Abstract:
:Drugs are currently an important cause of liver disease, ranked as the most frequent reason for acute liver failure. Despite recent advances in knowledge of the mechanisms implicated in drug-induced hepatocellular damage and cholestasis, as well as the identification of several risk factors, the diagnosis of hepatotoxicity remains a difficult task because specific tests are not available. In a step-by-step approach, the incrimination of a drug in liver symptoms requires a high degree of suspicion on the part of the physician, temporal eligibility, awareness of the drug's hepatotoxic potential, the exclusion of alternative causes of liver damage, and the ability to detect the presence of subtle data that favour a toxic aetiology. Ultimately, the use of diagnostic algorithms may add consistency to the diagnostic process either by translating the suspicion into a quantitative score or by providing a framework that emphasises the features that merit attention in cases of suspected hepatic adverse reactions.
journal_name
Expert Opin Drug Safjournal_title
Expert opinion on drug safetyauthors
Andrade RJ,Camargo R,Lucena MI,González-Grande Rdoi
10.1517/14740338.3.4.329keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
329-44issue
4eissn
1474-0338issn
1744-764Xpii
EDS030407journal_volume
3pub_type
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