Abstract:
:A family of nanoparticles has been fabricated featuring cationic amino acid-based side chains. This controlled surface modification provides a tool to investigate the effect of various non-covalent interactions at the nanoparticle-DNA interface. The binding affinities of these nanoparticles towards DNA were determined using fluorescence, exhibiting more than threefold modulation in binding a 37-mer DNA strand. The secondary structure of the DNA strand was distorted upon nanoparticle binding, with the extent of distortion dependent on the structure of amino acid side chain.
journal_name
Chem Biol Drug Desjournal_title
Chemical biology & drug designauthors
Ghosh PS,Han G,Erdogan B,Rosado O,Krovi SA,Rotello VMdoi
10.1111/j.1747-0285.2007.00534.xsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
13-8issue
1eissn
1747-0277issn
1747-0285pii
JPP534journal_volume
70pub_type
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