderson ME

doi

10.1111/j.1540-8167.2008.01295.x

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1332-6

issue

12

eissn

1045-3873

issn

1540-8167

pii

JCE1295

journal_volume

19

pub_type

杂志文章

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