Abstract:
OBJECTIVE AND IMPORTANCE:Desmoplastic infantile gangliogliomas (DIGs) are extremely rare tumors that respond well to treatment. However, their biological behavior remains to be clarified. We describe two patients whose DIGs spontaneously regressed after surgery, without adjuvant therapy. CLINICAL PRESENTATION:A 9-month-old girl presented with left hemiparesis, and a 6-month-old boy presented with increasing head circumference. For both patients, neuroimaging demonstrated a huge cystic tumor that included a solid portion and was widely attached to the dura. Gadolinium-diethylenetriamine penta-acetic acid produced strong enhancement. INTERVENTION:One patient underwent partial and the other subtotal tumor removal. Histologically, both tumors were diagnosed as DIGs. Postoperatively, the residual tumors were monitored without adjuvant therapy, and both regressed in several months. CONCLUSION:Our experience suggests that DIGs may include a subgroup of tumors with a tendency for spontaneous regression, possibly attributable to the induction of apoptosis.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Takeshima H,Kawahara Y,Hirano H,Obara S,Niiro M,Kuratsu Jdoi
10.1227/01.neu.0000084165.60662.6dkeywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
979-83; discussion 983-4issue
4eissn
0148-396Xissn
1524-4040journal_volume
53pub_type
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