MGOUN3: evidence for chromatin-mediated regulation of FLC expression.

Abstract:

:The MGOUN3(MGO3)/BRUSHY1(BRU1)/TONSOKU(TSK) gene of Arabidopsis thaliana encodes a nuclear leucine-glycine-asparagine (LGN) domain protein that may be implicated in chromatin dynamics and genome maintenance. Mutants with defects in MGO3 display a fasciated stem and disorganized meristem structures. The transition to flowering was examined in mgo3 mutants and it was found that, under short days, the mutants flowered significantly earlier than the wild-type plants. Study of flowering-time associated gene expression showed that the floral transition inhibitor gene FLC was under-expressed in the mutant background. Ectopic expression of the flower-specific genes AGAMOUS (AG), PISTILLATA (PI), and SEPALLATA3 (SEP3) in mgo3 vegetative organs was also detected. Western blot and chromatin immunoprecipitation experiments suggested that histone H3 acetylation may be altered in the mgo3 background. Together, these data suggest that MGO3 is required for the correct transition to flowering and that this may be mediated by histone acetylation and associated changes in FLC expression.

journal_name

J Exp Bot

authors

Guyomarc'h S,Benhamed M,Lemonnier G,Renou JP,Zhou DX,Delarue M

doi

10.1093/jxb/erj169

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

2111-9

issue

9

eissn

0022-0957

issn

1460-2431

pii

erj169

journal_volume

57

pub_type

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