Abstract:
:We discovered a thalidomide analogue [5-hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33)] with antiproliferative activity against nine cancer cell lines in vitro. Flow cytometric analyses showed that the compound caused G2-M arrest, which occurred mainly at the mitotic phase. In addition, immunofluorescence microscopy and in vitro tubulin polymerization studies showed that 5HPP-33 has antimicrotubule activity with a paclitaxel-like mode of action. It is effective against four different paclitaxel-resistant cell lines. Thus, 5HPP-33 represents a potential antitumor agent.
journal_name
Mol Cancer Therjournal_title
Molecular cancer therapeuticsauthors
Li PK,Pandit B,Sackett DL,Hu Z,Zink J,Zhi J,Freeman D,Robey RW,Werbovetz K,Lewis A,Li Cdoi
10.1158/1535-7163.MCT-05-0254keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
450-6issue
2eissn
1535-7163issn
1538-8514pii
5/2/450journal_volume
5pub_type
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