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Sibling risk of pervasive developmental disorder estimated by means of an epidemiologic survey in Nagoya, Japan.

Abstract：

:Broad-spectrum autism, referred to as pervasive developmental disorder (PDD), may be associated with genetic factors. We examined 241 siblings in 269 Japanese families with affected children. The sibling incidence of PDD was 10.0% whereas the prevalence of PDD in the general population in the same geographic region was 2.1%. Both of these rates are higher than those reported previously, probably because of the expanded clinical criteria applied. The prevalence in males of the general population was 3.3% and that in females was 0.82%. The sibling incidences were 7.7 and 20.0% for families in which the probands were male and female, respectively. Because the reversed sex ratios correspond to the general rule for a multifactorial threshold model, we suggest that most PDD cases result from the cumulative effects of multiple factors (mostly genetic). The sibling incidences were 0 and 10.9% for families in which the proband had low and normal birth-weight, respectively, suggesting the risk is lower in families with low-birth-weight probands.

journal_name

J Hum Genet

journal_title

Journal of human genetics

authors

Sumi S,Taniai H,Miyachi T,Tanemura M

doi

10.1007/s10038-006-0392-7

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

518-522

issue

6

eissn

1434-5161

issn

1435-232X

pii

10.1007/s10038-006-0392-7

journal_volume

51

pub_type

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