当前位置： SCI文献检索 > Journal of Pediatric Urology期刊下所有文献 > Hypospadias and anorectal malformations mediated by Eph/ephrin signaling.

Hypospadias and anorectal malformations mediated by Eph/ephrin signaling.

Abstract：

:PURPOSE: Despite extensive research, the molecular basis of hypospadias and anorectal malformations is poorly understood, likely due to a multifactorial basis. The incidence of hypospadias is increasing, thus making research in this area warranted and timely. This review presents recent molecular work broadening our understanding of these disorders. MATERIALS AND METHODS: A brief review of our recent work and the literature on the role of Eph/ephrin signaling in hypospadias and anorectal malformations is presented. RESULTS: Genetically engineered mice mutant for ephrin-B2 or EphB2;EphB3 manifest a variety of genitourinary and anorectal malformations. Approximately 40% of adult male heterozygous mice demonstrate perineal hypospadias. Although homozygous mice die soon after birth, 100% of homozygous males demonstrate high imperforate anus with urethral anomalies and 100% of homozygous females demonstrate persistent cloaca. Male mice compound homozygous for EphB2(ki/ki);EphB3(Delta/Delta)/ also demonstrate hypospadias. CONCLUSIONS: These mouse models provide compelling evidence of the role of B-class Eph/ephrin signaling in genitourinary/anorectal development and add to our mechanistic and molecular understanding of normal and abnormal embryonic development. As research on the B-class Ephs and ephrins continues, they will likely be shown to be molecular contributors to the multifactorial basis of hypospadias and anorectal malformations in humans as well.

journal_name

J Pediatr Urol

journal_title

Journal of pediatric urology

authors

Yucel S,Dravis C,Garcia N,Henkemeyer M,Baker LA

doi

10.1016/j.jpurol.2007.01.199

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

354-363

issue

5

eissn

1477-5131

issn

1873-4898

pii

S1477-5131(07)00223-9

journal_volume

3

pub_type

杂志文章

相关文献

Journal of Pediatric Urology文献大全
  • A tailored surgical approach to the palpable undescended testis.

    abstract：INTRODUCTION:Orchiopexy for a palpable undescended testis can be approached through a traditional inguinal incision or trans-scrotally. Despite the possible advantages of the scrotal approach, including reduced postoperative pain and shorter recovery, it is not consistently advocated. OBJECTIVE:The objective of this s...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2018.08.022

    authors： Neheman A,Levitt M,Steiner Z

    更新日期：2019-02-01 00:00:00

  • Prevalence and predictors of childhood enuresis in southwest Nigeria: Findings from a cross-sectional population study.

    abstract：INTRODUCTION:Childhood enuresis is common, but the prevalence and factors associated with childhood enuresis in Africa have been poorly described. Furthermore, most studies from the continent have not provided data distinguishing monosymptomatic from non-monosymptomatic enuresis. This distinction is important as it gui...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2015.06.009

    authors： Esezobor CI,Balogun MR,Ladapo TA

    更新日期：2015-12-01 00:00:00

  • Urethral advancement in hypospadias with a distal division of the corpus spongiosum: outcome in 158 cases.

    abstract：OBJECTIVE:Outcome of urethral mobilization and advancement (Koff procedure) in hypospadias with a distal division of the corpus spongiosum and redo cases with distal urethral failure. MATERIALS AND METHODS:From January 1999 to November 2012, 158 children with a distal hypospadias (115 primary cases and 43 redo cases) ...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2013.10.019

    authors： Thiry S,Gorduza D,Mouriquand P

    更新日期：2014-06-01 00:00:00

  • Definitive identification of a patent processus vaginalis by intraoperative injection of methylene blue into the hydrocoele sac.

    abstract：OBJECTIVE:Seven percent of patent processus vaginalis (PPVs) are obliterated at exploration. This potentially increases the risk of cord injury with a subsequent increased risk of testicular atrophy or reduced fertility. We report a modification of a technique to improve identification of the PPV and thus potentially m...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2007.08.008

    authors： Calleary JG,Wiseman O,Masood J,Hill JT

    更新日期：2008-06-01 00:00:00

  • Transumbilical laparoendoscopic single-site gonadectomy for Turner's syndrome with Y-chromosome mosaicism.

    abstract：:Laparoendoscopic single-site surgery (LESS), a minimally invasive procedure, is gaining widespread acknowledgment in pediatric urology. We report the case of a 7-year-old girl with Turner's syndrome with 45,XO/46,XY mosaicism, for whom bilateral prophylactic gonadectomy using LESS was performed. Histopathological find...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2012.02.010

    authors： Mizuno K,Kojima Y,Nishio H,Tozawa K,Mizuno H,Kohri K,Hayashi Y

    更新日期：2012-08-01 00:00:00

  • History and physical examination findings predictive of testicular torsion: an attempt to promote clinical diagnosis by house staff.

    abstract：OBJECTIVE:To standardize the history and physical examination of boys who present with acute scrotum and identify parameters that best predict testicular torsion. MATERIALS AND METHODS:Over a 5-month period, a standardized history and physical examination form with 22 items was used for all boys presenting with scrota...

    journal_title：Journal of pediatric urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jpurol.2010.12.010

    authors： Srinivasan A,Cinman N,Feber KM,Gitlin J,Palmer LS

    更新日期：2011-08-01 00:00:00

  • Overactive bladder (OAB): A symptom in search of a disease - Its relationship to specific lower urinary tract symptoms and conditions.

    abstract：BACKGROUND:The ICCS defines OAB by the subjective symptom of urgency; detrusor overactivity (DO) is only implied. While no other symptom is required, OAB can also be associated with urinary frequency, decreased functional bladder capacity, and incontinence. OBJECTIVE:We sought to determine how often these associated f...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2017.02.010

    authors： Van Batavia JP,Combs AJ,Fast AM,Glassberg KI

    更新日期：2017-06-01 00:00:00

  • Congenital renal anomalies in cloacal exstrophy: Is there a difference?

    abstract：INTRODUCTION:Cloacal exstrophy (CE) is the most severe manifestation of the epispadias-exstrophy spectrum. Previous studies have indicated an increased rate of renal anomalies in children with classic bladder exstrophy (CBE). Given the increased severity of the CE defect, it was hypothesized that there would be an even...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2016.04.008

    authors： Suson KD,Inouye B,Carl A,Gearhart JP

    更新日期：2016-08-01 00:00:00

  • Hydronephrosis and crossing vessels in children: Optimization of diagnostic-therapeutic pathway and analysis of color Doppler ultrasound and magnetic resonance urography diagnostic accuracy.

    abstract：INTRODUCTION:Ureteropelvic junction obstruction (UPJO) is one of the most frequent urological diseases affecting the pediatric population. It can be due to both intrinsic stenosis of the junction and extrinsic causes such as the presence of crossing vessels (CVs), which can be detected by color Doppler ultrasound (CD-U...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2017.09.019

    authors： Wong MCY,Piaggio G,Damasio MB,Molinelli C,Ferretti SM,Pistorio A,Ghiggeri G,Degl'Innocenti ML,Canepa A,Incarbone V,Mattioli G

    更新日期：2018-02-01 00:00:00

  • Post-traumatic urethral strictures in children: what have we learned over the years?

    abstract：BACKGROUND:Urethral stricture presents an uncommon but difficult urological problem in the pediatric population. Treatment protocols are different from in adults due to anatomical considerations. MATERIAL AND METHODS:A thorough manual and Medline search was conducted to review the existing literature on post-traumatic...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpurol.2011.06.004

    authors： Ranjan P,Ansari MS,Singh M,Chipde SS,Singh R,Kapoor R

    更新日期：2012-06-01 00:00:00

  • Peristeen integrated transanal irrigation system successfully treats faecal incontinence in children.

    abstract：OBJECTIVE:Faecal incontinence secondary to myelomeningocele, Hirschsprung disease, and anorectal anomalies remains a significant and common problem. We aimed to report our 5-year experience with the Peristeen trans-anal irrigation system (TAIS) to manage such children. PATIENTS AND METHOD:This study was a combination ...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2013.08.006

    authors： Corbett P,Denny A,Dick K,Malone PS,Griffin S,Stanton MP

    更新日期：2014-04-01 00:00:00

  • Continent urinary diversion with a urachal remnant.

    abstract：:The Mitrofanoff procedure, first described in 1980, has been widely adopted for pediatric continent urinary diversion to increase patient independence and continence, decrease morbidity and infections, and preserve renal function. Although this principle employs the appendix primarily, numerous other tissue conduits h...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2005.02.001

    authors： Al-Omar O,Fisher MB,McLorie GA

    更新日期：2005-10-01 00:00:00

  • No stone unturned: The epidemiology and outcomes of paediatric urolithiasis in Manchester, United Kingdom.

    abstract：BACKGROUND:The epidemiology and risk factors for paediatric urolithiasis (UL) in developed countries are evolving, with increasing rates of metabolic stone-formers. In the United Kingdom (UK), only a single London cohort has been studied in the past three decades. Regional disease patterns across the UK remain unknown....

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2020.03.009

    authors： Robinson C,Shenoy M,Hennayake S

    更新日期：2020-06-01 00:00:00

  • Does a serious game increase intrinsic motivation in children receiving urotherapy?

    abstract：INTRODUCTION:Urotherapy is considered the treatment of choice for children suffering daytime urinary incontinence (DUI). Urotherapy intends to improve bladder dysfunction for children with DUI. For children with refractory DUI, an intensive inpatient bladder training program exists, which focuses on relearning, concent...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2018.09.003

    authors： Nieuwhof-Leppink AJ,de Jong TPVM,van de Putte EM,Schappin R

    更新日期：2019-02-01 00:00:00

  • Imaging modalities and treatment of paediatric upper tract urolithiasis: A systematic review and update on behalf of the EAU urolithiasis guidelines panel.

    abstract：BACKGROUND:Prompt diagnosis and treatment of paediatric urolithiasis are required to avoid long term sequelae of renal damage. OBJECTIVE:To systematically review the literature regarding the diagnostic imaging modalities and treatment approaches for paediatric urolithiasis. STUDY DESIGN:PubMed, Science Direct, Scopus...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpurol.2020.07.003

    authors： Grivas N,Thomas K,Drake T,Donaldson J,Neisius A,Petřík A,Ruhayel Y,Seitz C,Türk C,Skolarikos A

    更新日期：2020-10-01 00:00:00

  • A simple screening tool for an unfavorable bladder in children with myelomeningocele: Is the height to width ratio of the cystogram useful to predict high-pressure bladder?

    abstract：INTRODUCTION:Videourodynamics is the key follow-up examination of children with myelomeningocele. However, it has been performed in specific institutions focused on the urological management of children due to the difficulty in its interpretation. Although a neurogenic bladder frequently appears elongated vertically an...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2020.09.015

    authors： Kumano Y,Hayashi C,Gohbara A,Yamazaki Y

    更新日期：2020-12-01 00:00:00

  • Normal pelvic ultrasound or MRI does not rule out neoplasm in patients with gonadal dysgenesis and Y chromosome material.

    abstract：INTRODUCTION:Patients with gonadal dysgenesis (GD) with a Y chromosome have an increased risk of gonadal neoplasm. Few data exist on the ability of imaging to detect malignancy in intra-abdominal gonads in these patients. OBJECTIVE:We aimed to determine the correlation between preoperative imaging findings and gonadal...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2017.11.009

    authors： Ebert KM,Hewitt GD,Indyk JA,McCracken KA,Nahata L,Jayanthi VR

    更新日期：2018-04-01 00:00:00

  • Augmentation ureterocystoplasty in boys with valve bladder syndrome.

    abstract：OBJECTIVE:Children with valve bladder syndrome represent the worst end of the posterior urethral valve spectrum. When conservative measures fail to control recurrent infections, prevent deterioration of the upper tract (in the form of increasing hydronephrosis and or worsening of kidney function) and improve incontinen...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2007.06.005

    authors： Youssif M,Badawy H,Saad A,Hanno A,Mokhless I

    更新日期：2007-12-01 00:00:00

  • Assessment of serum level of corticotropin-releasing factor in primary nocturnal enuresis.

    abstract：INTRODUCTION:Primary nocturnal enuresis is one of the sleep related phenomena characterized by disruption in the relationship between arousal and urination. Corticotropin-releasing factor (CRF) is a neurohormone released from the paraventricular nucleus of the hypothalamus into the median eminence to elicit release of ...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2016.08.030

    authors： Motawie AA,Abd Al-Aziz AM,Hamed HM,Fatouh AA,Awad MA,El-Ghany AA

    更新日期：2017-02-01 00:00:00

  • Successful management of urethro-ileal pouch fistula by cynoacrylate glue instillation.

    abstract：:Uro-enteric fistulae are difficult clinical conditions that have a significant bearing on the patient's quality of life. Surgical correction, though challenging, is the usual mode of treatment offered to these patients. We describe a case of urethro-ileal pouch fistula which could be managed successfully without surge...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2011.06.007

    authors： Jindal T,Sharma RK,Kamal MR,Mandal SN,Mukherjee S,Karmakar D

    更新日期：2012-02-01 00:00:00

  • Adolescent testicular microlithiasis: A case-based, multinational survey of clinical management practices.

    abstract：INTRODUCTION:Testicular microlithiasis (TM) is a condition characterized by calcium deposits within the testis, usually detected incidentally during ultrasonography of the scrotum. TM has been associated with the presence of, and possibly the development of, testicular malignancy. Our aim was to document international ...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2017.12.007

    authors： Brodie KE,Saltzman AF,Cost NG

    更新日期：2018-04-01 00:00:00

  • Laparoscopic intra-abdominal patent processus vaginalis ligation in pediatric urology practice.

    abstract：INTRODUCTION AND OBJECTIVE:Inguinal hernias and communicating hydroceles from a patent processus vaginalis (PPV) are common problems in children. This study provides a detailed description of the laparoscopic intra-abdominal patent processus vaginalis ligation (LIPPL) procedure along with its results in pediatric urolo...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2017.03.026

    authors： Baradaran N,Wood CM,McCoy OO,Prasad MM,Stec AA

    更新日期：2017-10-01 00:00:00

  • Does smoking exposure affect response to treatment in children with primary monosymptomatic nocturnal enuresis?

    abstract：BACKGROUND:There are many variables affecting the success of treatment in children with primary monosymptomatic nocturnal enuresis (PMNE). This study investigates the possible effect of cigarette smoke exposure on desmopressin treatment response in children with PMNE. METHOD:The medical records of pediatric patients w...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2019.10.012

    authors： Kaya Aksoy G,Semerci Koyun N,Doğan ÇS

    更新日期：2020-02-01 00:00:00

  • Anterior urethral valves - A rare but challenging congenital pathology.

    abstract：BACKGROUND:Anterior urethral valves (AUV) and associated anterior urethral diverticula (AUD) are a rare cause of congenital lower urinary tract obstruction. They occur 25-30 times less frequently than posterior urethral valves (PUV) and historically tend to have a less aggressive presentation and outcome. However, due ...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2020.03.024

    authors： Sheth KR,White JT,Bilgutay AN,Seth A,Mittal AG

    更新日期：2020-10-01 00:00:00

  • A critical appraisal of continence in bladder exstrophy: Long-term outcomes of the complete primary repair.

    abstract：INTRODUCTION:Long-term continence outcomes for patients with bladder exstrophy are lacking in the literature. The complete primary repair of exstrophy (CPRE) is a widely adopted approach that seeks to normalize anatomy at the initial repair, thereby allowing early bladder filling and cycling. Previous reports of contin...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2016.04.005

    authors： Ellison JS,Shnorhavorian M,Willihnganz-Lawson K,Grady R,Merguerian PA

    更新日期：2016-08-01 00:00:00

  • Robot-assisted repair of a urogenital sinus with an anorectal malformation in a patient with McKusick-Kaufman syndrome.

    abstract：INTRODUCTION:A urogenital sinus (US) and an anorectal malformation (ARM) are a rare constellation of anomalies, and the optimal surgical approach is unclear. Open and laparoscopic approaches have been described for US and ARM, but no data exist to support robotic assistance in children. CASE:A 20-month-old Amish femal...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2019.08.001

    authors： Phillips MR,Linden AF,Vinocur CD,Hagerty JA

    更新日期：2019-10-01 00:00:00

  • Intravesical instillation of ropivacaine reduces bladder spasms following paediatric ureteroneocystostomy.

    abstract：OBJECTIVE:Bladder spasms are a common cause of pain after surgical procedures that call for postoperative catheter drainage. Several therapeutic methods have been used to lessen these spasms but none have received widespread success. PATIENTS AND METHODS:Twenty-six children were included in a prospective randomized tr...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2006.11.003

    authors： Harper L,Semjen F,Bordes M,Lavrand F,Herault AL,Vergnes P,Dobremez E

    更新日期：2007-08-01 00:00:00

  • Urinary flow patterns in infants with distal hypospadias.

    abstract：OBJECTIVE:To investigate preoperative urinary flow patterns in hypospadic infants and compare them to those from normal infant boys. PATIENTS AND METHODS:Twenty-one boys (median age 14.0, range 12.8-21.6 months) referred for distal hypospadias surgery were compared to 19 healthy boys (median age 12.0, 9.2-19.8 months)...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2010.05.013

    authors： Olsen LH,Grothe I,Rawashdeh YF,Jørgensen TM

    更新日期：2011-08-01 00:00:00

  • Current pharmacological management of idiopathic overactive bladder in children in the UK: a national survey of practice.

    abstract：BACKGROUND:Children with daytime urinary incontinence secondary to idiopathic overactive bladder (IOAB) commonly present to paediatric urologists following failure of standard urotherapy and/or 1st-line anticholinergics. Off-label oral medications and intravesical botulinum toxin A (BtA) are being increasingly used for...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2019.10.013

    authors： Melling CV,Goyal A

    更新日期：2020-02-01 00:00:00

  • Predictors of upper tract damage in pediatric neurogenic bladder.

    abstract：INTRODUCTION:Upper tract damage (UTD) is a life-threatening complication of neurogenic bladder (NB). Early identification of risk factors for UTD and institution of remedial measures may probably prevent UTD. The aim was to study the predictors of UTD in children 2 years or older with NB. METHOD:This cross-sectional, ...

    journal_title：Journal of pediatric urology

    pub_type： 杂志文章

    doi：10.1016/j.jpurol.2017.02.026

    authors： Prakash R,Puri A,Anand R,Jain AK,Lal B,Garg V

    更新日期：2017-10-01 00:00:00