Abstract:
:The majority of disease resistance genes in plants encode nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins. This large family is encoded by hundreds of diverse genes per genome and can be subdivided into the functionally distinct TIR-domain-containing (TNL) and CC-domain-containing (CNL) subfamilies. Their precise role in recognition is unknown; however, they are thought to monitor the status of plant proteins that are targeted by pathogen effectors.
journal_name
Genome Bioljournal_title
Genome biologyauthors
McHale L,Tan X,Koehl P,Michelmore RWdoi
10.1186/gb-2006-7-4-212subject
Has Abstractpub_date
2006-01-01 00:00:00pages
212issue
4eissn
1474-7596issn
1474-760Xpii
gb-2006-7-4-212journal_volume
7pub_type
杂志文章,评审相关文献
GENOME BIOLOGY文献大全abstract:BACKGROUND:One way in which the accuracy of gene structure prediction in vertebrate DNA sequences can be improved is by analyzing alignments with multiple related species, since functional regions of genes tend to be more conserved. RESULTS:We describe DOGFISH, a vertebrate gene finder consisting of a cleanly separate...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2006-7-s1-s6
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards understanding the genomic basis of productivity and adaptation to survival under African fa...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-017-1153-y
更新日期:2017-02-20 00:00:00
abstract:BACKGROUND:Developmental programs are implemented by regulatory interactions between Transcription Factors (TFs) and their target genes, which remain poorly understood. While recent studies have focused on regulatory cascades of TFs that govern early development, little is known about how the ultimate effectors of cell...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2013-14-8-r86
更新日期:2013-08-23 00:00:00
abstract::The recent completion of the DNA sequence of human chromosome 21 has provided the first look at the 225 genes that are candidates for involvement in Down syndrome (trisomy 21). A broad functional classification of these genes, their expression data and evolutionary conservation, and comparison with the gene content of...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2000-1-2-reviews0002
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The direct examination of large, unbiased samples of young gene duplicates in their early stages of evolution is crucial to understanding the origin, divergence and preservation of new genes. Furthermore, comparative analysis of multiple genomes is necessary to determine whether patterns of gene duplication ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2009-10-7-r75
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) comprises a group of diseases characterized by the abnormal development of malignant myeloid cells. Recent studies have demonstrated an important role for aberrant transcriptional regulation in AML pathophysiology. Although several transcription factors (TFs) involved in myeloid ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-2-r38
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The control of energy metabolism is fundamental for cell growth and function and anomalies in it are implicated in complex diseases and ageing. Metabolism in yeast cells can be manipulated by supplying different carbon sources: yeast grown on glucose rapidly proliferates by fermentation, analogous to tumour ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-016-1101-2
更新日期:2016-11-25 00:00:00
abstract::Droplet-based single-cell RNA sequencing protocols have dramatically increased the throughput of single-cell transcriptomics studies. A key computational challenge when processing these data is to distinguish libraries for real cells from empty droplets. Here, we describe a new statistical method for calling cells fro...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-019-1662-y
更新日期:2019-03-22 00:00:00
abstract::Genetic studies have identified more than 150 autoimmune loci, and next-generation sequencing will identify more. Is it time to make human the model organism for autoimmune research? ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2010-11-5-212
更新日期:2010-01-01 00:00:00
abstract::Recent work has identified the human NOD-like receptor NLRX1 as a negative regulator of intracellular signaling leading to type I interferon production. Here we discuss these findings and the questions and implications they raise regarding the function of NOD-like receptors in the antiviral response. ...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb-2008-9-4-217
更新日期:2008-04-25 00:00:00
abstract:BACKGROUND:Long noncoding RNAs (lncRNAs) form an abundant class of transcripts, but the function of the majority of them remains elusive. While it has been shown that some lncRNAs are bound by ribosomes, it has also been convincingly demonstrated that these transcripts do not code for proteins. To obtain a comprehensiv...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-1-r6
更新日期:2014-01-07 00:00:00
abstract::A report on the Epigenetic Engineering Meeting hosted by the Barts Institute of Cancer, held in London, UK, May 7, 2014. ...
journal_title:Genome biology
pub_type:
doi:10.1186/gb4179
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The influence of genetic variation on complex diseases is potentially mediated through a range of highly dynamic epigenetic processes exhibiting temporal variation during development and later life. Here we present a catalogue of the genetic influences on DNA methylation (methylation quantitative trait loci ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-016-0926-z
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:Francisella tularensis subspecies tularensis and holarctica are pathogenic to humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause disease. To uncover the factors that allow subspecies tularensis and holarctica to be pathogenic to humans, we compared their genome sequences with t...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-6-r102
更新日期:2007-01-01 00:00:00
abstract::Two recent studies demonstrate the power of integrating tumor genotype information with epigenetic and proteomic studies to discover potential therapeutic targets in breast cancer. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-017-1238-7
更新日期:2017-05-22 00:00:00
abstract::Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a simple protocol for detection of open chromatin. Computational footprinting, the search for regions with depletion of cleavage events due to transcription factor binding, is poorly understood for ATAC-seq. We propose the first footprinting method ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-019-1642-2
更新日期:2019-02-26 00:00:00
abstract::Not so fast. The Iqbal et. al. study and the associated Whitelaw commentary highlight the appropriately high standards of study design and interpretation needed to obtain good evidence for or against epigenetic inheritance. Please see related article: www.dx.doi.org/10.1186/s13059-015-0714-1. ...
journal_title:Genome biology
pub_type: 评论,信件
doi:10.1186/s13059-015-0709-y
更新日期:2015-07-11 00:00:00
abstract:BACKGROUND:The current bovine genomic reference sequence was assembled from a Hereford cow. The resulting linear assembly lacks diversity because it does not contain allelic variation, a drawback of linear references that causes reference allele bias. High nucleotide diversity and the separation of individuals by hundr...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-020-02105-0
更新日期:2020-07-27 00:00:00
abstract:BACKGROUND:Despite the biological and economic significance of scleractinian reef-building corals, the lack of large molecular datasets for a representative range of species limits understanding of many aspects of their biology. Within the Scleractinia, based on molecular evidence, it is generally recognised that there...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-018-1552-8
更新日期:2018-11-02 00:00:00
abstract:BACKGROUND:Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively neutral and that, following a duplication, one of the gene copies is freed from purifying (stabilizing) selection, which creates the potential for evolut...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2002-3-2-research0008
更新日期:2002-01-01 00:00:00
abstract::Exome sequencing is poised to yield substantial insights into human genetic variation and evolutionary history, but there are significant challenges to overcome before this becomes a reality. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2011-12-9-127
更新日期:2011-09-14 00:00:00
abstract:BACKGROUND:Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are, very likely, two stages of the same phenomenon whose properties still remain substantially obscure. Chromosome 13 is the chromosome with the highest number of neocentromeres. We reconstructed the mammali...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2006-7-10-r91
更新日期:2006-01-01 00:00:00
abstract::Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation minimization, a classical signal restoration technique. In systematic evaluations, we show that our method c...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-1-r13
更新日期:2008-01-21 00:00:00
abstract::Two recent publications have demonstrated how delivering CRISPR nucleases provides a promising solution to the growing problem of bacterial antibiotic resistance. ...
journal_title:Genome biology
pub_type: 评论,杂志文章
doi:10.1186/s13059-014-0516-x
更新日期:2014-11-08 00:00:00
abstract:BACKGROUND:Massively parallel pyrosequencing systems have increased the efficiency of DNA sequencing, although the published per-base accuracy of a Roche GS20 is only 96%. In genome projects, highly redundant consensus assemblies can compensate for sequencing errors. In contrast, studies of microbial diversity that cat...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-7-r143
更新日期:2007-01-01 00:00:00
abstract::Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. Based on this, we introduce a new computational strategy...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2007-8-2-r23
更新日期:2007-01-01 00:00:00
abstract::Prediction of the diagnostic category of a tissue sample from its gene-expression profile and selection of relevant genes for class prediction have important applications in cancer research. We have developed the uncorrelated shrunken centroid (USC) and error-weighted, uncorrelated shrunken centroid (EWUSC) algorithms...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2003-4-12-r83
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Malaria is a one of the most important infectious diseases and is caused by parasitic protozoa of the genus Plasmodium. Previously, quantitative characterization of the P. falciparum transcriptome demonstrated that the strictly controlled progression of these parasites through their intra-erythrocytic develo...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2008-9-12-r177
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Retroviral elements are pervasively transcribed and dynamically regulated during development. While multiple histone- and DNA-modifying enzymes have broadly been associated with their global silencing, little is known about how the many diverse retroviral families are each selectively recognized. RESULTS:He...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-4-r58
更新日期:2014-04-30 00:00:00
abstract:BACKGROUND:Simple sequence repeats (SSRs) in DNA have been traditionally thought of as functionally unimportant and have been studied mainly as genetic markers. A recent handful of studies have shown, however, that SSRs in different positions of a gene can play important roles in determining protein function, genetic d...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2006-7-2-r14
更新日期:2006-01-01 00:00:00