In vivo MR thermometry of frozen tissue using R2* and signal intensity.

Abstract:

:Cryoablation is one of several minimally invasive treatments that may be suitable for a targeted treatment of prostate cancer. Because efficacy is improved when a sufficiently cold end temperature is reached, the purpose of this work was to demonstrate an image-based thermometry method that could provide temperature maps throughout the frozen tissue. In five in vivo canine prostate cryoablation experiments performed under magnetic resonance imaging guidance, two MR parameters were measured and correlated to temperature: R2* and changes in signal intensity. R2* is elevated approximately linearly as tissue temperature decreases below the freezing point, while the signal intensity decreases exponentially. In vivo temperature maps with isotherms at -5 degrees C, -15 degrees C, and -30 degrees C are demonstrated.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Wansapura JP,Daniel BL,Vigen KK,Butts K

doi

10.1016/j.acra.2005.06.006

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

1080-4

issue

9

eissn

1076-6332

issn

1878-4046

pii

S1076-6332(05)00514-3

journal_volume

12

pub_type

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