Abstract:
STUDY DESIGN:T1rho relaxation was quantified and correlated with intervertebral disc degeneration and proteoglycan content in cadaveric human lumbar spine tissue. OBJECTIVE:To show the use of T1rho-weighted magnetic resonance imaging (MRI) for the assessment of degeneration and proteoglycan content in the human intervertebral disc. SUMMARY OF BACKGROUND DATA:Loss of proteoglycan in the nucleus pulposus occurs during early degeneration. Conventional MRI techniques cannot detect these early changes in the extracellular matrix content of the disc. T1rho MRI is sensitive to changes in proteoglycan content of articular cartilage and may, therefore, be sensitive to proteoglycan content in the intervertebral disc. METHODS:Intact human cadaveric lumbar spines were imaged on a clinical MR scanner. Average T1rho in the nucleus pulposus was calculated from quantitative T1rho maps. After MRI, the spines were dissected, and proteoglycan content of the nucleus pulposus was measured. Finally, the stage of degeneration was graded using conventional T2 images. RESULTS:T1rho decreased linearly with increasing degeneration (r = -0.76, P < 0.01) and age (r = -0.76, P < 0.01). Biochemical analysis revealed a strong linear correlation between T1rho and sulfated-glycosaminoglycan content. T1rho was moderately correlated with water content. CONCLUSIONS:Results from this study suggest that T1rho may provide a tool for the diagnosis of early degenerative changes in the disc. T1rho-weighted MRI is a noninvasive technique that may provide higher dynamic range than T2 and does not require a high static field or exogenous contrast agents.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Johannessen W,Auerbach JD,Wheaton AJ,Kurji A,Borthakur A,Reddy R,Elliott DMdoi
10.1097/01.brs.0000217708.54880.51subject
Has Abstractpub_date
2006-05-15 00:00:00pages
1253-7issue
11eissn
0362-2436issn
1528-1159pii
00007632-200605150-00013journal_volume
31pub_type
杂志文章相关文献
SPINE文献大全abstract::A retrospective review of 326 female patients with untreated idiopathic scoliosis was performed to determine what factors might be useful in predicting the risk of curve progression. Components such as family history, height-weight ratio, lumbosacral transitional anomalies, kyphosis, lordosis, and trunk balance were n...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198610000-00003
更新日期:1986-10-01 00:00:00
abstract:STUDY DESIGN:Retrospective database review of a prospectively maintained neurosurgical database. OBJECTIVE:The surgical management of cervical spinal epidural abscesses (CSEA) is reviewed examining the shift from single to staged anteroposterior decompression and stabilization. SUMMARY OF BACKGROUND DATA:CSEA managem...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000942
更新日期:2015-09-01 00:00:00
abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:To investigate the association between preoperative baseline serum albumin and postoperative surgical complication. SUMMARY OF BACKGROUND DATA:The prevalence of malnutrition in the hospitalized patient population has only been recently recognized. Preoperative hypoal...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000450
更新日期:2014-08-15 00:00:00
abstract:STUDY DESIGN:Axial pullout tests using fresh cadaveric thoracolumbar vertebral bodies. OBJECTIVES:To evaluate the effect of a new injectable calcium phosphate cement on the axial pullout strength of both revised and augmented pedicle screws in comparison with polymethyl methacrylate and in terms of injection method. ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200406010-00020
更新日期:2004-06-01 00:00:00
abstract::Does infant malnutrition produce smaller adult spinal canals? Lumbar and thoracic vertebrae (n X 1073), from a prehistoric American Indian population (15-55 yrs of age), were measured for anteroposterior (AP) and transverse (TR) vertebral canal sizes, nerve root tunnel (intervertebral foramen) widths (NRT), vertebral ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198503000-00012
更新日期:1985-03-01 00:00:00
abstract:STUDY DESIGN:The influence of lumbar disc height and cross-sectional area on the mechanical response of the disc to physiologic loading was determined using a finite element model. OBJECTIVES:To identify which geometric characteristics are potentially related to motion segment mechanical response to applied load, such...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199909150-00003
更新日期:1999-09-15 00:00:00
abstract:STUDY DESIGN:A cluster randomized, controlled trial was performed. OBJECTIVES:To assess the clinical effectiveness and cost-effectiveness of adding patients' referral to neuroreflexotherapy intervention to the usual management of subacute and chronic low back pain in routine general practice. SUMMARY OF BACKGROUND DA...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-200206010-00004
更新日期:2002-06-01 00:00:00
abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA:Results of studies analyzing the impact of smoking on complication and pseudarthr...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000527
更新日期:2014-10-01 00:00:00
abstract:STUDY DESIGN:A new way to study pain in experimental animals without handling of the animals and based on registration of spontaneous behavior using video recordings. OBJECTIVES:To evaluate if experimental disc herniation in the rat may induce changes in spontaneous behavior. SUMMARY OF BACKGROUND DATA:The knowledge ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200206150-00013
更新日期:2002-06-15 00:00:00
abstract:STUDY DESIGN:Multicenter, retrospective, consecutive case series. OBJECTIVE:This study aims to identify demographic and radiographical characteristics that influence the decision to perform revision surgery among patients with proximal junctional failure (PJF). SUMMARY OF BACKGROUND DATA:Revision rates after PJF rema...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0b013e31829fedde
更新日期:2013-09-01 00:00:00
abstract:STUDY DESIGN:A retrospective review of 33 consecutive patients treated with posterior fusion and selective nerve root decompression for the treatment of pseudarthrosis following anterior cervical discectomy and fusion. OBJECTIVES:Use standardized outcome measures to evaluate the results of posterior fusion with select...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000184314.26543.7d
更新日期:2005-11-01 00:00:00
abstract::The ability of Elvey's "brachial plexus tension test" to identify pain referred from the cervical region was investigated in 50 patients with unilateral shoulder and upper arm pain: 25 reported symptoms commencing after open heart surgery, indicating a high probability of referred pain due to that procedure; 25 were a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199401000-00006
更新日期:1994-01-01 00:00:00
abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:Evaluate the relationship among the neurologic status, the Thoracolumbar Injury Classification System (TLICS) score, and the Magerl/AO classification system. SUMMARY OF THE BACKGROUND DATA:A wide range of classification schemes for thoracic and lumbar spine trauma have been...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0b013e3181c95047
更新日期:2011-01-01 00:00:00
abstract:STUDY DESIGN:A case report of traumatic atlanto-occipital dislocation managed by transarticular screw fixation. OBJECTIVES:To present a case with initial failed wire fixation but successful reduction and fixation with transarticular screw fixation and occipitocervical plate stabilization. SUMMARY OF BACKGROUND DATA:A...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200103150-00030
更新日期:2001-03-15 00:00:00
abstract:STUDY DESIGN:Prospective, nonrandomized cohort. OBJECTIVE:Describe the surgical technique and clinical outcome of distraction lumbar laminoplasty with allograft bone block augmentation and interlaminar lumbar instrumented fusion (ILIF) SUMMARY OF BACKGROUND DATA.: ILIF is a recently described technique that may offer ...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000001484
更新日期:2016-04-01 00:00:00
abstract:STUDY DESIGN:A combined in vitro and finite-element analysis was completed to assess the biomechanical effect of a new interspinous implant on the lumbar spine. OBJECTIVE:The aim was to investigate the effect of an interspinous implant on the biomechanical behavior of a vertebral segment. METHODS:An in vitro study on...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3180b9f429
更新日期:2007-07-15 00:00:00
abstract::Two examples of a marked defect of the corner of the vertebral body adjacent to an intervertebral disk herniation are presented. The prevalence of this finding was assessed in 43 randomly selected patients with disk herniation (at 46 levels). None of these patients had such marked vertebral defects (moderate changes a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199301000-00016
更新日期:1993-01-01 00:00:00
abstract:STUDY DESIGN:An operator-blinded dual modality trial of measurement of lumbar multifidus muscle cross-sectional area was performed. OBJECTIVE:To compare two imaging modalities used for measurement of the lumbar multifidus muscle. METHODS:Ten normal female subjects aged 21-31 years were imaged on two separate days usi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199501000-00010
更新日期:1995-01-01 00:00:00
abstract:STUDY DESIGN:Review of a prospective database registry. OBJECTIVE:To compare the Scoliosis Research Society (SRS)-22 and SRS-24 outcomes instruments in terms of scores, rate of ceiling effects, and discriminant ability in patients with pre- and postoperative adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000001082
更新日期:2015-12-01 00:00:00
abstract:STUDY DESIGN:Fifty-one consecutive patients who underwent extradural sensory rhizotomy for chronic radiculopathy after lumbar surgery were reviewed retrospectively. OBJECTIVES:To determine the effectiveness of sensory rhizotomy in the management of chronic radiculopathy in patients selected by extensive imaging techni...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199710010-00018
更新日期:1997-10-01 00:00:00
abstract:STUDY DESIGN:We compared anterior and posterior surgery for cervical myelopathy resulting from ossification of the posterior longitudinal ligament. Surgical techniques, based on shape and distribution of ossification of the posterior longitudinal ligament, were divided into four technical phases. OBJECTIVES:Long-term ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199510001-00012
更新日期:1995-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective. OBJECTIVES:To document sagittal translation (ST) of the vertebral column in opening wedge osteotomy (OWO) for ankylosing spondylitis (AS) kyphosis. SUMMARY OF BACKGROUND DATA:Surgeons recognize displacement at the hinge of correction in OWO as an accidental event between the vertebrae on t...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000216479.09250.96
更新日期:2006-05-01 00:00:00
abstract:STUDY DESIGN:In vitro and modeling study of upper cervical spine (UCS) three-dimensional (3D) kinematics and muscle moment arm (MA) during axial rotation (AR) and flexion extension (FE). OBJECTIVE:To create musculoskeletal models with movement simulation including helical axis (HA) and muscle features. SUMMARY OF BAC...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181dc844a
更新日期:2011-03-15 00:00:00
abstract:STUDY DESIGN:A cross-sectional survey among adolescents aged 15-16 years. OBJECTIVE:To evaluate whether physical activity or sedentary activities associate with neck and shoulder symptoms among adolescents. SUMMARY OF BACKGROUND DATA:Findings of associations between physical exercise and neck or shoulder pain in adol...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000261349.94823.c1
更新日期:2007-04-20 00:00:00
abstract:STUDY DESIGN:The effects of electrical stimulation of the sciatic nerve on background electromyographic and static stretch reflex activity of the trunk muscles were studied. OBJECTIVES:To verify the hypotheses that sciatic scoliosis is induced reflexively by radiculopathic pain, and that scoliosis might be maintained ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200103150-00009
更新日期:2001-03-15 00:00:00
abstract:STUDY DESIGN:Retrospective. OBJECTIVE:To examine the relationship between American Society of Anesthesiologists (ASA) score and inpatient pain and narcotics consumption following anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA:Higher ASA scores have been previously linked to increased posto...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003135
更新日期:2019-11-15 00:00:00
abstract:STUDY DESIGN:Systematic review. OBJECTIVE:To determine the population risk of radiographical degeneration in the lumbar and cervical spine as well as the risk of adjacent segment pathology (ASP) among patients who receive and do not receive (but were eligible for) fusion for lumbar or cervical degeneration. SUMMARY O...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31826cac62
更新日期:2012-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of a multicenter database. OBJECTIVE:To evaluate whether surgeon experience is associated with complication rates in adult spinal deformity (ASD) surgery. SUMMARY OF BACKGROUND DATA:Multiple patient- and surgery-related factors have been shown to increase the risk of complications in...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000993
更新日期:2015-08-01 00:00:00
abstract:STUDY DESIGN:A biomechanical study on a pneumatically controlled 7-axis spine simulator using Delron and human cadaveric spine models. OBJECTIVES:To compare the biomechanical properties of an anterior cervical extension plate with comparable-length anterior cervical plates. SUMMARY OF BACKGROUND DATA:Adjacent-level a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000186319.84883.e7
更新日期:2005-11-15 00:00:00
abstract:STUDY DESIGN:The strength of posterior cervical lateral mass fixation was evaluated in a cadaver model for two techniques of screw insertion. OBJECTIVE:To compare the flexion failure strengths of posterior cervical plate fixation for two techniques of screw placement at the superior and inferior screw hole positions, ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199602150-00010
更新日期:1996-02-15 00:00:00