Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels.


:Previous studies showed that prolonged access to cocaine or heroin self-administration (long access, or LgA) produces an escalation in drug intake not observed with limited access to the drug (short access, or ShA). The present experiment employed in vivo microdialysis to test the role of alterations in drug pharmacokinetics and/or efficacy in increasing dopamine (DA) levels in the nucleus accumbens (NAcc) during cocaine intake escalation. In experiment 1, both ShA and LgA rats were challenged with passive intravenous administration of cocaine (0.125-1 mg/injection). Regardless of the doses tested, there was no difference between groups in the ability of cocaine to increase NAcc DA levels and no group differences in the temporal profile of dialysate cocaine levels. In experiment 2, cocaine and DA concentrations were measured during cocaine self-administration. Self-administration produced sustained increases of DA in the NAcc with LgA rats maintaining greater steady levels of DA (750% of baseline) than ShA rats (400% of baseline). The difference in the LgA versus ShA rats was not due to differences in the efficacy of cocaine to elevate DA levels, or in the rate of cocaine metabolism, but was directly related to the amount of self-administered cocaine. These findings show that changes in cocaine efficacy or pharmacokinetics do not play a critical role in cocaine intake escalation.


J Neurochem


Ahmed SH,Lin D,Koob GF,Parsons LH





Has Abstract


2003-07-01 00:00:00














  • The cysteine-rich region and the whey acidic protein domain are essential for anosmin-1 biological functions.

    abstract::The protein anosmin-1, coded by the KAL1 gene responsible for the X-linked form of Kallmann syndrome (KS), exerts its biological effects mainly through the interaction with and signal modulation of fibroblast growth factor receptor 1 (FGFR1). We have previously shown the interaction of the third fibronectin-like type ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Esteban PF,Murcia-Belmonte V,García-González D,de Castro F

    更新日期:2013-03-01 00:00:00

  • ADP-ribosylation of human myelin basic protein.

    abstract::When isolated myelin membranes were ADP-ribosylated by [32P]NAD+ either in the absence of toxin (by the membrane ADP-ribosyltransferase) or in the presence of cholera toxin, the same proteins were ADP-ribosylated in both cases and myelin basic protein (MBP) was the major radioactive product. Therefore, cholera toxin w...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Boulias C,Moscarello MA

    更新日期:1994-07-01 00:00:00

  • Potentiation by the tetraphenylboron anion of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its pyridinium metabolite.

    abstract::The 1-methyl-4-phenylpyridinium species (MPP+) is the four-electron oxidation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and is widely assumed to be the actual neurotoxic species responsible for the MPTP-induced destruction of dopaminergic neurons. MPTP is oxidized by the enzyme monoamine oxidase-B...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Heikkila RE,Hwang J,Ofori S,Geller HM,Nicklas WJ

    更新日期:1990-03-01 00:00:00

  • Regulation of neural progenitor cell development in the nervous system.

    abstract::The mammalian telencephalon, which comprises the cerebral cortex, olfactory bulb, hippocampus, basal ganglia, and amygdala, is the most complex and intricate region of the CNS. It is the seat of all higher brain functions including the storage and retrieval of memories, the integration and processing of sensory and mo...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审


    authors: Corbin JG,Gaiano N,Juliano SL,Poluch S,Stancik E,Haydar TF

    更新日期:2008-09-01 00:00:00

  • Molecular identification and functional role of voltage-gated sodium channels in rat carotid body chemoreceptor cells. Regulation of expression by chronic hypoxia in vivo.

    abstract::We have assessed the expression, molecular identification and functional role of Na+ channels (Na(v)) in carotid bodies (CB) obtained from normoxic and chronically hypoxic adult rats. Veratridine evoked release of catecholamines (CA) from an in vitro preparation of intact CBs obtained from normoxic animals, the respon...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Caceres AI,Obeso A,Gonzalez C,Rocher A

    更新日期:2007-07-01 00:00:00

  • Inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the neonatal rat hippocampus by 2-amino-3-phosphonopropionate.

    abstract::The effects of excitatory amino acid agonists and alpha-amino-omega-phosphonocarboxylic acid antagonists on phosphoinositide hydrolysis in hippocampal slices of the 7-day neonatal rat were examined. Significant stimulation of [3H]inositol monophosphate formation was observed with ibotenate, quisqualate, L-glutamate, L...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Schoepp DD,Johnson BG

    更新日期:1989-12-01 00:00:00

  • Alteration of alpha-tocopherol content in the developing and aging peripheral nervous system: persistence of high correlations with total and specific (n-6) polyunsaturated fatty acids.

    abstract::In contrast to brain, the sciatic nerve concentration of vitamin E in rats increased rapidly during the postnatal period (approximately fivefold between days 1 and 8), then decreased dramatically (about twofold between days 8 and 30), and further decreased slowly between days 30 and 60 and remained constant up to 2 ye...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Clément M,Bourre JM

    更新日期:1990-06-01 00:00:00

  • Differential protein expression in the corpus callosum (body) of human alcoholic brain.

    abstract::Neuroimage analysis in alcoholic corpus callosum (CC) suggests that microstructural abnormalities are higher in the genu followed by the body and the splenium. Molecular mechanisms underlying these dysmorphologys are still unclear. Protein expression was performed using the CC body samples [(nine controls, seven uncom...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Kashem MA,Etages HD,Kopitar-Jerala N,McGregor IS,Matsumoto I

    更新日期:2009-07-01 00:00:00

  • Internalization of mammalian fluorescent cellular prion protein and N-terminal deletion mutants in living cells.

    abstract::The cellular prion protein (PrP(c)) is a glycosylphosphatidylinositol (GPI)-anchored plasma membrane protein whose conformational altered forms (PrP(sc)) are known to cause neurodegenerative diseases in mammals. In order to investigate the intracellular traffic of mammalian PrP(c) in living cells, we have generated a ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Lee KS,Magalhães AC,Zanata SM,Brentani RR,Martins VR,Prado MA

    更新日期:2001-10-01 00:00:00

  • Protein kinase D exerts neuroprotective functions during oxidative stress via nuclear factor kappa B-independent signaling pathways.

    abstract::Members of the protein kinase D (PKD) family of serine/threonine kinases are known to exert diverse roles in neuronal stress responses. Here, we show the transient activation and nuclear translocation of endogenous PKD upon oxidative stress induced by H2 O2 treatment in primary neuronal cultures. Using pharmacological...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Liliom H,Tárnok K,Ábrahám Z,Rácz B,Hausser A,Schlett K

    更新日期:2017-09-01 00:00:00

  • Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.

    abstract::Alpha-synuclein (ASYN) is a major constituent of the typical protein aggregates observed in several neurodegenerative diseases that are collectively referred to as synucleinopathies. A causal involvement of ASYN in the initiation and progression of neurological diseases is suggested by observations indicating that sin...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审


    authors: Schildknecht S,Gerding HR,Karreman C,Drescher M,Lashuel HA,Outeiro TF,Di Monte DA,Leist M

    更新日期:2013-05-01 00:00:00

  • Subdivision of mouse brain [3H]imipramine binding based on ion dependence and serotonin sensitivity.

    abstract::The specific binding of [3H]imipramine to mouse brain membranes in an assay containing 120 mM NaCl and 5 mM KCl was similar in regional distribution and pharmacological specificity to that reported previously in rat and human brain. However, the absence of ions decreased the density of the specific binding of [3H]imip...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Severson JA,Woodward JJ,Wilcox RE

    更新日期:1986-06-01 00:00:00

  • Effect of fatty acids on [3H]ouabain binding to cerebromicrovascular (Na+ + K+)-ATPase.

    abstract::The effects of short- and long-chain fatty acids on the cerebromicrovascular (Na+ + K+)-ATPase were investigated using specific [3H]ouabain binding to the enzyme. Specific binding increased linearly with total microvessel protein (37-110 micrograms) and was time-dependent with maximum binding obtained by 10 min. Arach...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Caspers ML,Grammas P

    更新日期:1988-04-01 00:00:00

  • Structure of the mannose-rich oligosaccharide chains of concanavalin A-binding glycopeptides derived from beef brain glycoproteins.

    abstract::A neutral, mannose-rich, concanavalin A (Con A)-binding glycopeptide fraction was obtained by proteolytic digestion of defatted beef brain tissue. Hydrazinolysis followed by gel filtration of the reaction products provided three oligosaccharides. A portion of each oligosaccharide was treated by exhaustive digestion wi...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Somawardhana CW,Brunngraber EG

    更新日期:1983-08-01 00:00:00

  • Kainic acid inhibits the synaptosomal plasma membrane glutamate carrier and allows glutamate leakage from the cytoplasm but does not affect glutamate exocytosis.

    abstract::Kainate inhibits the exchange of D-aspartate into guinea-pig cerebrocortical synaptosomes. Kainate inhibits the Ca2+-independent efflux of endogenous glutamate in the presence of a trapping system for the released amino acid but potentiates a Ca2+-independent net efflux of endogenous and labelled glutamate and asparta...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Pocock JM,Murphie HM,Nicholls DG

    更新日期:1988-03-01 00:00:00

  • Formation of N-pyroglutamyl peptides from N-Glu and N-Gln precursors in Aplysia neurons.

    abstract::Matrix-assisted laser desorption/ionization with time-of-flight mass spectrometry is used to examine the formation of N-pyroglutamate (pGlu) in single, identified neurons from Aplysia. Six pGlu peptides are identified in the R3-14 and the R15 neurons that result from in vivo processing of peptides containing either Gl...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Garden RW,Moroz TP,Gleeson JM,Floyd PD,Li L,Rubakhin SS,Sweedler JV

    更新日期:1999-02-01 00:00:00

  • Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide.

    abstract::The N-type voltage-gated calcium channel (CaV2.2) is a clinically endorsed target in chronic pain treatments. As directly targeting the channel can lead to multiple adverse side effects, targeting modulators of CaV2.2 may prove better. We previously identified ST1-104, a short peptide from the collapsin response media...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Ju W,Li Q,Allette YM,Ripsch MS,White FA,Khanna R

    更新日期:2013-03-01 00:00:00

  • c-Jun N-terminal kinase regulates mGluR-dependent expression of post-synaptic FMRP target proteins.

    abstract::Fragile X syndrome (FXS) is caused by the loss of functional fragile X mental retardation protein (FMRP). Loss of FMRP results in an elevated basal protein expression profile of FMRP targeted mRNAs, a loss of local metabotropic glutamate receptor (mGluR)-regulated protein synthesis, exaggerated long-term depression an...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Schmit TL,Dowell JA,Maes ME,Wilhelm M

    更新日期:2013-12-01 00:00:00

  • Structure-activity relationships of conformationally constrained peptide analogues of loop 2 of brain-derived neurotrophic factor.

    abstract::Brain-derived neurotrophic factor (BDNF) promotes the survival of various neuronal populations and thus shows potential in the treatment of neurodegenerative disease. However, BDNF is not pharmacokinetically optimal for use as a therapeutic agent. As a step toward the development of low-molecular-weight BDNF-like drug...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: O'Leary PD,Hughes RA

    更新日期:1998-04-01 00:00:00

  • Restraint stress increases neuroinflammation independently of amyloid β levels in amyloid precursor protein/PS1 transgenic mice.

    abstract::Both hypercortisolemia and hippocampal damage are features found in patients diagnosed of Alzheimer's disease (AD) and epidemiological evidence supports a role for stress as a risk factor for AD. It is known that immobilization stress is followed by accumulation of oxidative/nitrosative mediators in brain after the re...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Perez Nievas BG,Hammerschmidt T,Kummer MP,Terwel D,Leza JC,Heneka MT

    更新日期:2011-01-01 00:00:00

  • Netrin-1-independent adenosine A2b receptor activation regulates the response of axons to netrin-1 by controlling cell surface levels of UNC5A receptors.

    abstract::Growth cone response to the bifunctional guidance cue netrin-1 is regulated by the activity of intracellular signaling intermediates such as protein kinase C-alpha (PKCalpha) and adenylyl cyclase. Among the diverse cellular events these enzymes regulate is receptor trafficking. Netrin-1, itself, may govern the activit...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: McKenna WL,Wong-Staal C,Kim GC,Macias H,Hinck L,Bartoe JL

    更新日期:2008-02-01 00:00:00

  • Receptor binding activities of biotinylated derivatives of beta-nerve growth factor.

    abstract::beta-nerve growth factor (NGF) was modified by biotinylation via carboxyl group substitution (C-bio-NGF) using biotin hydrazide and the coupling reagent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide, under reaction conditions that yielded an average of 3 biotin additions per NGF subunit. NGF was also biotinylated thr...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Rosenberg MB,Hawrot E,Breakefield XO

    更新日期:1986-02-01 00:00:00

  • Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain.

    abstract::Although considerable evidence supports a role for excitatory amino acids in the pathogenesis of ischemic neuronal injury, few in vivo studies have examined the effect of increasing durations of ischemia on the extracellular concentrations of these agents. Recently, other neurotransmitters (e.g., glycine and dopamine)...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Baker AJ,Zornow MH,Scheller MS,Yaksh TL,Skilling SR,Smullin DH,Larson AA,Kuczenski R

    更新日期:1991-10-01 00:00:00

  • Tyrosine hydroxylase is activated and phosphorylated on different sites in rat pheochromocytoma PC12 cells treated with phorbol ester and forskolin.

    abstract::Incubation of rat pheochromocytoma PC12 cells with 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), an activator of Ca2+/phospholipid-dependent protein kinase (protein kinase C), or forskolin, an activator of adenylate cyclase, is associated with increased activity and enhanced phosphorylation of tyrosine hydr...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Tachikawa E,Tank AW,Weiner DH,Mosimann WF,Yanagihara N,Weiner N

    更新日期:1987-05-01 00:00:00

  • Phosphorylation of superior cervical ganglion proteins during regeneration.

    abstract::The incorporation of radioactive phosphate into proteins of both normal and regenerating ganglia of the sympathetic nervous system of the rat is reported. The incorporation reactions were carried out in vitro by incubating homogenates of excised ganglia with [gamma-32P]ATP under various conditions. It was found that i...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Watterson JG,Good R,Moses E,Hearn MT,Austin L

    更新日期:1989-06-01 00:00:00

  • Identification of truncated C-terminal fragments of the Alzheimer's disease amyloid protein precursor derived from sequential proteolytic pathways.

    abstract::Recent evidence supports the emerging hypothesis that the amyloid-β precursor protein C-terminal fragments (APP-CTFs) and dysregulations in both their qualitative and quantitative productions may actively and directly contribute to the neuronal toxicity in early phases of Alzheimer's disease (AD). These new findings r...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Mosser S,Gerber H,Fraering PC

    更新日期:2020-08-05 00:00:00

  • The picrotoxinin binding site and its relationship to the GABA receptor complex.

    abstract::The binding characteristics of [3H] alpha-dihydropicrotoxinin to the picrotoxinin binding site were investigated in membrane preparations of adult rat forebrain and living cultures of rat cerebral cortex. The binding of [3H]alpha-dihydropicrotoxinin to rat forebrain was decreased by lysing, treating with Triton X-100,...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: White WF,Snodgrass SR,Dichter MA

    更新日期:1985-03-01 00:00:00

  • Involvement of Na+,K(+)ATPase in the mitogenic effect of insulin-like growth factor-I on cultured rat astrocytes.

    abstract::We have previously reported that insulin/insulin-like growth factor (IGF)-I induced the alpha 1 isoform of Na+,K(+)-ATPase in cultured astrocytes. In this study the effects of insulin/IGF-I on Na+,K(+)-ATPase activity and cell proliferation were examined in astrocytes cultured under the various conditions, to test the...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Matsuda T,Murata Y,Tanaka K,Hosoi R,Hayashi M,Tamada K,Takuma K,Baba A

    更新日期:1996-02-01 00:00:00

  • Cyanide-induced apoptosis and oxidative stress in differentiated PC12 cells.

    abstract::Terminally differentiated PC12 cells are a useful neuron-like model for studying programmed cell death in response to nerve growth factor (NGF) deprivation. This in vitro model was used to investigate the mechanism by which cyanide-induced histotoxic hypoxia produces neuronal degeneration. Treatment of undifferentiate...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Mills EM,Gunasekar PG,Pavlakovic G,Isom GE

    更新日期:1996-09-01 00:00:00

  • Loss of cannabinoid-stimulated guanosine 5'-O-(3-[(35)S]Thiotriphosphate) binding without receptor down-regulation in brain regions of anandamide-tolerant rats.

    abstract::The endogenous cannabinoid anandamide has been reported to produce well-defined behavioral tolerance, but studies on the possible mechanisms underlying this process are few and often contradictory. The present study was designed to survey the cellular events involved in anandamide tolerance, in terms of the effects on...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Rubino T,Viganò D,Costa B,Colleoni M,Parolaro D

    更新日期:2000-12-01 00:00:00