Abstract:
:Most available antimalarial drugs induce cardiac side effects. These side effects include various mild heart rate changes (amodiaquine) to excessive prolongation of the QT interval (halofantrine) which may lead to lethal arrhythmias such as Torsade de Pointes (TdP). The cellular mechanism of such events during antimalarial therapy is principally related to ion channel inhibition (e.g., human ether-a-go-go related gene channel) which may slow the repolarisation process and create a good substrate for arrhythmia (when dispersion of repolarisation is present). However, other antimalarial drugs do not show as potent cardiac side effects, like co-arthemeter and sulfadoxine-pyrimethamine. Considering that TdP are favoured by a complex combination of electrophysiological changes, a predictive cardiosafety strategy for new antimalarial drugs should comprise assays with an increasing level of information from ion channel level, cellular and organ level, to the whole organism. In this review, the actual knowledge on underlying mechanisms of QT prolongation and TdP is described, followed by the cardiac safety profiles of present antimalarial drugs.
journal_name
Expert Opin Drug Safjournal_title
Expert opinion on drug safetyauthors
Traebert M,Dumotier Bdoi
10.1517/14740338.4.3.421keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
421-31issue
3eissn
1474-0338issn
1744-764Xjournal_volume
4pub_type
杂志文章,评审abstract::Colchicine has been used for over 2000 years. Intravenous (i.v.) colchicine has been used for the treatment of acute gout since the 1950s. I.v. and oral colchicine were 'grandfathered' before the 1969 FDA Phase III trials for drug toxicity became law. Data on toxic reactions are, therefore, based only on passive surve...
journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
pub_type: 临床试验,杂志文章
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abstract:INTRODUCTION:Maraviroc is the only C-chemokine receptor 5 (CCR5) antagonist approved for the treatment of infection with HIV. This article reviews the safety and efficacy of maraviroc in the treatment of HIV infection. AREAS COVERED:The PubMed database was searched using the keywords 'maraviroc' and 'HIV'. In addition...
journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,meta分析
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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