Primary breast lymphoma: outcome of 7 patients and a review of the literature.

Abstract:

:Primary breast lymphomas (PBL) are uncommon neoplasms. Seven PBL were diagnosed between March 1993 and October 2002. A lumpectomy (n=4) or radical mastectomy (n=3) was performed; 5 patients were in clinical stage (CS) II and 2 in CS IV; 6 patients received the CEOP regimen (cyclophosphamide, vincristine, epirubicin and prednisone) after surgery and 4 also had additional radiotherapy; 1 patient did not receive any treatment after local excision. Five patients (71%) achieved complete remission and 2 (29%) partial remission, with an overall response rate of 100%. All remitter patients are alive and well after a median follow-up of 75 months (range 10--121 months). Two patients in partial remission died of progressive disease. After a median follow-up of 99 months (range 84--111 months) for surviving patients, the 10 year overall and disease-free survival rates are both 71%, with 5 patients well and still free of disease. We conclude that the optimal sequence of full-dose anthracycline-containing regimens and radiation therapy should be the treatment of choice for patients with PBL.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Vigliotti ML,Dell'olio M,La Sala A,Di Renzo N

doi

10.1080/10428190500126083

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

1321-7

issue

9

eissn

1042-8194

issn

1029-2403

pii

V41676585234447V

journal_volume

46

pub_type

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