Abstract:
AIM:To study the efficacy and safety of tacrolimus in primary membranous nephropathy. METHOD:We describe 3 patients with primary membranous nephropathy who were either resistant to or could not tolerate steroid with or without cytotoxic agents. They were treated with tacrolimus 0.2 mg/kg/day for 6 months. The dosage of tacrolimus was adjusted to keep a whole blood tacrolimus level of 5-10 ng/ml. RESULTS:One patient had almost complete disappearance of proteinuria while the other 2 had at least 50% reduction in proteinuria. Proteinuria increased again in 2 of the patients after tacrolimus was stopped, but in neither of them proteinuria returned to the pretreatment level 6 months after tacrolimus was stopped. CONCLUSION:We conclude that tacrolimus may have a modest efficacy in the treatment of resistant membranous nephropathy.
journal_name
Clin Nephroljournal_title
Clinical nephrologyauthors
Szeto CC,Leung CB,Lai FM,Li PKdoi
10.5414/cnp59293keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
293-6issue
4eissn
0301-0430journal_volume
59pub_type
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