Abstract:
INTRODUCTION:Vancomycin is used in pediatric patients usually at 40 mg/kg/day four times daily. Recent data demonstrated the need of large doses to reach therapeutic concentrations in critical patients. OBJECTIVE:Describe dosage regime of vancomycin in patients from a pediatric intensive care unit, register values of plasmatic concentrations and determine the regimes necessary to reach therapeutic troughs. POPULATION, MATERIALS AND METHODS: We made an observational, retrospective study. Patients who received vancomycin by more than two days where studied. Patients who didn't register vancomycin troughs (minimum values) and/or with elevated serum creatinine were excluded. The age, grouping in younger than (<) 2 years and older than (>) 2 years and troughs of vancomycin were registered. Volume of distribution (Vd) and half-life (t 1/2) were obtained. Results. We studied 97 patients. Patients with undetectable plasmatic concentrations younger than two years were 14 and the older ones were 9, this difference was not statistically significant (p= 0.063). Mediam of the regime of administration for the younger group was 50 mg/kg/day each 6 h and for the older 40 mg/kg/day four times a day. Mediam (range) of Vd and half-life (t 1/2) for the group of < 2 years and >2 years were 0.682 (0.504-1.06) L/kg, 6.12 (2.66-17.49) h; 0.685 (0.389-1.198) L/kg, 4.88 (3.59-15.4) h, without significant differences. CONCLUSIONS:Dosage regime required an increase in frequency, in addition there were no significant differences between pharmacokinetic parameters and final administration regime for both groups, being able to suppose that equal schemes of administration could be implemented more frequently.
journal_name
Arch Argent Pediatrjournal_title
Archivos argentinos de pediatriaauthors
Zylbersztajn BL,Travaglianti M,Weller G,Mato HGsubject
Has Abstractpub_date
2008-02-01 00:00:00pages
26-31issue
1eissn
0325-0075issn
1668-3501pii
S0325-00752008000100006journal_volume
106pub_type
杂志文章abstract::Castleman's disease (CD) is a rare entity, characterized by lymph node follicles hyperplasia. It rarely occurs in children. We present a case of a 9 year old girl with CD in the parotid region. This disease, although it's low incidence in pediatric population, may mimic a malignant neoplasm and should be a differentia...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.1590/S0325-00752013000400016
更新日期:2013-07-01 00:00:00
abstract::Mucopolysaccharidosis I (MPS I) is a rare, recessively inherited, lysosomal storage disorder caused by deficiency on the enzyme a-L-iduronidase. This defect results in accumulation of heparan and dermatan sulfate in different tissues and organs due to a deficiency in the catabolism of glycosaminoglycans. The overall i...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2012.e103
更新日期:2012-10-01 00:00:00
abstract::Preeclampsia affects between 4% to 8% of all human pregnancies. It compromised both mothers and offspring beyond perinatal period. This is the second of two papers devoted to show the available evidence about the effect of preeclampsia on offsprings beyond perinatal period from cohort studies, some over 60-years follo...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章,评审
doi:10.1590/S0325-00752011000600009
更新日期:2011-12-01 00:00:00
abstract::The number of adolescent patients with chronic diseases and special heath needs are increasing, and they are reaching adulthood. Sometimes the passage to the adult health care is abrupt, depending upon the chronological age reached or because of an acute health problem that requires hospitalization. In order to facili...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2012.341
更新日期:2012-08-01 00:00:00
abstract::The 22q11.2 microdeletion is the most common deletion syndrome, with a prevalence of 1/4000-1/6000 among newborn infants and a wide phenotypic variability. The diagnosis of the 22q11.2 microdeletion is made through cytogenetics or fuorescence in situ hybridization (FISH). The objectives of this article were to describ...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2013.423
更新日期:2013-10-01 00:00:00
abstract:INTRODUCTION:When height cannot be measured or does not account for actual bone growth in children, due to their condition, it may be estimated using equations based on body segments. OBJETIVES:1. To compare observed height (OH) and predicted height (PH) based on body segments using the equations of Gauld et al. 2. To...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2018.eng.e721
更新日期:2018-12-01 00:00:00
abstract::A 2-year-old boy was admitted with diagnosis of diabetes debut, with blood glucose of 500 mg% on admission, without ketosis or metabolic acidosis. He also presented bilious vomiting and brownish bloody stools. He was operated with a presumptive diagnosis of acute intestinal obstruction. The final diagnosis was volvulu...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.1590/S0325-00752011000600015
更新日期:2011-12-01 00:00:00
abstract::Skin and soft tissue infections are a common reason for consultation in primary health care centers. Data from the local epidemiology of these infections are rare, but Staphylococcus aureus and Streptococcus pyogenes are known to be the major etiologic agents. The appearance in recent years of community-originated str...
journal_title:Archivos argentinos de pediatria
pub_type: 共识发展会议,杂志文章
doi:10.5546/aap.2014.96
更新日期:2014-02-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2017.eng.439
更新日期:2017-10-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2018.eng.146
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To analyze survival and relevant morbidity by gestational age (GA) in very low birth weight (VLBW) infants (<1500 g) and, based on these data, develop a fact sheet to provide information to perinatal healthcare providers and very low birth weight preterm infants' parents. STUDY DESIGN:Data were prospectively...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章,多中心研究
doi:10.5546/aap.2014.405
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Despite the impact that training in research could have in postgraduate programs, certain specific knowledge of the trainees may increase their scientific production. We described the scientific production of a pediatric residency, and evaluated its association with specific knowledges and activities. MET...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.1590/S0325-00752009000100007
更新日期:2009-02-01 00:00:00
abstract::Carotenemia is generally benign and usually caused by excessive intake of beta-carotene rich food. This clinical presentation can occur in any age group but frequently occurs in children. We report a rare case of carotenemia with an isolated involvement of the nose and presented in order to remind carotenemia in the d...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2019.eng.e502
更新日期:2019-10-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章,评审
doi:10.5546/aap.2017.eng.391
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:The analysis of free fetal DNA in maternal plasma allows the assessment of fetal genetic material avoiding the necessity of invasive procedures during pregnancy. OBJECTIVE:To evaluate the feasibility and the diagnostic performance of fetal sex and fetal RhD detection through the analysis of free fetal DNA...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.1590/S0325-00752009000500006
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Hodgkin's lymphoma (HL) is one of the most curable pediatric cancers, however it is rare among children under five years of age and prognostic factors for survival rate are still unknown due to low frequency in this age group. OBJECTIVES:The aim of this study was to evaluate clinical characteristics, treatm...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2019.eng.e459
更新日期:2019-10-01 00:00:00
abstract:UNLABELLED:There are few data in the literature related to polysomnography in infants in altitudes from 2,200 m to 2,800 m. The main objective of this investigation was to describe oxygen saturation (SpO2) levels during sleep in infants aged between 1 and 4 months living at an altitude of 2,560 m. The secondary objecti...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2015.341
更新日期:2015-08-01 00:00:00
abstract::In patients with malformations and delayed psychomotor development it is important to discard chromosomopathies. Balanced reciprocal translocations are the most frequent chromosomopathies present in 1:500 live newborns. In general, carriers have normal phenotype, but they may have infertility, abortions or children wi...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2018.e603
更新日期:2018-08-01 00:00:00
abstract:INTRODUCTION:Antibiotics are the most prescribed drugs in pediatric intensive care units (PICU) with high impact in pathogens resistance and costs. OBJECTIVES:Evaluate prescription patterns and consumption of antibiotics. MATERIALS AND METHODS:From July 2006 to January 2007, monthly cross-sectional cuts were done on ...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.1590/S0325-00752008000500007
更新日期:2008-10-01 00:00:00
abstract::There are few studies on the use of illicit drugs during pregnancy with a variable prevalence depending on the year, maternal age, region and diagnostic methods. Mothers' and newborn infants' urine samples were tested for illegal drugs in cases where the mother reported consumption, lack of antenatal care and neonatal...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2013.232
更新日期:2013-06-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2020.eng.217
更新日期:2020-06-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章,评审
doi:10.1590/S0325-00752011000300008
更新日期:2011-06-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2020.eng.11
更新日期:2020-02-01 00:00:00
abstract::Incontinentia pigmenti (IP) is a rare genodermatosis. Skin lesions, that are present in all patients affected, evolve in stages. The first is the erythematous blistering stage, wich differential diagnosis includes a wide variety of diseases. We present a case of a female neonate with blisters present at birth, where t...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.1590/S0325-00752011000300015
更新日期:2011-06-01 00:00:00
abstract::Anemia is very common in infants. Although its causes are usually not severe and treatable, proper etiologic diagnosis should be established. When anemia is non-regenerative, it can be caused by aplastic anemia, myelodysplastic syndrome, bone marrow infiltration or hematopoietic factors deficiencies. Another possible ...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2017.e24
更新日期:2017-02-01 00:00:00
abstract::Congenital malformations are a known cause of intrauterine death; of them, congenital heart diseases (CHDs) are accountable for the highest fetal and neonatal mortality rates. They are strongly associated with other extracardiac malformations and an early fetal mortality. Two hundred and twenty fves cases of CHDs are ...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.1590/S0325-00752013000500010
更新日期:2013-10-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 指南
doi:10.5546/aap.2019.S175
更新日期:2019-08-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2020.eng.56
更新日期:2020-02-01 00:00:00
abstract::Kartagener Syndrome is an inherited autosomal recessive disorder characterized by primary ciliary dyskinesia and the triad of situs inversus viscerum, chronic sinus disease and bronchiectasis. Its prevalence varies from 1/15 000 to 1/30 000 but it is estimated that a lot of patients with primary ciliary dyskinesia hav...
journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2019.e292
更新日期:2019-06-01 00:00:00
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journal_title:Archivos argentinos de pediatria
pub_type: 杂志文章
doi:10.5546/aap.2019.eng.381
更新日期:2019-12-01 00:00:00