Effects of naloxone on prolactin-secreting pituitary adenomas.

Abstract:

:The investigators assessed the effects of the opioid antagonist naloxone on anterior pituitary hormone release in hyperprolactinemic females with pituitary microadenoma (n = 6) and macroadenoma (n = 7). In those with microadenoma, intravenous bolus injection of naloxone significantly increased serum luteinizing hormone (LH) concentrations but had no significant effect on serum prolactin (PRL), follicle-stimulating hormone, and thyroid-stimulating hormone concentrations. In patients with macroadenoma, naloxone significantly decreased serum LH and serum PRL concentrations. The response of LH to naloxone differed considerably between the two groups of patients. The results suggest that LH and PRL secretion is influenced by changes in endogenous opiates and in gonadotropin-releasing hormone and PRL inhibitory factor due to hypothalamic dysfunction.

authors

Shima K,Chigasaki H,Seki K

doi

10.2176/nmc.30.109

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

109-12

issue

2

eissn

0470-8105

issn

1349-8029

pii

JST.Journalarchive/nmc1959/30.109

journal_volume

30

pub_type

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