Postoperative regression of desmoplastic infantile gangliogliomas: report of two cases.

Abstract:

OBJECTIVE AND IMPORTANCE:Desmoplastic infantile gangliogliomas (DIGs) are extremely rare tumors that respond well to treatment. However, their biological behavior remains to be clarified. We describe two patients whose DIGs spontaneously regressed after surgery, without adjuvant therapy. CLINICAL PRESENTATION:A 9-month-old girl presented with left hemiparesis, and a 6-month-old boy presented with increasing head circumference. For both patients, neuroimaging demonstrated a huge cystic tumor that included a solid portion and was widely attached to the dura. Gadolinium-diethylenetriamine penta-acetic acid produced strong enhancement. INTERVENTION:One patient underwent partial and the other subtotal tumor removal. Histologically, both tumors were diagnosed as DIGs. Postoperatively, the residual tumors were monitored without adjuvant therapy, and both regressed in several months. CONCLUSION:Our experience suggests that DIGs may include a subgroup of tumors with a tendency for spontaneous regression, possibly attributable to the induction of apoptosis.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Takeshima H,Kawahara Y,Hirano H,Obara S,Niiro M,Kuratsu J

doi

10.1227/01.neu.0000084165.60662.6d

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

979-83; discussion 983-4

issue

4

eissn

0148-396X

issn

1524-4040

journal_volume

53

pub_type

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