Thyroid dysfunction during interferon alpha therapy for chronic hepatitis C.

Abstract:

:Interferon-alpha therapy is well known to induce a wide range of thyroid dysfunction. A 22-year-old woman with chronic hepatitis C developed overt hyperthyroidism while on interferon-alpha and ribavirin therapy. Tc-99m thyroid scintigraphy demonstrated virtually absent tracer uptake consistent with subacute thyroiditis. Ten months after starting antiviral therapy, overt hyperthyroidism recurred. Repeat thyroid scintigraphy revealed diffusely increased tracer uptake throughout the thyroid gland consistent with Graves disease. This is an unusual case of 2 forms of hyperthyroidism-confirmed scintigraphically and occurring in the same patient over time while on interferon-alpha therapy.

journal_name

Clin Nucl Med

authors

Shen L,Bui C,Mansberg R,Nguyen D,Alam-Fotias S

doi

10.1097/01.rlu.0000170014.35693.6c

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

546-7

issue

8

eissn

0363-9762

issn

1536-0229

pii

00003072-200508000-00004

journal_volume

30

pub_type

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