Abstract:
BACKGROUND:In contrast to laparoscopic tubal ligation, oophorectomy, and appendectomy, laparoscopic distal pancreatectomy is associated with a morbidity rate of more than 50% and a mortality rate of more than 3%. OBJECTIVE:To develop a minimally invasive, transgastric endoscopic technique for distal pancreatectomy in a nonsurvival series in swine. DESIGN:Experimental study. SETTING:Animal trial at a tertiary-care academic hospital. SUBJECTS:Six healthy Yorkshire swine under general anesthesia. INTERVENTIONS:A double-channel gastroscope was introduced into the stomach, and a gastric incision was created by using a triple-lumen, 4-mm, cutting-wire needle knife. The peritoneal cavity was accessed. An Endoloop was placed endoscopically around the distal aspect of the pancreas, and the tail of the pancreas was transected by using a diathermic snare. One to 3 hemoclips were placed across the pancreatic duct. The pancreatic specimen was retrieved, and the gastrotomy was closed endoscopically with metal clips. The animals were euthanized after the procedure. The abdominal cavity was examined grossly, and the resected pancreas was examined histologically. MAIN OUTCOME AND MEASUREMENTS:Feasibility of endoscopic transgastric distal pancreatectomy and rate of complications. RESULTS:The pancreatic tail was successfully resected via a transgastric endoscopic approach in all animals. The procedure took an average (standard deviation) of 77.3 +/- 18.9 minutes. There was 1 complication, an episode of bleeding from a splenic laceration, which resulted in the loss of 250 mL of blood. LIMITATIONS:Nonsurvival series, animal study. CONCLUSIONS:Transgastric endoscopic distal pancreatectomy is technically feasible and can be performed in the porcine animal model.
journal_name
Gastrointest Endoscjournal_title
Gastrointestinal endoscopyauthors
Matthes K,Yusuf TE,Willingham FF,Mino-Kenudson M,Rattner DW,Brugge WRdoi
10.1016/j.gie.2007.02.042subject
Has Abstractpub_date
2007-10-01 00:00:00pages
762-6issue
4eissn
0016-5107issn
1097-6779pii
S0016-5107(07)00345-8journal_volume
66pub_type
杂志文章abstract:BACKGROUND:Acute nonvariceal upper-GI hemorrhage (NVUGIH) is associated with significant morbidity and mortality. OBJECTIVE:To examine the relationship between hospital volume and outcomes of NVUGIH. DESIGN:A cross-sectional study. SETTING:Participating hospitals from the Nationwide Inpatient Sample 2004. PATIENTS:...
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journal_title:Gastrointestinal endoscopy
pub_type: 临床试验,杂志文章
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更新日期:1996-09-01 00:00:00
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更新日期:2006-10-01 00:00:00
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journal_title:Gastrointestinal endoscopy
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.gie.2015.12.034
更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Gastrointestinal endoscopy
pub_type: 杂志文章
doi:10.1067/mge.2001.115335
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journal_title:Gastrointestinal endoscopy
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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